Septal infusions of glucose or pyruvate,but not fructose,produce avoidance deficits when co-infused with the GABA agonist muscimol

Although glucose typically enhances memory or reverses memory deficits, glucose can also produce memory deficits when co-infused with the gamma-aminobutyric acid (GABA) agonist muscimol into the medial septum (Parent & Gold, 1997; Parent, Laurey, Wilkniss, & Gold, 1997). To date the mechanisms underlying the memory-impairing interaction between GABA and glucose remain unknown. Here we investigate whether this effect is the result of hyperosmolar conditions or may involve glucose metabolism. Male Sprague-Dawley rats were given one-trial inhibitory avoidance training after receiving septal infusions of vehicle (phosphate-buffered saline, 0.5 microl), the GABA(A) agonist muscimol (3 nmol), glucose (16.5, 33, or 66 nmol), fructose (33 nmol), pyruvate (33 nmol), or a solution containing muscimol combined with glucose, fructose, or pyruvate. Retention performance was tested 48 h later. Infusions of glucose, pyruvate, fructose, or muscimol alone did not affect retention performance. However, co-infusions of all doses of glucose (16.5, 33, or 66 nmol) or the glycolytic end product pyruvate with muscimol impaired retention performance. Co-infusions of fructose with muscimol did not affect retention performance. These results suggest that the memory-impairing interaction between glucose and muscimol does not result from hyperosmolar conditions, because equiosmolar concentrations of fructose do not mimic the effects of glucose and the memory deficits do not vary as a function of glucose concentration. The finding that pyruvate mimicked the effects of glucose and impaired memory when combined with muscimol suggests that glucose metabolism may be involved in the memory-impairing interaction between glucose and GABA(A) receptors in the medial septum.     

Self-transcendent emotions and their influence on organizational effectiveness: A literature review and synthesis

Self-transcendent emotions are positive emotions that arise out of other-focused appraisals. These emotions shift attention from the self to the needs and concerns of others. Limited work, however, focuses on self-transcendent emotions and the underlying cognitive and behavioural mechanisms by which they benefit organizations. We review the disparate streams of research on self-transcendent emotions and detail the thought-action repertoires of four self-transcendent emotions (compassion, gratitude, inspiration, and awe), explaining how each contributes to effective organizational functioning. Central to achieving this aim is the broaden-and-build theory. We show how the four self-transcendent emotions broaden cognitive processes and build the necessary resources leading to specific positive organizational outcomes. We conclude our review with four themes: (a) the importance of delineating levels of analysis in self-transcendent emotion research, (b) acknowledging contextual and cross-cultural differences shaping the experience of self-transcendent emotions, (c) addressing measurement concerns, and (d) the examination of other self-transcendent emotions. In effect, we synthesize the positive psychology and organizational behaviour literature, generating a framework that prompts theoretical and practical considerations for the role of self-transcendent emotions in organizations.     

Ethically Allocating COVID-19 Drugs Via Pre-approval Access and Emergency Use Authorization

Abstract

Allocating access to unapproved COVID-19 drugs available via Pre-Approval Access pathways or Emergency Use Authorization raises unique challenges at the intersection of clinical care and research. In conditions of scarcity, prioritization approaches should minimize harm, maximize benefit, and promote fairness. To promote continued data collection, patients seeking access to unproven COVID-19 drugs should receive lower priority for allocation when they decline to participate in clinical trials, either of the requested drug or other investigational products, offering a comparable balance of risks and benefits; special attention should be paid to concerns of voluntariness and distrust. In addition, institutional treatment protocols that can contribute more robust real world data should be preferred to single patient requests for access, with priority for inclusion based on traditional clinical allocation criteria relying on available evidence. Fairness demands distribution of these protocols across a diverse range of sites, particularly those serving marginalized populations, among other protections.     

Self-control in action: implicit dispositions toward goals and away from temptations

Five studies examined whether, in self-control dilemmas, individuals develop an implicit disposition to approach goals and avoid temptations, psychologically as well as physically. Using a method developed by A. K. Solarz (1960; see also K. L. Duckworth, J. A. Bargh, M. Garcia, & S. Chaiken, 2002), the authors assessed the time for pulling and pushing a lever in response to goal- and temptation-related stimuli (e.g., studying and partying). The results show that individuals offset the influence of tempting activities by automatically avoiding these stimuli (faster pushing responses) and by approaching stimuli related to an overarching goal (faster pulling responses). These implicit self-control dispositions varied as a function of the magnitude of the self-control conflict, itself defined by how strongly individuals were attracted to temptations and held the longer term goal. These dispositions were further shown to play a role in successful self-control.     

DO ADJUSTING‐AMOUNT AND ADJUSTING‐DELAY PROCEDURES PRODUCE EQUIVALENT ESTIMATES OF SUBJECTIVE VALUE IN PIGEONS?

