Return of Genetic Results in the Familial Dilated Cardiomyopathy Research Project

The goal of the Familial Dilated Cardiomyopathy (FDC) Research Project, initiated in 1993, has been to identify and characterize FDC genetic cause. All participating individuals have been consented for the return of genetic results, an important but challenging undertaking. Since the inception of the Project we have enrolled 606 probands, and 269 of these had 1670 family members also enrolled. Each subject was evaluated for idiopathic dilated cardiomyopathy (IDC) and pedigrees were categorized as familial or sporadic. The coding regions of 14 genes were resequenced in 311 to 324 probands in five studies. Ninety-two probands were found to carry nonsynonymous rare variants absent in controls, and with Clinical Laboratory Improvement Amendment of 1988 (CLIA) compliant protocols, relevant genetic results were returned to these probands and their consented relatives by study genetic counselors and physicians in 353 letters. In 10 of the 51 families that received results >1 year ago, at least 23 individuals underwent CLIA confirmation testing for their family’s rare variant. Return of genetic results has been successfully undertaken in the FDC Research Project. This report describes the methods utilized in the process of returning research results. We use this information as a springboard for providing guidance to other genetic research groups and proposing future directions in this arena.     

Pereboom’s Frankfurt case and derivative culpability

Pereboom has formulated a Frankfurt-style counterexample in which an agent is alleged to be responsible despite the fact that there are only non-robust alternatives present (Pereboom, Moral responsibility and alternative possibilities: essays on the importance of alternative possibilities, 2003; Phil Explor 12(2):109–118, 2009). I support Widerker’s objection to Pereboom’s Tax Evasion 2 example (Widerker, J Phil 103(4):163–187, 2006) (which rests on the worry that the agent in this example is derivatively culpable as opposed to directly responsible) against Pereboom’s recent counterarguments to this objection (Pereboom 2009). Building on work by Moya (J Phil 104:475–486, 2007; Critica 43(128):3–26, 2011) and Widerker (Widerker 2006), I argue that there is good reason to measure the robustness of alternatives in terms of comparative, rather than non-comparative likelihood of exemption, where the important factor for blame is whether the agent is “doing her reasonable best” to avoid blameworthy behaviour. I maintain that an agent only ever appears responsible when alternatives are robust in this sense. In Pereboom’s examples, both Tax Evasion 2, and his more recent version, Tax Evasion 3 (Pereboom 2009), I maintain the robustness of the alternatives, so understood, is unclear. We can clear up any ambiguity by sharpening the examples, and the result is that the agent appears responsible when the alternatives are made clearly robust, and does not appear responsible when alternatives appear clearly non-robust. The comparative nature of our judgements about blame, I maintain helps to explain the continuing appeal of the “leeway-incompatibilist” viewpoint.     

The role of input–output modality compatibility in task switching

Input–output (I–O) modality compatibility refers to the similarity of stimulus modality and modality of response-related sensory consequences. A previous study found higher switch costs in task switching in I–O modality incompatible tasks (auditory-manual and visual-vocal) than in I–O modality compatible tasks (auditory-vocal and visual-manual). However, these tasks had spatially compatible S–R mappings, which implied dimensional overlap (DO). DO may have led to automatic activation of the corresponding compatible responses in the incorrect response modality, thus increasing interference effects. The present study was aimed to examine the influence of DO on I–O modality compatibility effects. In two experiments, we found that I–O modality compatibility affects task switching even in tasks without DO, which even tended to result in further increased modality influences. This finding suggests that I–O modality mappings affect response selection by affecting between-task cross-talk not on the level of specific response codes but on the level of modality-specific processing pathways.     

Racist Events and Ethnic Identity in Low Income, African Americans

This study was designed to determine the relation between racist events and ethnic identity in a group of 100 low-income African Americans. Findings indicated that the more racist events one experienced, the more ethnic behaviors they endorsed and the more they had explored the meaning of their ethnic background. In addition, racist events were also indicative of feeling less close to individuals of other ethnic groups. Results suggest that experiencing racist events may contribute to an increased identification with one's own ethnic background and less affiliation with those of other ethnic backgrounds, with the cumulative effect of racist events over one's lifetime contributing the most to this finding.     

Temporal information processing and pitch discrimination as predictors of general intelligence.

