L’accès aux médicaments : quelles contributions des règles sur les brevets de l’Accord de partenariat transpacifique global et progressiste ?

Enhanced protection for patents in free trade agreements would undermine access to medicines and show difficulties for developing countries with respect to public health issue. In the context of the Comprehensive and Progressive Trans-Pacific Partnership Agreement, however, after the withdrawal of the United States, the legal regime applicable to patents seems less rigid and, therefore, more favorable to access to medicines. This results, on the one hand, from certain flexibilities contained in this agreement itself; and on the other hand, the suspension of some material and procedural obligations. This article aims to analyze these two sides to justify the contribution of this agreement to ensure access to medicines.     

Applying Occam’s razor in modeling cognition: A Bayesian approach

In mathematical modeling of cognition, it is important to have well-justified criteria for choosing among differing explanations (i.e., models) of observed data. This paper introduces a Bayesian model selection approach that formalizes Occam’s razor, choosing the simplest model that describes the data well. The choice of a model is carried out by taking into account not only the traditional model selection criteria (i.e., a model’s fit to the data and the number of parameters) but also the extension of the parameter space, and, most importantly, the functional form of the model (i.e., the way in which the parameters are combined in the model’s equation). An advantage of the approach is that it can be applied to the comparison of non-nested models as well as nested ones. Application examples are presented and implications of the results for evaluating models of cognition are discussed.     

Relationship between age and aspects of depression: consistency and reliability across two longitudinal studies

In this study, the authors examined cross-sectional and longitudinal age and gender differences in each of the Center for Epidemiological Studies Depression Scale's 4 subscales of depressive symptomatology. Two independent studies (Sample 1 = 2,076; Sample 2 = 943) were used for purposes of establishing stability of findings. Results indicate a reasonable degree of stability among adults under 70 years of age. However, there were significant age-related increases in somatic symptoms and lack of well-being after approximately 70 years of age, whereas symptoms related to depressed affect and interpersonal problems remained stable. Notably, depressive affect symptoms remained stable given significant age-related somatic changes. The addition of comorbid physical illness to the analysis did not reduce the association between age and depressive symptoms, indicating that part of the association was not substantially accounted for by physical health.     

An ecological analysis of the effects of deviant peer clustering on sexual promiscuity, problem behavior, and childbearing from early adolescence to adulthood: an enhancement of the life history framework

The authors propose that peer relationships should be included in a life history perspective on adolescent problem behavior. Longitudinal analyses were used to examine deviant peer clustering as the mediating link between attenuated family ties, peer marginalization, and social disadvantage in early adolescence and sexual promiscuity in middle adolescence and childbearing by early adulthood. Specifically, 998 youths, along with their families, were assessed at age 11 years and periodically through age 24 years. Structural equation modeling revealed that the peer-enhanced life history model provided a good fit to the longitudinal data, with deviant peer clustering strongly predicting adolescent sexual promiscuity and other correlated problem behaviors. Sexual promiscuity, as expected, also strongly predicted the number of children by ages 22-24 years. Consistent with a life history perspective, family social disadvantage directly predicted deviant peer clustering and number of children in early adulthood, controlling for all other variables in the model. These data suggest that deviant peer clustering is a core dimension of a fast life history strategy, with strong links to sexual activity and childbearing. The implications of these findings are discussed with respect to the need to integrate an evolutionary-based model of self-organized peer groups in developmental and intervention science.     

The Blues of Adolescent Romance: Observed Affective Interactions in Adolescent Romantic Relationships Associated with Depressive Symptoms

We examined the associations between observed expressions of positive and negative emotions during conflict discussions and depressive symptoms during a 2-year period in a sample of 160 adolescents in 80 romantic relationships (M age?=?15.48, SD?=?1.16). Conflict discussions were coded using the 10-code Specific Affect Coding System. Depressive symptoms were assessed at the time of the observed conflict discussions (Time 1) and 2 years later (Time 2). Data were analyzed using actor–partner interdependence models. Girls’ expression of both positive and negative emotions at T1 was related to their own depressive symptoms at T2 (actor effect). Boys’ positive emotions and negative emotions (actor effect) and girls’ negative emotions (partner effect) were related to boys’ depressive symptoms at T2. Contrary to expectation, relationship break-up and relationship satisfaction were unrelated to changes in depressive symptoms or expression of negative or positive emotion during conflict discussion. These findings underscore the unique quality of adolescent romantic relationships and suggest new directions in the study of the link between mental health and romantic involvement in adolescence.     

