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神经肽Y是一个多肽,广泛分布于周围和中枢神经系统,以下丘脑的浓度为高,参与机体神经内分泌、情绪、行为等的调节。 为探讨慢性应激诱导的抑郁模型小鼠脑内神经肽Y (NPY)的表达,以及抗抑郁药的作用机理,采用慢性应激与孤养方法,建立抑郁小鼠模型。用旷场行为 (Open-Field)法,观察模型组与正常对照组行为学改变方面的差异。将36 只抑郁模型小鼠随机分成盐酸氟西汀组、盐酸阿米替林组、生理盐水治疗组,并与12 只正常对照组比较。用半定量逆转录-聚合酶联反应(RT-PCR) 法、细胞酶联免疫法及蛋白免疫印迹(Western-blot) 法、免疫组织化学法,比较四组小鼠下丘脑NPY 的表达。结果表明:(1)与正常组比较,抑郁模型组小鼠活动总路程与活动次数减少(p< 0.01),体重增速下降(p< 0.05)。(2)与正常组比较,抑郁模型组小鼠下丘脑NPY 的mRNA 表达下降(p< 0.01);经盐酸氟西汀、盐酸阿米替林治疗后,下丘脑NPY 的mRNA 及蛋白表达增高,与生理盐水组比较差异显著(p< 0.01)。(3) 与正常组比较,生理盐水治疗组胞膜和胞质呈棕黄色染色,显示出明显的免疫组化阳性反应;经盐酸氟西汀、盐酸阿米替林治疗后,胞膜和胞质的着色与背景色接近,免疫组化呈弱阳性、阴性反应。提示抑郁模型组小鼠脑内NPY 表达水平有显著下降,使用抗抑郁药有利于提高脑内NPY 的mRNA 及蛋白表达,可能是此类药物产生抗抑郁效应的机制之一。 相似文献
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Fidgeting was defined as engaging in manipulations of one's own body parts or other objects, such actions being peripheral or nonessential to central ongoing events or tasks Two studies employed preliminary fidgeting questionnaires of 70 and 106 items, respectively, tapping a wide range of habitual behaviors Item selection and factor analyses led to the development of a final, 40-item, individual difference measure of fidgeting tendency which is balanced for response bias and has an alpha reliability coefficient of 89 Convergent and construct validity were supported by positive correlations between the fidgeting tendency measure and measures of tendencies to engage in extraneous activities (consuming alcoholic drinks, cigarette smoking, eating, daydreaming, restlessness, insomnia) while preoccupied with certain situations and tasks These findings implied that fidgeting is an activity overflow and that it is more probable when the organism's physical activity is constrained by the central or focal act Fidgeting tendency also correlated positively with binge eating and with physical activity In two additional studies, questionnaire fidgeting tendency scores correlated positively with direct observations of fidgeting by subjects and with peer predictions Personality correlates of fidgeting tendency were well defined More fidgety persons were more unpleasant and more arousable (i e, more anxious or hostile) Fidgeting tendency did not correlate significantly with subject sex or with arousal-seeking tendency 相似文献
126.
Linoy Schwartz Michal Cohen Shan Xu Jia Liu Galit Yovel 《British journal of psychology (London, England : 1953)》2023,114(Z1):213-229
Faces are visual stimuli that convey rich social information. Previous experiments found better recognition for faces that were evaluated based on their social traits than on their perceptual features during encoding. Here, we ask whether this social-encoding benefit in face recognition is also found for categories of faces that we have no previous social experience with, such as other-race faces. To answer this question, we first explored whether social and perceptual evaluations for other-race faces are consistent and valid. We then asked whether social evaluations during encoding improve recognition for other-race faces. Results show that social and perceptual evaluations of own- and other-race faces were valid. We also found high agreement in social and perceptual evaluations across individuals from different races. This indicates that evaluations of other-race faces are not random but meaningful. Furthermore, we found that social evaluations facilitated face recognition regardless of race, demonstrating a social-encoding benefit for both own- and other-race faces. Our findings highlight the role of social information in face recognition and show how it can be used to improve recognition of categories of faces that are hard to recognize due to lack of experience with them. 相似文献
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The study aims to help characterize the sort of structures about which people can acquire unconscious knowledge. It is already well established that people can implicitly learn n-grams (chunks) and also repetition patterns. We explore the acquisition of unconscious structural knowledge of symmetry. Chinese Tang poetry uses a specific sort of mirror symmetry, an inversion rule with respect to the tones of characters in successive lines of verse. We show, using artificial poetry to control both n-gram structure and repetition patterns, that people can implicitly learn to discriminate inversions from non-inversions, presenting a challenge to existing models of implicit learning. 相似文献
128.
Ping-Feng Xu Laixu Shang Qian-Zhen Zheng Na Shan Man-Lai Tang 《The British journal of mathematical and statistical psychology》2022,75(2):363-394
The aim of latent variable selection in multidimensional item response theory (MIRT) models is to identify latent traits probed by test items of a multidimensional test. In this paper the expectation model selection (EMS) algorithm proposed by Jiang et al. (2015) is applied to minimize the Bayesian information criterion (BIC) for latent variable selection in MIRT models with a known number of latent traits. Under mild assumptions, we prove the numerical convergence of the EMS algorithm for model selection by minimizing the BIC of observed data in the presence of missing data. For the identification of MIRT models, we assume that the variances of all latent traits are unity and each latent trait has an item that is only related to it. Under this identifiability assumption, the convergence of the EMS algorithm for latent variable selection in the multidimensional two-parameter logistic (M2PL) models can be verified. We give an efficient implementation of the EMS for the M2PL models. Simulation studies show that the EMS outperforms the EM-based L1 regularization in terms of correctly selected latent variables and computation time. The EMS algorithm is applied to a real data set related to the Eysenck Personality Questionnaire. 相似文献
129.
基于资源保存理论和不确定管理理论, 采用日记研究法收集81个样本10个工作日的数据, 从静态和动态两个视角, 通过明晰挑战性工作要求的不同属性(每日水平、平均水平、日间变动、波动变化), 全面检验了挑战性工作要求对工作-家庭增益的影响。研究结果表明:(1)在静态模型中, 挑战性工作要求通过工作专注度(增益路径)和放松(损耗路径)作用于工作-家庭增益, 且在个体间的平均水平模型中, 放松的中介作用更为显著; (2)在动态模型中, 挑战性工作要求的日间变动和波动变化, 均通过减少员工工作专注度和放松, 进而降低工作-家庭增益。最后, 本研究讨论了管理者应重视挑战性工作要求的双刃剑作用等实践启示。 相似文献
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为探讨儿童期虐待对公正世界信念的作用及心理机制,本研究采用问卷法对929名大学生进行了调查,并采用潜变量模型对数据进行了分析。结果发现:(1)儿童期虐待显著负向预测大学生公正世界信念;(2)控制感在儿童期虐待与公正世界信念之间起完全中介作用;(3)家庭社会经济地位调节了儿童期虐待与控制感的关系,高家庭社会经济地位放大了儿童期虐待与控制感间的负相关。研究结果表明,可以通过预防儿童虐待和增强控制感等干预措施来提升公正世界信念,并且需要对高社会经济地位家庭的儿童虐待加大关注。 相似文献