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81.
Jonathan E. Peelle John Powers Philip A. Cook Edward E. Smith Murray Grossman 《Cognitive, affective & behavioral neuroscience》2014,14(1):37-48
We hypothesized that semantic memory for object concepts involves both representations of visual feature knowledge in modality-specific association cortex and heteromodal regions that are important for integrating and organizing this semantic knowledge so that it can be used in a flexible, contextually appropriate manner. We examined this hypothesis in an fMRI study of mild Alzheimer’s disease (AD). Participants were presented with pairs of printed words and asked whether the words matched on a given visual–perceptual feature (e.g., guitar, violin: SHAPE). The stimuli probed natural kinds and manufactured objects, and the judgments involved shape or color. We found activation of bilateral ventral temporal cortex and left dorsolateral prefrontal cortex during semantic judgments, with AD patients showing less activation of these regions than healthy seniors. Moreover, AD patients showed less ventral temporal activation than did healthy seniors for manufactured objects, but not for natural kinds. We also used diffusion-weighted MRI of white matter to examine fractional anisotropy (FA). Patients with AD showed significantly reduced FA in the superior longitudinal fasciculus and inferior frontal-occipital fasciculus, which carry projections linking temporal and frontal regions of this semantic network. Our results are consistent with the hypothesis that semantic memory is supported in part by a large-scale neural network involving modality-specific association cortex, heteromodal association cortex, and projections between these regions. The semantic deficit in AD thus arises from gray matter disease that affects the representation of feature knowledge and processing its content, as well as white matter disease that interrupts the integrated functioning of this large-scale network. 相似文献
82.
To increase our understanding of relationships between well-being and social/physical functioning and self-management abilities (SMAs) among chronically ill patients. The cross-sectional questionnaire-based study included 1,254 patients with cardiovascular diseases, 725 with chronic obstructive pulmonary disease, and 253 with diabetes (total, 2232/4200; 53 % response rate). Social and physical functioning correlated significantly with SMAs and well-being (all p?≤?0.001). After controlling for background characteristics, multiple regression showed that social and physical functioning were still related to SMAs (β?=?0.32–0.12; both p?≤?0.001) and well-being (β?=?0.39–0.14; both p?≤?0.001). The strengths of relationships between well-being and social (β?=?0.39 vs. 0.20) and physical (β?=?0.14 vs. 0.07) functioning declined significantly (both p?≤?0.001) when the SMA mediator was included in the equation. SMAs of chronically ill are related to their social and physical functioning. We found indications that chronically ill patients reporting lower levels of social and physical functioning are worse self-managers than are those with higher levels of functioning. Furthermore, SMAs may mediate the relationships between social and physical functioning and well-being. Self-management interventions aiming to enhance SMAs more broadly than traditional interventions aiming only to prevent functional decline are expected to improve SMAs and enhance well-being among chronically ill patients. 相似文献
83.
Claudia Marino C. M. Hirst C. Murray A. Vieno Marcantonio M. Spada 《Journal of Happiness Studies》2018,19(7):2009-2022
Recent research on Problematic Internet Use and Problematic Facebook Use (PIU and PFU) has focused on the idea that people who engage in PIU or PFU are more likely to present with mental health problems. The goal of the present study was to examine the contribution of positive mental health (PMH) to PIU and PFU among adolescents and young adults. A total of 1927 Italian adolescents and young adults participated in the study. Structural equation modeling showed that PMH is negatively linked to both PIU and PFU, indicating that PMH may be an important antecedent for both PIU and PFU among adolescents and young adults. In conclusion, dimensions of PMH may be taken into account by researchers and educational practitioners in preventing both PIU and PFU. 相似文献
84.
85.