In the present study, the relationship between performance on temporal and pitch discrimination and psychometric intelligence was investigated in a sample of 164 participants by means of an experimental dissociation paradigm. Performance on both temporal and pitch discrimination was substantially related to psychometric intelligence (r=.43 and r =.39). Regression analysis and structural equation modeling suggested that both psychophysical domains can be considered as valid predictors of psychometric intelligence. Both predictor variables contributed substantial portions of both shared and unique variance to the prediction of individual differences in psychometric intelligence. Thus, the present study yielded further evidence for a functional relationship between psychometric intelligence and temporal as well as pitch discrimination acuity. Eventually, findings are consistent with the notion that temporal discrimination - in addition to general aspects of sensory discrimination shared with pitch discrimination reflects specific intelligence-related aspects of neural information processing.     

Size matters: Attracting new immigrants to Canadian cities

Montreal, Toronto, and Vancouver have attracted most new immigrants to Canada. Small and medium-sized cities in Canada are keen to share the wealth that new immigrants represent, and federal and provincial governments support a more even distribution of settlement. As a result, the idea of attracting new immigrants to smaller locations is a pressing policy issue. This research weighs the characteristics of place that new immigrants consider on arrival. It uses findings from the Longitudinal Survey of Immigrants to Canada (Statistics Canada, 2003) to construct an index that ranks five medium-sized cities in British Columbia in terms of their potential attractiveness to new immigrants. The index created proves robust and reliable from a statistical viewpoint. The study confirms that immigrants are attracted to cities where friends and family or other immigrants live. Moreover, the increase in attractiveness of a city is primarily related to its size. The index is an indicator of the role that population and the extant number of immigrants in situ plays in determining the appeal of smaller cities. From a policy perspective, if governments wish to “spread the wealth” associated with immigration and an expanded labour force, a proactive policy stance that enumerates and communicates the appeal of less prominent communities is vital. This is an important finding, and we offer policy options that account for the relationship of population size to immigrant retention.     

The demand for contrastive explanations

Philosophical Studies - A “contrastive explanation” explains not only why some event A occurred, but why A occurred as opposed to some alternative event B. Some philosophers argue that...     

Production of non-canonical sentences in agrammatic aphasia: limits in representation or rule application?

The study reported here compares two linguistically informed hypotheses on agrammatic sentence production, the TPH [Friedmann, N., & Grodzinsky, Y. (1997). Tense and agreement in agrammatic production: Pruning the syntactic tree. Brain and Language, 56, 397-425.] and the DOP [Bastiaanse, R., & van Zonneveld, R. (2005). Sentence production with verbs of alternating transitivity in agrammatic Broca's aphasia. Journal of Neurolinguistics, 18, 59-66]. To explain impaired production of non-canonical sentences in agrammatism, the TPH basically relies on deleted or pruned clause structure positions in the left periphery, whereas the DOP appeals to limitations in the application of movement rules. Certain non-canonical sentences such as object-questions and object-relative clauses require the availability of nodes in the left periphery as well as movement to these nodes. In languages with relatively fixed word order such as English, the relevant test cases generally involve a coincidence of left periphery and movement, such that the predictions of the TPH and the DOP are identical although for different reasons. In languages with relatively free word order such as German, on the other hand, it is possible to devise specific tests of the different predictions due to the availability of scrambling. Scrambled object sentences, for example, do not involve the left periphery but do require application of movement in a domain below the left periphery. A study was conducted with German agrammatic subjects which elicited canonical sentences without object movement and non-canonical scrambled sentences with object movement. The results show that agrammatic speakers have a particular problem with the production of scrambled sentences. Further evidence reported in the study from spontaneous speech, elicitation of object relatives, questions and passives and with different agrammatic subjects confirms that non-canonical sentences are generally harder to produce for agrammatics. These findings provide evidence in favor of the DOP and it will be argued that a cross-modal explanation of agrammatic deficits is possible if two factors--movement and canonicity--are taken into consideration.     

Forgiveness and psychological adjustment following interpersonal transgressions: A longitudinal analysis

Forgiveness is often assumed to be adaptive for psychological adjustment following interpersonal transgressions. Three hundred and forty seven individuals who had experienced a recent interpersonal transgression were surveyed on four occasions over the course of six weeks. Forgiveness was assessed with scales measuring interpersonal avoidance and revenge motivation and psychological adjustment was assessed with scales measuring depression and rumination. Latent growth curve analyses showed that intraindividual changes in forgiveness were positively correlated with changes in adjustment. Latent difference score analyses indicated that adjustment predicted subsequent change in forgiveness, but that forgiveness did not predict subsequent change in adjustment. The results suggest that adjustment facilitates forgiveness, but not that forgiveness facilitates adjustment.