Hippocampal synaptic plasticity during instrumental learning

present research examined the role of hippocampal NMDA-dependent synaptic potentiation on appetitive instrumental conditioning under a continuous reinforcement schedule. In the first experiment, low (.025 mg.kg) or moderate (.05 mg/kg) dosages of the NMDA receptor antagonist, MK801, failed to increase the number of training days required to reach acquisition criterion; number of training days required to reach criterion for extinction were also unaffected. In the second experiment, a higher dosage (.10 mg/kg) of MK801 or induction of long-term potentiation failed to alter the number of responses occurring during acquisition. These data suggest that hippocampal synaptic potentiation does not play a prominent role in instrumental learning with simple contingency conditions. It is suggested that hippocampal LTP reflects a perceptual process that contributes differentially to spatial cognition, classical and instrumental conditioning.     

Hippocampal synaptic plasticity during instrumental learning

present research examined the role of hippocampal NMDA-dependent synaptic potentiation on appetitive instrumental conditioning under a continuous reinforcement schedule. In the first experiment, low (.025 mg.kg) or moderate (.05 mg/kg) dosages of the NMDA receptor antagonist, MK801, failed to increase the number of training days required to reach acquisition criterion; number of training days required to reach criterion for extinction were also unaffected. In the second experiment, a higher dosage (.10 mg/kg) of MK801 or induction of long-term potentiation failed to alter the number of responses occurring during acquisition. These data suggest that hippocampal synaptic potentiation does not play a prominent role in instrumental learning with simple contingency conditions. It is suggested that hippocampal LTP reflects a perceptual process that contributes differentially to spatial cognition, classical and instrumental conditioning.     

The nature and treatment of social phobia in youth

A small proportion of children and adolescents experience a debilitating level of social anxiety, known as social phobia. Initially, we consider the phenomenology and aetiology of social phobia in children and adolescents. A number of age-sensitive assessment instruments or tools are briefly considered: a diagnostic interview, selj-report instruments, behavioural observations, cognitive assessment, self-monitoring and psychophysiological recording. We explore cognitive-behavioural strategies that have been found to be useful in the management of social phobia. Although there is much research support for the efficacy of cognitive-behavioural strategies for adults with social phobia, it is emphasized that controlled evaluations have yet to be undertaken with socially phobic youngsters.     

Three- and four-year-olds’ perceptual confusions for spoken words

Although infants have the ability to discriminate a variety of speech contrasts, young children cannot always use this ability in the service of spoken-word recognition. The research reported here asked whether the reason young children sometimes fail to discriminate minimal word pairs is that they are less efficient at word recognition than adults, or whether it is that they employ different lexical representations. In particular, the research evaluated the proposal that young children’s lexical representations are more “holistic” than those of adults, and are based on overall acoustic-phonetic properties, as opposed to phonetic segments. Three- and four-year-olds were exposed initially to an invariant target word and were subsequently asked to determine whether a series of auditory stimuli matched or did not match the target. The critical test stimuli were nonwords that varied in their degree of phonetic featural overlap with the target, as well as in terms of the position(s) within the stimuli at which they differed from the target, and whether they differed from the target on one or two segments. Data from four experiments demonstrated that the frequency with which children mistook a nonword stimulus for the target was influenced by extent of featural overlap, but not by word position. The data also showed that, contrary to the predictions of the holistic hypothesis, stimuli differing from the target by two features on a single segment were confused with the target more often than were stimuli differing by a single feature on each of two segments. This finding suggests that children use both phonetic features and segments in accessing their mental lexicons, and that they are therefore much more similar to adults than is suggested by the holistic hypothesis.     

Vasopressin, glucose homeostasis, and sucrose taste preferences

Previous research indicates that vasopressin-containing (LE) rats are capable of adapting to the stress of food restriction, whereas vasopressin-deficient (DI) rats cannot adapt to this stressor. It has been postulated that abnormalities in glucose metabolism may be one of the factors leading to the demise of food-restricted DI rats. The present study was conducted to determine if taste preferences are altered in DI animals and if the presentation of exogenous glucose, in the form of sucrose solutions, can ameliorate the effects of the stress of food restriction. Four different concentrations of sucrose solutions were presented to LE and DI rats under the food-restricted condition. In both strains, an 8% sucrose solution was preferred over 0%, 16%, and 32% concentrations, with DI rats consuming more of this concentration than LE rats. Thus, when DI rats had the opportunity of maintaining glucose homeostasis by exogenous supplements, they maintained body weight, displayed no stomach pathology, and survived.     

Sexual responding of “nonrapists” to aggressive sexual themes: Normative data

The present study presents data relevant to the sexual responding to aggressive cues of a large sample of nonrapist males recruited from the community. Two hundred three subjects received physiological assessment of sexual arousal to heterosexual and rape stimuli. Results indicated that under instructions not to interfere with sexual responding, approximately 80% of the nonrapists would be correctly classified, which was significantly different from chance. However, under instructions to suppress arousal, classification was no better than chance. The rape index was not related to age, socioeconomic status, sexual experience, or amount of arousal shown in the laboratory. However, there was a small but significant relationship to IQ. Overall, the data suggest that for instructions not to interfere with responding, the error rate seen in this larger-scale sample was equivalent to that in previous studies using smaller normative samples and that classification in general is not biased by the subject characteristics measured in this study.Portions of this project were supported by USPHS Grant MH-34030-02 from the Center for the Studies of Crime and Delinquency and by Tennessee Department of Mental Health and Mental Retardation Research Contract ID-0783 to the Department of Psychiatry.     

Measurement error in direct observations: a comparison of common recording methods

Videotapes of three brief duration, three medium duration and three long duration types of stereotyped behaviour (of eight severely retarded children) were analysed to provide a criterion record of the true percentage duration of the behaviour. The criterion record was compared with the records produced by four time-sampling methods: a whole-interval method, two partial-interval methods and a momentary time-sampling method. As predicted, the whole-interval method grossly underestimated and the partial-interval methods grossly overestimated the true percentage duration of the behaviour, except when the duration of individual responses was much longer than the observation interval. Momentary time-sampling was not an errorless method but was consistently superior to the other methods.The implications of these findings for the detection of treatment effects by direct observations are discussed.     

The effects of a response cost treatment tactic on hyperactive children

In a pilot study, a multielement design was used to assess the effectiveness of a response cost procedure on a 7-year-old child's hyperactive behavior and academic performance across days. The procedure was effective in reducing off-task behavior and in increasing academic assignment completion. In Experiment 2, three strategies were compared to a no-treatment baseline in treating an 8-year-old hyperactive child: drug (Ritalin) alone, response cost alone, and drug plus response cost. The cost program alone and the cost program combined with medication were effective in reducing off-task behavior and in increasing academic performance. In both studies, the procedure was viewed by the teachers as practical and effective for use in a classroom setting. The subjects liked the cost system and believed that they completed more academic work when it was operative.     

The pursuit of the minor premise a commentary on normality

In this paper are explored the ethical implications of the answers to three questions: Whether or not a diseased state is discrete; the criteria by which that question is answered; and how the diseased state is to be identified. Examples are given showing that some states appear to be clearly discrete, and others equally clearly not discrete. The nature of the pertinent evidence will be affected accordingly. It is shown that a slavish and inappropriate concern with categories leads to anomalous ethics. Finally, it is suggested that many of these problems may be avoided by centering the ethics of medicine on optimizing the welfare of the patient rather than by thinking in terms of categorical disease.