Enuresis: The beginning work—what really happened

The harmless, inexpensive, and effective method of treating enuresis (bed-wetting) described in this paper was developed more than forty years ago; yet dangerous, brutal, and ineffective methods of toilet training continue to be widely used. This article has therefore been prepared, not only because of historical considerations, but also in the hope of substantially increasing its usage, with benefit to enuretic children (adolescents, even some adults) and their families, far and wide. This article is not copyrighted, and the simple apparatus required for the type of training here described is not patented.     

Intracerebroventricular Administration of Mineralocorticoid Receptor Antisense Oligonucleotides Attenuates Salt Appetite in the Rat

The anterior ventral third ventricle (AV3V) region of the brain contains high concentrations of mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) that are important in the maintenance of body fluid and electrolyte balance as well as other physiological processes. Daily intracerebroventricular pulse injections of MR antisense oligonucleotides significantly suppressed deoxycorticosterone acetate (DOCA) induced salt appetite in a dose-related manner. Similar administration of GR antisense or scrambled/sense oligonucleotide into the third ventricle failed to inhibit salt appetite. Salt appetite aroused after adrenalectomy was not suppressed by MR antisense oligonucleotide treatments but was suppressed by an antisense oligonucleotide directed against the angiotensin II AT1 receptor subtype. Receptor binding analysis demonstrated that MR and GR oligonucleotide treatments each reduced their respective receptor subtypes. Finally, although GR antisense oligonucleotide treatment was ineffective in suppressing DOCA-induced salt appetite, this treatment did increase stress induced corticosterone release as well as delayed the recovery of corticosterone to basal levels after stress.     

Energetic Cost and Stability During Human Walking at the Preferred Stride Velocity

The possibility that preferred modes of locomotion emerge from dynamical and optimality constraints and the energetic and dynamical constraints on preferred and predicted walking frequency are explored in this article. Participants were required to walk on a treadmill at their preferred frequency, at a frequency predicted as the resonance of a hybrid pendulum-spring model of the legs, and at frequencies +/-15%, +/-25%, +/-35% of the predicted frequency. Walking at the preferred and predicted frequencies resulted in minimal metabolic costs and maximal stability of the head and joint actions. Mechanical energy conservation was constant across conditions. The head was more stable than the joints. The joints appeared to be in service of the head in maintaining a stable trajectory. The major findings of this study suggest a complementary relationship between energetic (physiological) and stability constraints in the adoption of a preferred frequency of walking. Multiple subsystems may be involved in constraining observed macroscopic behavior in intact biological systems. The approach and results of the study imply that a useful tack in understanding how dynamical control structures arise is to study the potential criteria that serve to act as constraints on skilled movement patterns in unimpaired and impaired populations.     

Sudden onset of excessive repetitions in the speech of a patient with multiple sclerosis: A case report

This report provides a detailed analysis of excessive part- and whole-word repetitions in the speech of a 36-year-old male patient hospitalized for treatment of multiple sclerosis (MS) who also exhibited concurrent language and prosodic disturbances. Shortly following his hospitalization, a magnetic resonance imaging examination revealed plaques in the white matter of the medulla, cerebellum, basal ganglion, and periventricular white matter. His speech strongly resembled apractic speech patterns, chiefly syllable segregation. The source of data collected for this study was seven tape-recorded speech samples containing 2536 words spoken in 32.75 min, diagnostic reports, and clinical notes of 27 biweekly speech therapy sessions across a 5-month period. This report focused on an analysis of variables associated with the patient's part- and whole-word repetitions, and it was concluded that they were used as a compensatory device to procure additional time to articulate complex syllables. A brief critique of the therapeutic procedures used for treating his speech problem is also presented.

Educational objectives: The reader will learn about and be able to describe (1) the effects of MS on speech and language; (2) the kinds of data that were gathered to account for this patient's sudden onset of speech and language disorders; and (3) the findings that led them to conclude that his excessive repetitions were compensatory behaviors.     

Mechanisms for the cueing phenomenon: The addition of the cueing context to the training memory

A series of three experiments was run to test the hypothesis that when animals are exposed to a cue from prior training, the context in which cueing occurs becomes associated with the training memory. The first experiment demonstrates that when rats are trained to avoid in one context and then are tested in a different context performance is reduced. Experiments 2 and 3 demonstrate that this performance deficit can be alleviated by cueing the rats in the test context prior to testing. The data suggested that the improved performance does not seem to result from the association of the cueing context with a fear response. These results are discussed in relation to the context addition hypothesis.     

Correlates of academic procrastination

Concurrent correlates of academic procrastination were investigated in Israeli college preparatory students (N = 113). Procrastination in one course of study was found to be moderately correlated with procrastination in another, but not to procrastination in the routine tasks of daily living. Evidence for the validity of self-report procrastination scales was the moderate correlation with instructors' ratings. Procrastination was weakly related to emotional upset about it and moderately related to the endorsement of reasons for it—students high in procrastination and emotional upset gave higher reason endorsements (i.e., cited suggested reasons as more reflective of the causes of their procrastination) than the others. Reasons that were judged a priori as less threatening to one's self-esteem received higher endorsements than threatening ones. Contrary to prediction, reasons considered nonthreatening to one's self-esteem were as strongly related to emotional upset and to procrastination as threatening reasons. That students vary in emotional upset about procrastination and in the reasons they give for it highlights the need for comprehensive assessment of students in planning and implementing treatment programs.     

Middle-class adults'' knowledge of referral sources for problems of vision, dentition, reading, stuttering, and articulation

A survey of 40 middle-class adults representing four age groups 10 yrs apart was conducted to determine to whom they would refer children with problems involving vision, dentition, reading, stuttering, and articulation. Results indicate that the adults were well informed with respect to referral sources for treatment of vision and dentition but inconsistencies were noted in choosing referral sources for reading, articulation, and especially stuttering. Implications of these findings are discussed.     

A preliminary investigation of multicultural perspective and life satisfaction

The present study represents a preliminary investigation of Ramirez' contention that developing a multicultural identity would lead to better mental health and more life satisfaction. Using a tentative index of a multicultural perspective analysis indicated that, although a multicultural perspective is associated with more life satisfaction, it accounts for only 8% of the variance. Further, one of the measures used by Ramirez to measure an aspect of a multicultural perspective was not correlated with life satisfaction, and another correlated negatively. This latter measure accounts for only 6% of the variance in life satisfaction. Combined, these findings provide limited support for Ramirez perspective by explaining 14% of the overall variance in life satisfaction.