药物成瘾诱导相关大脑核团功能和行为改变的DNA甲基化机制

药物成瘾会导致相关神经环路的结构和功能长期改变.大量新的研究证据表明,在DNA序列不变的情况下,药物成瘾可通过影响不同亚型DNA甲基转移酶(DNMTs)的表达,使脑内多个相关核团发生DNA甲基化以及基因表达的改变,进而导致神经元功能的可塑性变化.因此,DNA甲基化被视作导致成瘾行为长期存在的可能机制之一.结合近几年来的重要发现,本文将重点讨论相关脑区的DNA甲基化在成瘾行为发生发展过程中的作用,以及成瘾药物影响DNA甲基化水平的可能机制,并试图提出可深入的研究展望.     

反馈干预对学习判断的影响

将反馈干预作为外部线索引入元记忆研究,采用重复学习任务,在第一轮次学习-测验之后插入反馈干预,用两个实验分别考查任务反馈和能力反馈两种形式下的反馈效价对第二轮次即时学习判断的影响.结果表明：①在学习过程中,学习者会进行自我监测;②在任务反馈形式下,反馈信息与自我监测信息冲突,导致反馈干预对元认知监测和认知过程没有影响;③在能力反馈形式下,反馈信息与自我监测信息的冲突消失,结果消极反馈影响了元认知监测.由此得出结论：只有在不与自我监测信息冲突的情况下,反馈干预才对学习判断产生影响.此外,在有反馈干预的情况下,两个实验中都出现了显著的练习伴随低估效应.     

Inconsistent Condom Use and History of Trauma Among Vietnamese Female Sex Workers in a Chinese Border Region

Previous studies have indicated a potential association between trauma, such as physical violence, emotional violence and sexual violence, and high-risk sexual behavior. Female sex workers (FSWs) were interviewed to elicit history of traumatic events and sexual behaviors. Among 187 participants, 79 (42.2 %) inconsistently used condoms with clients in the past 30 days. Experiencing community violence (OR: 0.4; 95 % CI: 0.2, 0.8) was found to be significantly protective for inconsistent condom use. In this study, experiencing community violence was found to be protective for inconsistent condom use among FSWs, but none of the other trauma subgroups had significant associations with inconsistent condom use. Reasons for unprotected sex among FSW may be more related to economic or other contextual factors.     

Configuration of Parent-Reported and Adolescent-Perceived Career-Related Parenting Practice and Adolescents’ Career Development: A Person-Centered,Longitudinal Analysis of Chinese Parent–Adolescent Dyads

Journal of Child and Family Studies - Adolescents’ career development is associated with various contextual factors, among which career-related parenting practice is particularly important....     

将国学思想切入于我国高等医学人文教育

基于时代的发展和医学的人文回归,提出将国学思想切入于我国的高等医学人文教育,并从可为人类走出当前的某些危机、传承民族文化、提升学生道德素质及践行性角度探讨其必要性;从有助于医者职业道德的养成、科研灵感的激发和人文意识的培养探讨其应然性.     

石河子地区老年人骨质疏松性骨折影响因素调查分析

分析石河子地区骨质疏松性骨折老年人的影响因素。采用现场调查的方法,对2010年10月～2011年7月在石河子大学医学院第一附属医院和石河子市人民医院住院的60岁及以上400名骨质疏松性骨折患者进行一对一问卷调查。单因素分析,性别、年龄、父亲髋部骨折史、母亲髋部骨折史、当前是否吸烟、糖尿病史、高血压病史、类风湿性关节炎病史、既往骨折史、是否每日饮用浓茶、是否进行体育锻炼是影响本地区骨质疏松性骨折的因素。多元线性逐步回归分析,性别、父亲髋部骨折史、母亲髋部骨折史、当前是否吸烟、类风湿性关节炎病史是影响本地区骨质疏松性骨折的主要因素。影响石河子地区骨质疏松性骨折的因素是多方面的,其影响因素可为干预本地区未骨折的社区老年高危人群提供科学参考依据。     

自谦的研究综述

对自谦的思考由来已久,但是,直到二十一世纪初,人们才试图借助科学手段对自谦进行系统的研究。在心理学界,自谦仍是一个新的研究领域。自谦涉及谦礼、谦敬、谦卑、谦忍,与谦虚、谦逊密切相关。文章通过文献资料的搜集,从自谦的界定、自谦的测量、自谦的相关因素、自谦的研究取向等四个方面进行了综述。     

The five-factor model of personality traits and organizational citizenship behaviors: a meta-analysis

Using meta-analytic tests based on 87 statistically independent samples, we investigated the relationships between the five-factor model (FFM) of personality traits and organizational citizenship behaviors in both the aggregate and specific forms, including individual-directed, organization-directed, and change-oriented citizenship. We found that Emotional Stability, Extraversion, and Openness/Intellect have incremental validity for citizenship over and above Conscientiousness and Agreeableness, 2 well-established FFM predictors of citizenship. In addition, FFM personality traits predict citizenship over and above job satisfaction. Finally, we compared the effect sizes obtained in the current meta-analysis with the comparable effect sizes predicting task performance from previous meta-analyses. As a result, we found that Conscientiousness, Emotional Stability, and Extraversion have similar magnitudes of relationships with citizenship and task performance, whereas Openness and Agreeableness have stronger relationships with citizenship than with task performance. This lends some support to the idea that personality traits are (slightly) more important determinants of citizenship than of task performance. We conclude with proposed directions for future research on the relationships between FFM personality traits and specific forms of citizenship, based on the current findings.     

HBV相关肝细胞癌综合治疗中抗病毒的作用

分析抗病毒治疗在乙型肝炎病毒相关肝细胞癌的综合治疗中所起的作用.随着肝细胞癌治疗模式的转变,目前认为抗HBV治疗是HCC综合治疗的重要组成部分,应针对患者进行个体化、优化的多学科综合治疗,选择合适的高效、低耐药、低副作用的抗病毒药物,才能达到提高患者生活质量和延长生存时间的目的.     

纤维乳管镜临床应用中的问题与争议

纤维乳管镜主要应用于乳头溢液的诊断,提高了诊断的准确率,减小了手术切除范围,并修改了部分乳腺疾病的手术指征.但由于乳腺导管系统解剖的复杂性以及乳管镜本身的限制,乳管镜在乳腺导管内病变的切除、导管炎症治疗、乳腺癌筛查、保乳手术中辅助判定切缘等临床应用方面,尚存在诸多的问题与争议.