SLV330, a cannabinoid CB1 receptor antagonist,ameliorates deficits in the T-maze,object recognition and Social Recognition Tasks in rodents

Cannabinoid CB₁ receptor (CB₁R) signaling has been suggested to play an important role in the regulation of memory and cognition. In the present study, our aim was to investigate whether the CB₁R antagonist SLV330 (doses ranging from 0.3 to 10 mg/kg, given orally, p.o.) could ameliorate impairments in distinct aspects of cognition using different disruption models in both mice and rats. Effects of SLV330 were tested on working memory deficits in the T-maze Continuous Alternation Task (T-CAT) in mice; episodic memory deficits in the Object Recognition Task (ORT) and Social Recognition Task (SRT) in rats. The acetylcholinesterase inhibitor (AChEI) donepezil (Aricept®, approved for symptomatic treatment of Alzheimer’s disease) and nicotine were used as reference compounds.SLV330 markedly improved aging and scopolamine-induced memory deficits in the T-CAT in mice with a lowest effective dose (LED) of 1 mg/kg p.o., while reversing the cognitive dysfunction induced by the N-methyl-d-aspartate (NMDA) antagonist dizocilpine (MK-801) only at the middle dose of 3 mg/kg. In the ORT, we have found that combined administration of subthreshold doses of SLV330 (1 mg/kg, p.o.) and the AChEI donepezil (0.1 mg/kg, p.o.), that had no discernable effects on performance when given alone, enhanced memory performance in Wistar rats with deficits induced by the muscarinic antagonist scopolamine, suggestive of additive synergistic effects of SLV330 and donepezil on cognitive impairment. Finally, SLV330 was found to have cognition enhancing properties in a time delay paradigm in the SRT at a LED dose of 3 mg/kg (p.o.).In conclusion, the CB₁R antagonist SLV330 was found to clearly improve memory in several preclinical models for cognitive impairment.     

Face à la désorganisation somatique,animer la psyché

The author's purpose is to reflect about the function of the psychologist taking care of teenagers affected by somatic diseases, following the example of a therapy of a sixteen years old patient born with physical malformations and sexual ambiguity, suddenly suffering of severe somatic troubles, among them an insulin-dependent diabetes. The therapist may play a maternal function, as suggested by P. Marty. The idea is to give to the patient an alive, anaclitic and counter-exciting presence and a boundary context in order to make up for narcissistic deficiencies and to reach authentic movements. This article relates the way between the psychosomatic disorder and the new balance gradually reached. Trust and affective security are the preliminary conditions of autonomy.     

System of Care Development in Children’s Mental Health: Lessons Learned from a Process Evaluation

Despite ongoing public calls for reform, the mental health needs of many children with psychological, emotional and behavioral disorders remain unmet. In response, providers continue to seek effective alternatives to institutional treatment by implementing comprehensive systems of care. The Children’s Enhancement Project (CEP) is a collaborative effort to provide holistic, community-based mental health services for children with an individualized, flexible, family-driven approach. We conducted a process evaluation of CEP’s early stage development and implementation utilizing both qualitative stakeholder interviews and quantitative survey components. The current article describes that evaluation and highlights the challenges and potential solutions encountered in developing a system of care. The lessons learned regarding system of care development, including the importance of a shared vision, establishing programmatic guidelines, achieving collaboration, and addressing sustainability concerns, are discussed.     

Spirituality in Occupational Therapy: Do We Practice What We Teach?

This mixed-method study examined the responses of 97 occupational therapists on the subject of spirituality in occupational therapy practice. The inclusion of spirituality into the Occupational Therapy Practice Framework (2008) implies that clinicians address spirituality as a component of client-centered practice. This research revealed a gap between education, theory, and practice as evidenced in the quantitative and qualitative data. Although occupational therapy is intended to be holistic, therapists require a more complete understanding of what spirituality is and what the role of the occupational therapist is when addressing spirituality in evaluation or treatment. The discussion of this research provides information for future occupational therapy educators and educational programs as they seek to incorporate the construct of spirituality into curricula.     