Jennifer L. Murray 《Deviant behavior》2015,36(7):581-588
This article examines the role that suicidal–homicidal ideation plays in influencing mass killers and draws on the author’s concept of transcendent fantasy theory. Although numerous researchers touch on the fact that 50% of mass killers commit suicide, few have traced and compared the suicidal person’s fantasy process with that of the suicidal–homicidal killer’s fantasy process. Suicidal individuals tend to be intropunitive. They internalize the blame for real or imagined failures, and they seek to escape from such failures, or to inflict punishment on him- or herself for the same reasons. Mass killers externalize the blame for their real or imagined losses. Due to their mordant bitterness toward self and others, these suicidal–homicidal individuals often fantasize not only about escaping, but transcending their feelings of inadequacy, self-doubt, and worthlessness by having society see them as powerful, clever, and superior for pulling off a massacre and making (in their view) oppressive people pay. 相似文献
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87.
When symptom is symbol: some comments on Rosemary Gordon's, ‘Masochism: the shadow side of the archetypal need to venerate and worship’ 下载免费PDF全文
Murray Stein 《The Journal of analytical psychology》2015,60(4):507-519
This paper is a commentary on Rosemary Gordon's paper, ‘Masochism: the shadow side of the archetypal need to venerate and worship’, with a suggestion for an alternative interpretation of masochism as a part of a sado‐masochistic couple. Gordon postulates an archetypal need to venerate and worship that can be hidden in the shadow and distorted in such practices as sexual masochism. Her paper also offers several avenues of exploration for further studies in connection with the phenomenon of masochism, including sexual perversion (‘paraphilia’), chronic psychological victimhood, PTSD and traumatology, religious extremist behaviour such as self‐flagellation, transformation in the individuation process and numinous experience. An extension of her hypothesis to include religious problems of modernity is suggested. 相似文献
88.
89.
In this study, we investigated patients with focal neurodegenerative diseases to examine a formal linguistic distinction between classes of generalized quantifiers, like "some X" and "less than half of X." Our model of quantifier comprehension proposes that number knowledge is required to understand both first-order and higher-order quantifiers. The present results demonstrate that corticobasal degeneration (CBD) patients, who have number knowledge impairments but little evidence for a deficit understanding other aspects of language, are impaired in their comprehension of quantifiers relative to healthy seniors, Alzheimer's disease (AD) and frontotemporal dementia (FTD) patients [F(3,77)=4.98; p<.005]. Moreover, our model attempts to honor a distinction in complexity between classes of quantifiers such that working memory is required to comprehend higher-order quantifiers. Our results support this distinction by demonstrating that FTD and AD patients, who have working memory limitations, have greater difficulty understanding higher-order quantifiers relative to first-order quantifiers [F(1,77)=124.29; p<.001]. An important implication of these findings is that the meaning of generalized quantifiers appears to involve two dissociable components, number knowledge and working memory, which are supported by distinct brain regions. 相似文献
90.
Craske MG Roy-Byrne P Stein MB Sullivan G Hazlett-Stevens H Bystritsky A Sherbourne C 《Behavior Therapy》2006,37(2):112-119
A hybrid efficacy-effectiveness design in which participants (n = 91/93) were retained in the study regardless of whether or not they received treatment enabled evaluation of CBT intensity in relation to panic disorder in the primary care setting. CBT intensity was operationalized as number of cognitive-behavioral therapy sessions, number of follow-up booster phone calls, and secondarily, as number of cognitive behavioral coping and exposure strategies. Baseline psychosocial and demographic predictors of CBT intensity were analyzed first. Severity of anxiety sensitivity predicted number of cognitive behavioral sessions, but no baseline variables predicted number of follow-up booster phone calls or number of coping and exposure strategies. Multivariate logistic and linear regressions were used to evaluate the degree to which treatment intensity predicted 3-month and 12-month outcomes (anxiety sensitivity, phobic avoidance, depressive symptoms, disability, and medical and mental health functioning) after controlling for potential confounding baseline variables. Number of cognitive behavioral therapy sessions predicted lower anxiety sensitivity at 3 and 12 months, and number of follow-up booster phone calls predicted lower anxiety sensitivity, less phobic avoidance, and less depression at 12 months. These findings indicate that "dose" of psychotherapy was an important predictor of outcome. The significance of follow-up booster phone contact is discussed as an index of continued self-management of panic and anxiety following acute treatment. 相似文献