‘Age-hardened alloy’ based on bulk polycrystalline oxide ceramic

We report here for the first time the development of ‘age-hardened/toughened’ ceramic alloy based on MgO in the bulk polycrystalline form. This route allows for the facile development of a ‘near-ideal’ microstructure characterized by the presence of nanosized and uniformly dispersed second-phase particles (MgFe₂O₄) within the matrix grains, as well as along the matrix grain boundaries, in a controlled manner. Furthermore, the intragranular second-phase particles are rendered coherent with the matrix (MgO). Development of such microstructural features for two-phase bulk polycrystalline ceramics is extremely challenging following the powder metallurgical route usually adopted for the development of bulk ceramic nanocomposites. Furthermore, unlike for the case of ceramic nanocomposites, the route adopted here does not necessitate the usage of nano-powder, pressure/electric field-assisted sintering techniques and inert/reducing atmosphere. The as-developed bulk polycrystalline MgO–MgFe₂O₄ alloys possess considerably improved hardness (by ~52%) and indentation toughness (by ~35%), as compared to phase pure MgO.     

If We Build It … Will They Come? – Establishing a Cancer Genetics Services Clinic for an Underserved Predominantly Latina Cohort

Background: Cancer genetic counseling and testing is a standard of care option for appropriate families and can identify individuals at increased risk prior to diagnosis, when prevention or detection strategies are most effective. Despite documented efficacy of cancer risk reduction in high-risk individuals, underserved and minority individuals have a disproportionate cancer burden and limited access to genetic counseling. Methods: A needs assessment survey documented gaps in knowledge and interest in prevention. Satellite clinics were established at two indigent healthcare systems. Cancer genetics CME lectures were conducted and referral guidelines disseminated to clinicians who referred patients for counseling. Results: An increase in clinician knowledge was demonstrated post-CME and reflected by quality referrals. Eighty-eight percent of patients kept their appointments. In the predominantly Latina⁶ (n=77) clinic population, 71.4% were affected with cancer, and 17 mutation positive families were identified. Preliminary data shows a positive impact on patients' motivation and behavior. The majority has expressed satisfaction and reduction in anxiety. Conclusions: This study demonstrates feasibility and acceptability of cancer genetics services in this population, suggesting the potential to reduce cancer morbidity in underserved, high-risk families.“Latino” is the most common census term for individuals of Spanish, Mexican, Central and South American, Cuban, or Puerto Rican descent, referring to ethnicity, and is generally considered a more ethnically/culturally based term for individuals of the aforementioned groups. As this cohort is female the feminine noun “Latina” is used     

Development and use of behavior and social interaction software installed on Palm handheld for observation of a child’s social interactions with the environment

In settings in developing countries, children often socialize with multiple socializing agents (peers, siblings, neighbors) apart from their parents, and thus, a measurement of a child’s social interactions should be expanded beyond parental interactions. Since the environment plays a role in shaping a child’s development, the measurement of child-socializing agents’ interactions is important. We developed and used a computerized observational softwareBehavior and Social Interaction Software (BASIS) with a preloaded coding scheme installed on a handheld Palm device to record complex observations of interactions between children and socializing agents. Using BASIS, social interaction assessments were conducted on 573 preschool children for 1 h in their natural settings. Multiple screens with a set of choices in each screen were designed that included the child’s location, broad activity, state, and interactions with child-socializing agents. Data were downloaded onto a computer and systematically analyzed. BASIS, installed on Palm OS (M-125), enabled the recording of the complex interactions of child-socializing agents that could not be recorded with manual forms. Thus, this tool provides an innovative and relatively accurate method for the systematic recording of social interactions in an unrestricted environment.     

Defense Mechanisms in Mania,Bipolar Depression and Unipolar Depression

The present study compared the use of defense mechanisms in ten bipolar manic, ten bipolar depressed and ten unipolar depressed patients. The defense mechanisms were assessed by two methods: TAT stories scored by Defense Mechanism Manual and Defense Mechanism Rating Scale ratings of psychodynamic interviews. The severity of symptoms was assessed by Beck Depression Inventory for depressed patients and Young’s Manic Rating Scale for manic patients. Both bipolar manic and depressed groups used the defense mechanism of denial, borderline level defenses and immature defenses significantly more than the unipolar depression group. The manic group showed greater dependence on narcissistic level defenses as compared to the other two groups. Positive relationships were found between severity of manic symptoms and the defense mechanisms of denial as well as the narcissistic level defenses. The bipolar depression group also used more action level defenses as compared to the unipolar depression group. The unipolar depression group scored higher on the defense mechanism of identification and adaptive level defenses as compared to the manic group. A negative correlation was found between the severity of depressive symptoms for unipolar depression group and the defense mechanism of identification. The neurotic level defenses were used most frequently by unipolar depression group, followed by the bipolar depression group and manic group. Some of these findings are in consonance with the psychoanalytic understanding of mania and depression.     