Pilgrims sailing the Titanic: Plausibility effects on memory for misinformation

People rely on information they read even when it is inaccurate (Marsh, Meade, & Roediger, Journal of Memory and Language 49:519–536, 2003), but how ubiquitous is this phenomenon? In two experiments, we investigated whether this tendency to encode and rely on inaccuracies from text might be influenced by the plausibility of misinformation. In Experiment 1, we presented stories containing inaccurate plausible statements (e.g., “The Pilgrims’ ship was the Godspeed”), inaccurate implausible statements (e.g., . . . the Titanic), or accurate statements (e.g., . . . the Mayflower). On a subsequent test of general knowledge, participants relied significantly less on implausible than on plausible inaccuracies from the texts but continued to rely on accurate information. In Experiment 2, we replicated these results with the addition of a think-aloud procedure to elicit information about readers’ noticing and evaluative processes for plausible and implausible misinformation. Participants indicated more skepticism and less acceptance of implausible than of plausible inaccuracies. In contrast, they often failed to notice, completely ignored, and at times even explicitly accepted the misinformation provided by plausible lures. These results offer insight into the conditions under which reliance on inaccurate information occurs and suggest potential mechanisms that may underlie reported misinformation effects.     

Assessment of Needs in Residential Care: Perspectives of Youth and Professionals

The evaluation and identification of needs profiles for youth in residential care, through qualitative and quantitative methodologies involving different stakeholders, are still relatively uncommon, even though they are essential in developing specific and effective services. This article will present two studies, one with youth and another with professionals. To assess needs from the standpoint of youth, four focus groups were held with youth in residential care (n = 21). To identify needs profiles of youth from the standpoint of professionals, 47 professionals evaluated a sample of youth in residential care (n = 110) using the RCYNA questionnaire. The results of the study with youth point to needs in three main areas: living situation, social and family relationships, and education. The results of the study with professionals reveal three needs profiles with distinct risk levels: low risk, without emerging needs; intermediate risk, with needs in terms of the economic and living situation; and high risk, with needs in terms of relationships, behavioural, psychological and emotional skills, and education and employment.     

Psychometric Properties of the Alabama Parenting Questionnaire-Preschool Revision (APQ-Pr) in 3 Year-Old Spanish Preschoolers

Parenting practices should be assessed and taken into account at an early age, since it is well documented that they are strongly related to children’s development. This study provides data on the psychometric properties of a Spanish version of the Alabama Parenting Questionnaire for Preschool children (APQ-Pr). A community sample of 622 (310 boys and 312 girls) 3 year-old children and their parents, participated in the study. Data were obtained from parents’ reports and correspond to a semi-structured diagnostic interview and self-report questionnaires evaluating parenting and children’s psychological states. Confirmatory factor analysis supported a three-factor solution: positive parenting, inconsistent parenting and punitive parenting. These scales scores showed moderate to good internal consistence (omega values ranged from .54 to .86). Inconsistent parenting scores achieved the strongest associations with external measures of psychopathology, especially for externalizing and conduct problems, as well as for functional impairment, the poorest associations being for the positive parenting scores. Results support the validity of the Spanish APQ-Pr, which is potentially a useful measure for the study of parenting practices regarding preschool children and their relation to conduct problems.     

Understanding children's emotional processes and behavioral strategies in the context of marital conflict

Marital conflict is a distressing context in which children must regulate their emotion and behavior; however, the associations between the multidimensionality of conflict and children’s regulatory processes need to be examined. The current study examined differences in children’s (N = 207, mean age = 8.02 years) emotions (mad, sad, scared, and happy) and behavioral strategies to regulate conflict exposure during resolved, unresolved, escalating, and child-rearing marital conflict vignettes. Children’s cortisol levels were assessed in relation to child-rearing and resolved conflict vignettes. Anger and sadness were associated with escalating and child-rearing conflicts, fearfulness was related to escalating and unresolved conflicts, and happiness was associated with resolution. Anger was associated with children’s strategies to stop conflict, whereas sadness was associated with monitoring and avoidant strategies. Cortisol recovery moderated the link between fearfulness and behavioral regulation. These results highlight the importance of children’s emotions and regulatory processes in understanding the impact of marital conflict.