医学的“死亡”背景与现代医学对死亡的遗忘

人是一种承担着有死性的存在物,一切从人出发并为了人的事业都必须在"人固有一死"的背景中进行。首先阐述了死亡对于医学的背景意义:死亡是人类面临的客观的、必要的限制,关于死亡的立场对于医学具有源始性与优先性,最后从三个方面揭示了当代医学对于死亡的立场:遗忘。     

Identity and semantic negative priming in rapid serial visual presentation streams

In selective attention tasks, the efficiency of processing concurrently presented target and distractor stimuli in a given display is often influenced by the relationship these stimuli have with those in the previous display. When a to-be-attended target on a current trial (the probe trial) matches the ignored, non-target distractor on a previous trial (the prime trial), a response to the target is typically delayed compared with when the two stimuli are not associated. This negative priming (NP) phenomenon has been observed in numerous studies with traditional NP tasks presenting the target and distractor simultaneously in both the prime and probe trial couplets. Here, however, in four experiments using a mixture of stimulus types (letters, digits, English number words, and logographic Chinese number words), target and distractor stimuli were temporally separated in two rapid serial visual presentation (RSVP) streams instead of concurrently presented. The findings provide a conceptual replication and substantial extension of a recent study by Wong (Plos One, 7, e37023, 2012), and suggest that active suppression of irrelevant distracting information is a more ubiquitous form of cognitive control than previously thought.     

Shared and distinct factors driving attention and temporal processing across modalities

In addition to the classic finding that “sounds are judged longer than lights,” the timing of auditory stimuli is often more precise and accurate than is the timing of visual stimuli. In cognitive models of temporal processing, these modality differences are explained by positing that auditory stimuli more automatically capture and hold attention, more efficiently closing an attentional switch that allows the accumulation of pulses marking the passage of time (Penney, Gibbon, & Meck, 2000). However, attention is a multifaceted construct, and there has been little attempt to determine which aspects of attention may be related to modality effects. We used visual and auditory versions of the Continuous Temporal Expectancy Task (CTET; O'Connell et al., 2009) a timing task previously linked to behavioral and electrophysiological measures of mind-wandering and attention lapses, and tested participants with or without the presence of a video distractor. Performance in the auditory condition was generally superior to that in the visual condition, replicating standard results in the timing literature. The auditory modality was also less affected by declines in sustained attention indexed by declines in performance over time. In contrast, distraction had an equivalent impact on performance in the two modalities. Analysis of individual differences in performance revealed further differences between the two modalities: Poor performance in the auditory condition was primarily related to boredom whereas poor performance in the visual condition was primarily related to distractibility. These results suggest that: 1) challenges to different aspects of attention reveal both modality-specific and nonspecific effects on temporal processing, and 2) different factors drive individual differences when testing across modalities.     

三支论式及因明学说实质之辨析

本文从卢卡西维茨关于亚氏三段论的分析出发,针对学术界中“三支论式”是三段论推理、充分条件假言推理、假言转为三段论推理或外设三段论推理等观点,从工具的使用到工具的锻造这一角度,进行了分析研究。笔者提出了一些与传统看法不同的观点,并在此基础上得出了“三支论式”及因明学说的实质是论证而不是推理的新见解。     

Every moment counts: smooth transitions of object boundaries reflect constant updating in object-based attention

Detection of a target is faster when it is presented on an attended rather than an unattended object (i.e., object-based attention). Using the double-rectangle cuing paradigm (Egly, Driver, & Rafal, 1994), we previously showed that object-based attention operates on a dynamic representation: Object-based attentional guidance is affected by subsequent changes occurring to an attended object (Lin & Yeh, 2011). The present study provides further support for our dynamic-updating hypothesis, demonstrating that changes are indeed updated into the existing object representation. After a cue display, we introduced changes between the initial display (four hashes) and the final display (four squares with an occluder between them). We found object-based attention only with smooth transitions between the initial and final displays, not when transitions were in the reverse order (Exp. 1) or contained any single disruption of the smooth transition (Exp. 2). These results confirm our hypothesis that attention operates on a dynamic object representation that is constantly and continuously updated.     