The current experiment examined whether adjusting-amount and adjusting-delay procedures provide equivalent measures of discounting. Pigeons' discounting on the two procedures was compared using a within-subject yoking technique in which the indifference point (number of pellets or time until reinforcement) obtained with one procedure determined the value of the corresponding variable in the yoked condition with the other procedure. Behavior on each procedure was well described by a hyperbolic discounting function. Results revealed no systematic differences in the degree of discounting as measured by the discounting rate parameter of the hyperbola in Experiment 1, which used 20-mg pellets. These results were replicated in Experiment 2 using smaller, 14-mg pellets, which potentially yield more precise measurement of indifference points on the adjusting-amount procedure. The finding that estimates of the k parameter in the hyperbolic discounting function obtained with one procedure did not differ systematically from estimates obtained from the same subjects with the other procedure represents strong support for the hypothesis that the same process underlies the discounting of delayed rewards on both adjusting-amount and adjusting-delay procedures.     

Is It Justifiable to Abandon All Search for a Logic of Discovery?

In his influential paper, ‘Why Was the Logic of Discovery Abandoned?’, Laudan contends that there has been no philosophical rationale for a logic of discovery since the emergence of consequentialism in the 19th century. It is the purpose of this paper to show that consequentialism does not involve the rejection of all types of logic of discovery. Laudan goes too far in his interpretation of the historical shift from generativism to consequentialism, and his claim that the context of pursuit belongs to neither discovery nor justification is based on narrow interpretations of the contexts of discovery and justification. As a result, Laudan draws unwarranted conclusions concerning both the early and contemporary defenders of a logic of discovery. A methodological logic of discovery—which involves self‐corrective methods of hypothesis generation that promote the long‐term goals of science and which require consequential support for justification—is a type of logic of discovery that survives the shift to consequentialism.     

Psychiatric Morbidity and Family Environment Among Female Juvenile Detainees in a Malaysian Sample

Family environmental factors have been implicated in the development of delinquency and adolescent psychiatric disorders. We examined the association between psychiatric disorders and family environmental factors among female juvenile detainees. A hundred female juvenile detainees in a Malaysian rehabilitation center (12–17 years-old) were assessed using the Mini International Neuropsychiatric Interview for Child and Adolescent and the Family Environment Scale. Majority of participants (56 %) had a psychiatric disorder, the commonest being Disruptive Behavior Disorders (40 %) and Depressive Disorders (30 %). Multivariate analysis found younger age (OR 0.52; 95 % CI 0.29, 0.94), older maternal age (OR 1.15; 95 % CI 1.03, 1.28), family history of crime (OR 7.19; 95 % CI 1.05, 49.43), family environment i.e. achievement orientation (OR 1.11; 95 % CI 1.02, 1.20) and control (OR 1.12; 95 % CI 1.03, 1.22) as significant factors for psychiatric disorder. This study demonstrated the role of age (younger adolescent and older mother), family history of crime and family environment beyond socio-economic status in psychiatric morbidity among female juvenile detainees. Future larger studies are needed to clarify familial-genetic factors that may impact strategies for family-centric mental health interventions.     

Examining the influence of anecdotal stories and the interplay of individual differences on reasoning

In two experiments, we explored whether anecdotal stories influenced how individuals reasoned when evaluating scientific news articles. We additionally considered the role of education level and thinking dispositions on reasoning. Participants evaluated eight scientific news articles that drew questionable interpretations from the evidence. Overall, anecdotal stories decreased the ability to reason scientifically even when controlling for education level and thinking dispositions. Additionally, we found that article length was related to participants' ratings of the news articles. Our study demonstrates that anecdotes can discourage scientific reasoning while also pointing to the potential influence of article length on judgements of quality.     

Yearning and Its Measurement in Complicated Grief

Persistent intense yearning for the deceased is a core clinical feature of complicated grief (CG) that distinguishes it from other mental disorders that develop following loss. The Yearning in Situations of Loss Scale (YSL) is a recently developed assessment of yearning. To assess the psychometric properties of the YSL in those with CG, we administered the YSL, Inventory of Complicated Grief, and Quick Inventory of Depression Symptomatology to 303 treatment-seeking bereaved adults with CG. Our results suggest the YSL is a reliable assessment with acceptable convergent and discriminant validity as a measure of yearning in those with CG.     

A Slippery Myth: How Learning Style Beliefs Shape Reasoning about Multimodal Instruction and Related Scientific Evidence

The learning style myth is a commonly held myth that matching instruction to a student's “learning style” will result in improved learning, while providing mismatched instruction will result in suboptimal learning. The present study used a short online reasoning exercise about the efficacy of multimodal instruction to investigate the nature of learning styles beliefs. We aimed to: understand how learning style beliefs interact with beliefs about multimodal learning; characterize the potential complexity of learning style beliefs and understand how this short exercise might influence endorsements of learning styles. Many participants who believed in the learning style myth supported the efficacy of multimodal learning, and many were willing to revise their belief in the myth after the exercise. Personal experiences and worldviews were commonly cited as reasons for maintaining beliefs in learning styles. Findings reveal the complexity of learning style beliefs, and how they interact with evidence in previously undocumented ways.