Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteins

Experience-dependent plasticity is thought to involve selective change in pre-existing brain circuits, involving synaptic plasticity. One model for looking at experience-dependent plasticity is environmental enrichment (EE), where animals are exposed to a complex novel environment. Previous studies using electron microscopy showed that EE resulted in synaptic plasticity in the visual cortex and hippocampus. However, the areas in the brain that have been examined following EE have been limited. The present study quantified potential synaptic plasticity throughout the brains of C57BL/6 mice using an enzyme-linked immunosorbent assay (ELISA) for two synaptic proteins, synaptophysin and PSD-95. EE resulted in increased synaptophysin and PSD-95 levels through major brain regions, including anterior and posterior areas of the forebrain, hippocampus, thalamus, and hypothalamus. However, no changes in synaptophysin were detected in the cerebellum. These results demonstrate that EE results in an increase in levels of both pre- and post-synaptic proteins in multiple regions of the brain, and it is possible that such changes represent the underlying synaptic plasticity occurring in EE.     

Ecclesial DNA

We discuss here the metaphor of church DNA which has been used in arguments against Called to Common Mission. Consideration of the role of the genetic material in biological organisms enables us to suggest what it might mean to say that the DNAs of different Christian traditions are or are not compatible. As plants or animals belong to the same species if they can propagate their kind, church bodies can be said to be compatible if their inter‐communion furthers the church's mission to make disciples. Some ways in which ecumenical agreements might make this possible are considered.     

The relationship between children's self-reported recess problems, and peer acceptance and friendships

This study used three samples to investigate the nature of children's self-reported recess problems and the degree to which these were correlated with children's peer acceptance and mutual friendships. Results suggest that seven student complaints about recess can be grouped into problems with peer conflict and problems with social inclusion. Modest relations were reported between inclusion recess problems and children's mutual friendships and peer acceptance. Relations of conflict recess problems with mutual friendships and peer acceptance were less frequent. Results suggest that self-reported recess problems are a distinct construct from traditional research measures of peer acceptance and friendships.     

On Fodor's First Law of the Nonexistence of Cognitive Science

In his enormously influential The Modularity of Mind, Jerry Fodor (1983) proposed that the mind was divided into input modules and central processes. Much subsequent research focused on the modules and whether processes like speech perception or spatial vision are truly modular. Much less attention has been given to Fodor's writing on the central processes, what would today be called higher‐level cognition. In “Fodor's First Law of the Nonexistence of Cognitive Science,” he argued that central processes are “bad candidates for scientific study” and would resist attempts at empirical analysis. This essay evaluates his argument for this remarkable claim, concluding that although central processes may well be “messier” than input modules, this does not mean that they cannot be studied and understood. The article briefly reviews the scientific progress made in understanding central processes in the 35 years since the book was published, showing that Fodor's prediction is clearly falsified by massive advances in topics like decision making and analogy. The essay concludes that Fodor's Law was not based on a clear argument for why the complexities of central systems could not be studied but was likely based on intuitions and preferences that were common in psychology at the time.     

Jus Ad Bellum,Values, and the Contemporary Structure of International Law

In “Religion, Violence, and Human Rights: Protection of Human Rights as Justification for the Use of Armed Force,” James Johnson discusses an important dilemma for contemporary society: when should transnational military force be permitted to protect human rights? Professor Johnson uses the relatively recent doctrine of a “responsibility to protect” as the centerpiece of his paper, characterizing it as a reaction to legal concepts that emerged in the “Westphalian system.” Yet the doctrine, at least as it relates to the use of military force, is not a reaction to that system but, rather, to the relatively recent system of the UN Charter, particularly its relegation to the Security Council of the exclusive authority to determine when military force should be used for purposes other than self‐defense. When the Cold War ended and the Security Council failed to act to protect human rights, the doctrine was born.     

Reconstruction of arbitrary versus logical sequences by preschool children

The ability of preschool children to construct and reconstruct ordered sequences was examined in a series of four experiments. In Expt. 1, the task was to copy, with the model present or absent, the order of items pegged on a clothesline. In Expts. 2–4, the subjects were required to reconstruct ordered series of pictures from memory. In all experiments, the orders were either logical or arbitrary. Reconstruction of an arbitrary series of events is within the problem solving capacity of 4-yr-old children if (a) reconstruction takes place in the presence of the model or follows immediately upon the removal of the model and (b) the original sequence is presented simultaneously. If, however, the lag between viewing and reconstruction is increased and/or the original set is not viewed simultaneously, as a unit, performance declines. The provision of an inherent order to the items within a set, either by introducing a connective narrative, or a depicted logical sequence, is sufficient to maintain that order over time and to provide a unifying cohesion to the items when viewed successively.     

Description of a restricted randomization program (RRP)

A computer program, which produces restricted randomizations of numbers as an aid in counterbalancing large experimental designs, is described. The input to the program is a series of specifications for sampling a pool of random numbers. For example, it might be specified that each number in the pool be selected at least once and not more than twice in each replication of the experiment. The output would be a restricted randomization meeting these specifications. The program has been used in several memory experiments and could be used in other experimental paradigms in learning and perception.