Encoding specific associative memory: evidence from behavioral and neural manipulations

Within-subjects procedures with rats assessed the associative structures acquired during conditioning trials in which the interval between the stimuli and food was either short or long (i.e., A-10 s→food and B-40 s→food). In Experiments 1 and 2, after these conditioning trials, A and B served as second-order reinforcers for 2 further stimuli (i.e., X→A and Y→B); whereas Experiment 3 used a sensory preconditioning procedure in which X→A and Y→B trials occurred before the conditioning trials, and rats were finally tested with X and Y. In each experiment, Y elicited greater responding at test than did X. This finding supports the contention that the long-lived trace of B (associated with food on B-40 s→food trials) is more similar to the memory of B that was associatively provoked by Y, than is the short-lived trace of A (associated with food on A-10 s→food trials) to the memory of A that was associatively provoked by X. These conclusions were reinforced by the effects of a neural manipulation that disrupted discrimination learning involving the short traces of stimuli but not the long traces of the same stimuli.     

Decision making in children and adolescents: impaired Iowa Gambling Task performance in early adolescence

Disadvantageous decision making is cited as one of the premier problems in childhood development, underlying risky behavior and causing adolescents to make poor choices that could prove detrimental later in life. However, there are relatively few studies looking at the development of decision making in children and adolescents, and fewer still comparing it with the performance trajectories of more typically developing cognitive functions. In the current study, we measured the affective decision-making abilities of children and adolescents 8- to 17-years-old using the Iowa Gambling Task (IGT; Bechara, 2007) in conjunction with a battery of established cognitive neuropsychological assessments. In contrast to the typical linear development of executive functions, affective decision-making abilities progressed in a J-shaped curve. Younger, more developmentally naive children performed better on the IGT than older, early-adolescent individuals, with performance becoming advantageous again toward the end of the teenage years. This trajectory is thought to coincide with asymmetric neural development in early adolescents, with relatively overactive striatal regions creating impulsive reward-driven responses that may go unchecked by the slower developing inhibitive frontal cortex. This trajectory is in stark contrast with the linear development of memory, speed of processing, and other cognitive abilities over the ages.     

主观幸福感的结构及其与人格特质的关系

以239名大学生为被试,考察了主观幸福感(SWB)的结构及其与人格特质的关系。分析表明,SWB由生活满意度、积极情感和消极情感三个相关的维度构成,而且它们可以共同负荷于一个高阶因子。外倾和神经质是SWB的重要预测指标,积极情感的主要预测指标是外倾,神经质则是消极情感最有力的预测指标,而外倾和神经质对消极情感和生活满意度有相同的预测力。情感平衡是外倾和神经质影响生活满意度的中介变量。     

胡煦与朱熹对"太极""道器"理解之分歧

胡煦是清初一位重要的易学家、理学家,他的思想有很多独到之处,持论酌于汉学、宋学之间,与朱子颇有异同.朱熹认为太极即是理,把理看作是万物的本体.胡煦则认为太极是本体,理只是其用,太极不仅立于形器之先,也在理之先.朱熹以理为形上之道,而以阴阳为形下之器.胡煦认为"一阴一阳之谓道",则阴阳应为形上之道,道与阴阳实为一也.胡煦与朱熹对"太极""道器"等概念理解的差异反映了清初学术界思想的转向.     

Reduced or increased influence of non-pertinent information in patients with schizophrenia?

We tested the ability of 18 patients with schizophrenia and 18 matched controls to filter non-pertinent information in orientation matching tasks. The non-pertinent information consisted of pictures conveying semantic information. The pertinent information consisted of oriented line-segments drawn inside pictures or was represented by the overall orientation of the picture itself. The results showed that non-pertinent information interfered with performance of control subjects in all tasks. In contrast, non-pertinent information interfered with the performance of patients with schizophrenia to the same extent as that of matched controls only when non-pertinent and pertinent information was physically mingled, but not when they were separated. Yet, patients processed non-pertinent information in all experiments, as shown by reversed interference effects when non-pertinent and pertinent information was physically separated. These results suggest a deficit at linking physically distinct visual information in patients with schizophrenia. Additionally, performance was more impaired in patients with schizophrenia than in control subjects when the amount of displayed information increased. The results suggest the coexistence, and a possible relationship between attentional deficits and impairments at linking distinct visual information in patients with schizophrenia.