Reasons for Declining Preconception Expanded Carrier Screening Using Genome Sequencing

Genomic carrier screening can identify more disease-associated variants than existing carrier screening methodologies, but its utility from patients’ perspective is not yet established. A randomized controlled trial for preconception genomic carrier screening provided an opportunity to understand patients’ decisions about whether to accept or decline testing. We administered a survey to potential genomic carrier screening recipients who declined participation (N = 240) to evaluate their reasons for doing so. Two thirds of women declined participation. We identified major themes describing reasons these individuals declined to participate; the most common were time limitation, lack of interest, not wanting to know the information, and potential cause of worry or anxiety. Most women eligible for genomic carrier screening indicated that their reasons for opting out were due to logistical issues rather than opposing the rationale for testing. As expanded carrier screening and genomic sequencing become a more routine part of clinical care, it is anticipated there will be variable uptake from individuals for this testing. Thus, the advancement of clinical carrier screening from single genes, to expanded screening panels, to an exome- or genome-wide platform, will require approaches that respect individual choice to receive genetic testing for reproductive risk assessment.     

Impact of contextual constraint on vocabulary acquisition in reading*

The current study investigated the influence of contextual constraint (strong versus moderate) on incidental vocabulary acquisition in reading, as eye movements of adult skilled readers were monitored. Surprise post-tests followed the reading session, and eye movement behaviour was directly connected to retention data. Longer and more frequent reading/rereading was associated with trials containing a novel target (rather than a known control), and unique patterns of connective rereading between constraint conditions were observed. For reading measures reflecting target word processing and connecting target with context, fixations were generally longer and more frequent for moderate constraint than for strong. The exception was in rereading of informative context, which was generally longer for strong constraint. More and longer fixations while connecting novel targets with informative context proved critical for novel word retention, significantly so for moderate constraint but not for strong, based on eye movement data associated with memory for novel word stimuli.     

Retrieval properties of negative vs. positive mental images and autobiographical memories in social anxiety: outcomes with a new measure

High (n = 41) and low (n = 39) socially anxious (SA) participants completed the Waterloo Images and Memories Interview (WIMI), a new assessment tool that measures the accessibility and properties of mental images and associated autobiographical memories that individuals may experience across both anxiety-provoking (negative) and non-anxiety-provoking (positive) social situations. Results indicated that both high and low SA individuals experience negative images and associated autobiographical memories in anxiety-provoking social situations, but the rates of endorsement of such images and memories among high SA participants were substantially lower than those reported in recent studies. Moreover, whereas low SA individuals were capable of accessing a relatively balanced array of both negative and positive self-representations that were rich in episodic detail, high SA individuals retrieved a higher, more unbalanced ratio of negative-to-positive images and memories, as well as impoverished positive images that were significantly degraded in episodic detail. Finally, negative images influenced the two groups differently, with high SA individuals experiencing more negative emotional and cognitive consequences associated with bringing such images to mind. These results are discussed in relation to theoretical models of learning and memory within the context of contemporary cognitive behavioral models of social anxiety.     

The influence of mother-child emotion regulation strategies on children's expression of anger and sadness

In a sample of 153 children from preschool through second grade, relations between the use of emotion regulation strategy and children's expression of anger and sadness were coded during an observational task in which children were intentionally disappointed in the presence of the mother. Multilevel modeling was used to examine strategy use and current and subsequent expressions of anger and sadness. Results indicate that mothers' use of attention refocusing and joint mother-child cognitive reframing lead to lower intensity of expressed anger and sadness. Younger children expressed more sadness than older children, and maternal attention refocusing was less successful among older children than younger ones. Implications of these results for assessing the socialization of emotion regulation in preschool and school-age children are discussed.     

An implicit basis for the retention benefits of random practice

The cognitive effort explanations of contextual interference (CI) and implicit motor learning represent a paradox in which cognitive involvement is seen to be advantageous or disadvantageous for learning. The authors aimed to resolve this paradox by measuring cognitive effort and working memory dependence during low and high CI practice on two Australian Rules Football tasks (kicking and handball). Measures of cognitive effort included: kicking and handball outcome performance during acquisition and during a test of retention, performance on a probe reaction time task during a sample of acquisition trials, and self-reported levels of cognitive effort. Measures of implicit and explicit learning included kicking and handball performance during a secondary task transfer, and self-report verbal protocols (number of verbal rules and hypotheses reported). The results suggest that high CI may cause an implicit mode of learning, perhaps due to the interference caused by task switching. However, these findings are restricted to the more complex of the 2 tasks (kicking).     

Semantic Processing in Children and Adults: Incongruity and the N400

Semantic processing in 10-year-old children and adults was examined using event related potentials (ERPs). The N400 component, an index of semantic processing, was studied in relation to sentences that ended with congruent, moderately incongruent, or strongly incongruent words. N400 amplitude in adults corresponded to levels of semantic incongruity with the greatest amplitude occurring to strongly incongruent sentences at all midline electrodes. In contrast, children’s N400s were greater for both moderately and strongly incongruent sentences but did not differ between these levels of incongruity. This finding suggests that semantic processing may differ in adults and children.     

Scale Imposition as Quantitative Alchemy: Studies on the Transitivity of Neuroticism Ratings

It is common practice in psychology to devise “measurement” procedures by imposing rating scales (e.g., Likert items) onto phenomena and treating the values they produce as quantities. The validity of these procedures goes untested. Validity checks are instead performed on sets of these measurement procedures (i.e., multi-item scales). We present results from three studies suggesting that people cannot be assumed to preserve transitivity when comparing themselves and others on NEO Neuroticism-domain trait items. As transitivity is one of the fundamental axioms of quantitative measurement, these studies challenge the validity of Neuroticism scales at the level of individual scale items.     

Three DIBELS Tasks vs. Three Informal Reading/Spelling Tasks: A Comparison of Predictive Validity

Within a developmental framework, this study compared the predictive validity of three DIBELS tasks (phoneme segmentation fluency [PSF], nonsense word fluency [NWF], and oral reading fluency [ORF]) with that of three alternative tasks drawn from the field of reading (phonemic spelling [phSPEL], word recognition-timed [WR-t], and graded passage reading [grPASS), an oral reading fluency measure). Two cohorts of students (n = 319) were assessed with the aforementioned tasks multiple times across a four-year period—middle of kindergarten through end of third grade. The results were clear and closely replicated in the two cohorts: (a) phSPEL (moderate) outperformed DIBELS PSF (weak to moderate) in predicting future orthographic-unit processing; (b) WR-t (very strong) outperformed DIBELS NWF (moderate) in predicting future oral reading fluency; and (c) DIBELS ORF and grPASS were equally good predictors (moderately strong) of future reading comprehension.