The Perceived Advantages and Disadvantages of Presymptomatic Testing for Machado-Joseph Disease: Development of a New Self-Response Inventory

This study describes the construction of a self-response inventory to evaluate the perception of advantages and disadvantages of the Machado-Joseph disease presymptomatic testing, in 44 individuals at-risk for this disease. The results showed that the reliability of this inventory was satisfactory. Factor analysis revealed a bidimensional structure: perceived advantages (pros) and perceived disadvantages (cons) of presymptomatic testing. Social desirability was found unrelated to the total scores of our inventory. Additional correlation studies, with other scales, confirmed the convergent validity of the instrument. These results suggest adequate construct validity. This inventory thus seems to be a proper instrument to assess expectations involved in the decision-making process of Machado-Joseph disease presymptomatic testing.     

Effects of subchronic administration of gammahydroxybutyrate (GHB) on spatial working memory in rats

GHB, a popularly known drug as "liquid ecstasy", is a substance with abuse potential. Among the possible described side-effects after the continued consumption of GHB are amnesia and deterioration of memory. Likewise, recent studies indicate the existence of neurotoxicity in certain brain regions after its prolonged treatment. The aim of this study was to examine the effect of the subchronic administration of GHB (10 and 100 mg/kg) on spatial memory and sensoriomotor reflexes in male rats, using the Morris water maze and a battery of sensoriomotor tests, respectively. The results indicated that animals treated with GHB (10 mg/kg) showed a greater latency of escape during the phase of acquisition in the days first and third of tests, as compared with the control group (p<0.05), as well as a deterioration of grasping reflex with the two doses of GHB (p<0.01). Numerous studies indicated that the medial prefrontal cortex is a crucial neuronal substrate in the working memory and grasping reflex modulation. These results suggest that prolonged administration of GHB could alter structure and/or function of the medial prefrontal cortex, as well as its interconnections with other brain regions involved in the evaluated cognitive and neurological processes.     

Depression secondary prevention in primary care

In order to analyse efficacy, effectiveness and efficiency of several depression secondary prevention programs, three group interventions were developed in Primary Care Centres: cognitive-behavioral therapy, promotion of one's coping resources therapy (just paying attention to abilities, without training) and social support. The sample was composed by 60 people with from-mild-to-moderate depressive symptoms, who were randomly assigned either to any of the treatments or to a control group (waiting list). Psychopathology, quality of life and attendance to mental health services variables were assessed at pretest, posttest and two follow-up evaluations, 6 and 12 months afterwards. Outcomes: both therapies had more efficacy, effectiveness and efficiency compared to the social support group, and this one was better than the waiting list.     

Lexical selection in bilingual speech production does not involve language suppression

The "hard problem" in bilingual lexical access arises when translation-equivalent lexical representations are activated to roughly equal levels and, thus, compete equally for lexical selection. The language suppression hypothesis (D. W. Green, 1998) solves this hard problem through the suppression of lexical representations in the nontarget language. Following from this proposal is the prediction that lexical selection should take longer on a language switch trial because the to-be-selected representation was just suppressed on the previous trial. Inconsistent with this prediction, participants took no longer to name pictures in their dominant language on language switch trials than they did on nonswitch trials. These findings indicate that nontarget lexical representations are not suppressed. The authors suggest that these results undermine the viability of the language suppression hypothesis as a possible solution to the hard problem in bilingual lexical access.     

Retrieval induces hippocampal-dependent reconsolidation of spatial memory

Nonreinforced retrieval can cause extinction and/or reconsolidation, two processes that affect subsequent retrieval in opposite ways. Using the Morris water maze task we show that, in the rat, repeated nonreinforced expression of spatial memory causes extinction, which is unaffected by inhibition of protein synthesis within the CA1 region of the dorsal hippocampus. However, if the number of nonreinforced retrieval trials is insufficient to induce long-lasting extinction, then a hippocampal protein synthesis-dependent reconsolidation process recovers the original memory. Inhibition of hippocampal protein synthesis after reversal learning sessions impairs retention of the reversed preference and blocks persistence of the original one, suggesting that reversal learning involves reconsolidation rather than extinction of the original memory. Our results suggest the existence of a hippocampal protein synthesis-dependent reconsolidation process that operates to recover or update retrieval-weakened memories from incomplete extinction.     