Associations between cortical thickness and general intelligence in children,adolescents and young adults

Neuroimaging research indicates that human intellectual ability is related to brain structure including the thickness of the cerebral cortex. Most studies indicate that general intelligence is positively associated with cortical thickness in areas of association cortex distributed throughout both brain hemispheres. In this study, we performed a cortical thickness mapping analysis on data from 182 healthy typically developing males and females ages 9 to 24 years to identify correlates of general intelligence (g) scores. To determine if these correlates also mediate associations of specific cognitive abilities with cortical thickness, we regressed specific cognitive test scores on g scores and analyzed the residuals with respect to cortical thickness. The effect of age on the association between cortical thickness and intelligence was examined. We found a widely distributed pattern of positive associations between cortical thickness and g scores, as derived from the first unrotated principal factor of a factor analysis of Wechsler Abbreviated Scale of Intelligence (WASI) subtest scores. After WASI specific cognitive subtest scores were regressed on g factor scores, the residual score variances did not correlate significantly with cortical thickness in the full sample with age covaried. When participants were grouped at the age median, significant positive associations of cortical thickness were obtained in the older group for g-residualized scores on Block Design (a measure of visual-motor integrative processing) while significant negative associations of cortical thickness were observed in the younger group for g-residualized Vocabulary scores. These results regarding correlates of general intelligence are concordant with the existing literature, while the findings from younger versus older subgroups have implications for future research on brain structural correlates of specific cognitive abilities, as well as the cognitive domain specificity of behavioral performance correlates of normative gray matter thinning during adolescence.     

Structural investigations on Nd-doped silica nanocomposites: effect of sintering temperature and dopant concentration

Neodymium-doped silica nanocomposites were prepared from an acid-catalysed sol–gel solution followed by heat treatment. The structural and microstructural properties of the prepared samples as a function of sintering temperature and Nd concentration are reported. Fourier transform infrared spectra show that phase separation occurs during heat treatment. The presence of Nd₂O₃ and α-Nd₂Si₂O₇ phases in the samples was established by X-ray diffraction (XRD), and transmission electron microscopy (TEM) micrographs revealed the microstructure of the nanocomposites. From XRD patterns, the crystallite size was determined using the Debye–Scherrer formula, while the particle size was estimated from TEM micrographs. The results suggest that sintering at high temperature enhances the crystallinity and density of Nd₂O₃–SiO₂ nanocomposites, while the high concentration of neodymium prevents the crystallization of SiO₂.     

Haunted by somatic tendencies: Spirit infestation as psychogenic illness

It has been suggested that haunting and poltergeist episodes are akin to outbreaks of contagious psychogenic illness. Therefore, it might be expected that hypochondriacal and somatic tendencies would significantly predict self-reported experiences of 'spirit infestation' and other paranormal ideations. This prediction was tested on a sample of 314 undergraduate students who completed the Anomalous Experiences Inventory, the Transliminality Scale and three standard questionnaires about hypochondriasis, somatic complaints, and cognitions about body and health. Results from correlational and regression analyses supported predictions, although we found that the type of bodily cognition varied with the specificity of the paranormal experience. For example, indices of spirit infestation coincided with autonomic sensations, perceived paranormal ability was related to catastrophizing cognitions, and general paranormal experiences correlated with somatization traits. Transliminality and paranormal belief contributed positively to nearly all of these associations. These findings are consistent with the idea that some paranormal experiences are partly misattributions of internal experience to external (paranormal) sources - a process that could initiate an episode of contagious (mass) psychogenic illness by encouraging the collective perception of similar 'symptoms' in a group of people due to suggestion and demand characteristics.     

Self-Other Discrepancies in Waiting Time Decisions

Both anecdotal evidence and recently reported research suggest that people are risk-averse when faced with waiting time decisions. Four studies investigate whether there is a self-other discrepancy in how people make waiting time decisions themselves and how they predict others will make similar decisions. People are found to believe that others have valuations of time similar to their own. However, when faced with alternatives that involve risk in the duration of the wait, the results point to a self-other discrepancy, in that people report greater risk-aversion themselves than they think others would. Further, when faced with waiting time gains, people are themselves more risk-averse than they think others would be. Conversely, when faced with waiting time losses, people are themselves more risk-seeking than they think others would be. Overall, the results are consistent with the recently proposed risk-as-feelings hypothesis.