Classroom Peer Relationships and Behavioral Engagement in Elementary School: The Role of Social Network Equity

Applying social capital and systems theories of social processes, we examine the role of the classroom peer context in the behavioral engagement of low-income students (N = 80) in urban elementary school classrooms (N = 22). Systematic child observations were conducted to assess behavioral engagement among second to fifth graders in the fall and spring of the same school year. Classroom observations, teacher and child questionnaires, and social network data were collected in the fall. Confirming prior research, results from multilevel models indicate that students with more behavioral difficulties or less academic motivation in the fall were less behaviorally engaged in the spring. Extending prior research, classrooms with more equitably distributed and interconnected social ties—social network equity—had more behaviorally engaged students in the spring, especially in classrooms with higher levels of observed organization (i.e., effective management of behavior, time, and attention). Moreover, social network equity attenuated the negative relation between student behavioral difficulties and behavioral engagement, suggesting that students with behavioral difficulties were less disengaged in classrooms with more equitably distributed and interconnected social ties. Findings illuminate the need to consider classroom peer contexts in future research and intervention focused on the behavioral engagement of students in urban elementary schools.     

Personality Traits and Political Participation: Evidence from South Korea

Using a nationally representative survey fielded in 2009, we analyze the relationships between personality traits and various modes of political participation in South Korea. We find statistically significant relationships between personality (measured by the Five‐Factor Model) and several nonelectoral modes of participation. Openness correlates positively with protest participation, rally attendance, financial contributions to political causes, news media contacts, and political activities via the Internet. Agreeableness correlates negatively with these five participation modes as well as petition signing. Conscientiousness is positively associated with individual political acts (e.g., contacting news media and elected officials and donation), while it is negatively associated with collective actions such as participation in rally. However, we do not find any significant relationship between personality and voter turnout. Reflecting an unusually conflictual political climate of South Korea in 2008, we discuss these findings' implications focusing on the personality‐situation interactions.     

When a good fit can be bad

How should we select among computational models of cognition? Although it is commonplace to measure how well each model fits the data, this is insufficient. Good fits can be misleading because they can result from properties of the model that have nothing to do with it being a close approximation to the cognitive process of interest (e.g. overfitting). Selection methods are introduced that factor in these properties when measuring fit. Their success in outperforming standard goodness-of-fit measures stems from a focus on measuring the generalizability of a model's data-fitting abilities, which should be the goal of model selection.     

Assessment and Diagnosis of Autism Spectrum Disorder in Hanoi,Vietnam

For individuals with autism spectrum disorder (ASD), early and accurate diagnosis enables early intervention, which leads to improved quality of life. The diagnostic label of ASD has only been recognized in Vietnam since 2000 and the number of children who have been diagnosed has increased dramatically. However, there is limited understanding about the condition. This article aims to describe the current assessment and diagnostic practices in Hanoi, Vietnam, a low resource setting. Data for this article came from in-depth interviews with parents of children with ASD and service providers, and observation at health clinics and early intervention centers that provide ASD assessment during field work from July 2011 to May 2012. This study reveals that although there is some improvement in assessment services, parents still face a number of challenges in accessing quality assessment and diagnosis of ASD in Vietnam. These include rushed and perfunctory assessment; a lack of clinical guidelines for assessment; limited communication among health professionals in assessment teams, and between professionals and parents of children with ASD. Public awareness-raising of the signs of autism, capacity building for professionals, development of practical and contextual appropriate assessment protocols are needed to enhance the accessibility and quality of assessment services.