Amnestic effect of intrahippocampal AM251, a CB1-selective blocker, in the inhibitory avoidance, but not in the open field habituation task, in rats

CB1 is the most abundant metabotropic receptor of the brain, being found in areas classically involved in learning and memory and present at higher density at presynaptic terminals. Different sets of evidence support the idea that endogenous ligands (endocannabinoids) to the CB1 receptors act as modulators of neurotransmission. In hippocampus, endocannabinoids seem to act as retrograde messengers mediating down-regulation of GABA release. Previous reports have described a cognitive impairment effect of cannabinoid agonists, or facilitation by antagonists. The scope of the present study is to investigate the effect of intrahippocampal administration of the CB1-selective antagonist, AM251, in two behavioral tasks. One hundred and twelve male Wistar rats with bilateral cannulae implanted in the CA1 region of the dorsal hippocampus were trained in a step-down inhibitory avoidance task (IA, footshock, 0.5 mA) or an open field habituation task (OF). Immediately, after training, animals received an infusion of 0.55, 5.5, and 55.5 ng/side of AM251 (Tocris), or its vehicle (DMSO/saline), via these cannulae. Our results show that AM251 disrupted memory consolidation of the IA task, but not the OF task, an effect that seems to be purely mnemonic since the drug showed no motor performance effects. Only the intermediate dose (5.5 ng/side) of AM251 was effective in IA and the absence of effect with the larger dose may be the consequence of non-specific binding. The fact that OF was not affected raises the possibility that this endogenous system requires some degree of aversiveness to be recruited. We propose that increased levels of endogenous cannabinoids in the hippocampus, following a training session, contribute to facilitate memory consolidation, a process that may have been disrupted with AM251.     

Suárez and the doctrine of the transcendentals

This article discusses Suárez's views concerning the transcendentals, that is, being and those attributes of it that extend to everything. In particular it explores Suárez's notion of transcendentality and the way in which he conceived the transcendental attributes of being are related to it. It makes two claims: First, that Suárez has an intensional, rather than an extensional understanding of transcendentality; and, second, that Suárez's understanding of truth and goodness, as expressing real extrinsic denominations based on real relations, appears to contain an inconsistency.I am grateful to Jane Bristol, John Doyle, and Scott MacDonald for their comments on an early draft of this paper.     

Concurrent measurement of heart rate and instrumental avoidance behavior in the Rhesus monkey

A graphical method has been developed for the concurrent recording of heart beats and lever responses during behavioral experiments. The EKG signal fed into any DC amplifier goes to a fixed level trigger circuit and relay driver with its own power supply. The signal from this drives any standard cumulative recorder. Lever response rates are recorded concurrently on an additional cumulative recorder using the same paper speed.     

Is valentine still doubtful? A workshop model for children of divorce

We present this eight-session structured workshop format aimed at school-aged children of divorce who are considered psychologically healthy by family and teachers, in which we review the situations most frequently encountered by these families.In the workshop we offer an understanding vision of divorce while providing the children with the experience of working with therapists who are able to deal with highly troublesome issues in a caring atmosphere.Acknowledgements are expressed to Bernardita Cruz, school counselor, and Ilana Meler and Patricia Tahl, child psychologists.     

Ideology,modernization and politico-economic development in Latin America

The authors state that social and political processes are continuously interrelated and modify each other in a circular fashion. The economic variable seems to be the most independent and strategic one in the complex and circular causal process of contemporary history. Its importance is due to the fact that economic forces have become the means that contribute the most to the attainment of varied social and political goals. holding appointments in the Department of International Relations, Economics, Political Science and Sociology/Anthropology. He is also a Senior Research Scholar at the University of Miami’s Graduate School of International Studies. He has been a Senior Fellow at Brookings Institution and is presently a staff member there. He has published more than thirty books and over one hundred articles.