Restraint stress and corticotropin releasing hormone modulation of murine cutaneous POMC mRNA

The skin is a unique immunological defense barrier that protects the organism from occupational and environmental exposures and provides a model system in which to evaluate the interaction of the central nervous system with the peripheral immune response. In the studies presented here, we tested mild, acute restraint stress activation of the cutaneous corticotropin releasing hormone-pro-opiomelanocortin (CRH-POMC) axis. We verified that 2 h restraint stress increased the serum concentration of corticosterone and alpha-melanocyte stimulating hormone. We report for the first time that CRH upregulates POMC mRNA expression in mouse skin in vitro. We also demonstrated, by RT-PCR, that 2,4 di-nitrofluorobenzene (DNFB) upregulates cutaneous POMC mRNA expression, the production of which is suppressed by restraint stress. These data confirm the presence and functionality of two hormones of the hypothalamo-pituitary axis in the skin and suggest that activation of the central hypothalamo-pituitary-adrenal axis may over ride activation of the cutaneous CRH-POMC mechanism in the development of DNFB-stimulated allergic contact dermatitis.     

The relative importance of three domains of positive and negative social exchanges: a longitudinal model with comparable measures

Researchers have expressed considerable interest in the question of whether positive or negative social exchanges more strongly affect psychological health, but previous studies have been limited by using nonparallel measures of positive and negative social exchanges, by measuring negative affect only, and by relying largely on cross-sectional designs. The independent effects of positive and negative exchanges on both positive and negative affect were examined in a short-term longitudinal study of 277 older adults, using social exchange measures with parallel content and equivalent reliability and validity. In cross-sectional analyses, positive exchanges predicted positive affect, and negative exchanges predicted negative affect. In longitudinal analyses, however, negative exchanges predicted both positive and negative affect, whereas positive exchanges were unrelated to either outcome. The more potent and longer-lasting effects of negative exchanges have important implications for theory and interventions.     

Mommy and me: familiar names help launch babies into speech-stream segmentation

How do infants find the words in the tangle of speech that confronts them? The present study shows that by as early as 6 months of age, infants can already exploit highly familiar words-including, but not limited to, their own names-to segment and recognize adjoining, previously unfamiliar words from fluent speech. The head-turn preference procedure was used to familiarize babies with short passages in which a novel word was preceded by a familiar or a novel name. At test, babies recognized the word that followed the familiar name, but not the word that followed the novel name. This is the youngest age at which infants have been shown capable of segmenting fluent speech. Young infants have a powerful aid available to them for cracking the speech code. Their emerging familiarity with particular words, such as their own and other people's names, can provide initial anchors in the speech stream.     

Psychology in the public sector: addressing the psychological effects of combat in the U.S. Navy

The response of military psychology in times of war or other great public crises may presage the success of the profession in less perilous times. The ability of public-sector psychologists to provide assistance and improve the common welfare during conflict or turmoil is generally followed by an increased demand for psychological services. This likely reflects the success of the psychological response during those crises, and it underscores the fact that psychological consequences of war or disaster require both immediate clinical attention and long-term policy development. The U.S. Navy serves as a model for public-sector psychological service provision. A brief history of Navy psychology is provided, followed by an examination of how Navy psychologists are responding to the issues raised by the current conflict in the Middle East and the problems associated with stigma in the treatment of posttraumatic stress disorder.     

Processing of extrafoveal objects during multiple-object naming

In 3 experiments, the authors investigated the extent to which objects that are about to be named are processed prior to fixation. Participants named pairs or triplets of objects. One of the objects, initially seen extrafoveally (the interloper), was replaced by a different object (the target) during the saccade toward it. The interloper-target pairs were identical or unrelated objects or visually and conceptually unrelated objects with homophonous names (e.g., animal- baseball bat). The mean latencies and gaze durations for the targets were shorter in the identity and homophone conditions than in the unrelated condition. This was true when participants viewed a fixation mark until the interloper appeared and when they fixated on another object and prepared to name it while viewing the interloper. These results imply that objects that are about to be named may undergo far-reaching processing, including access to their names, prior to fixation.     

Aged rats are impaired on an attentional set-shifting task sensitive to medial frontal cortex damage in young rats

Normal aging is associated with disruption of neural systems that subserve different aspects of cognitive function, particularly in the hippocampus and frontal cortex. Abnormalities in hippocampal function have been well investigated in rodent models of aging, but studies of frontal cortex function in aged rodents are few. We tested young (4–5 mo old) and aged (27–28 mo old) male Long-Evans rats on an attentional set-shifting task modified slightly from previous publication. After training on two problems in which the reward was consistently associated with the same stimulus dimension, and a reversal of one problem, a new problem was presented in which the reward was consistently associated with the previously irrelevant stimulus dimension (extradimensional shift [EDS]). Aged rats as a group were significantly impaired on the EDS, although some individual aged rats performed as well as young rats on this phase. In addition, some aged rats were impaired on the reversal, although a group effect did not reach significance in this phase. Impairment in neither reversal nor EDS was associated with impairments in spatial learning in the Morris water maze. Young rats with neurotoxic lesions of medial frontal cortex are also selectively impaired on the EDS. These results indicate that normal aging in rats is associated with impaired medial frontal cortex function. Furthermore, age-related declines in frontal cortex function are independent of those in hippocampal function. These results provide a possible basis for correlating age-related changes in neurobiological markers in frontal cortex with cognitive decline.     

In focus. Life after BioethicsLine: a reply to Joyce Plaza

The recent closure and removal of BioethicsLine led many researchers to wonder where to turn for their research needs. Joyce Plaza wrote that the closure is a mistake. In this essay I maintain, contra Plaza, that due to its cross-disciplinary nature researchers can find bioethics literature in other databases. In developing the search strategy the researcher needs to consider what the problem is about. If the researcher has a philosophical approach in mind, a wise choice would be to use Philosopher's Index; a legal approach suggests using Academic Universe, Westlaw, Lexis or legal databases freely available through state and federal websites. Further, in so far as the National Library of Medicine is integrating citations in BioethicsLine into the NLM Gateway databases (PubMed and LOCATORplus) I point out suggestions on using the latter databases effectively. There is a wealth of information readily available and researchers have much to learn by trying the alternatives.     

The Roots of Love and Commitment in Childhood

Drawing from her clinical work with children and own childhood reflections, Dr. Lawrence underscores that the earliest sense of a true self is for the infant an experience of a self as worthy of love. This self-image becomes internalized as the infant looks into the mirror of the not too conflicted caregiver. She stresses that love which only can exist in relationship, is a social experience, does organize social experience, outstanding among these being commitments—commitments that bind a person to a course of action and connection. Dr. Lawrence interfaces psychoanalytic wisdom with spiritual references as she describes her work with children and families.     

Is early word-form processing stress-full? How natural variability supports recognition

In a series of studies, we examined how mothers naturally stress words across multiple mentions in speech to their infants and how this marking influences infants’ recognition of words in fluent speech. We first collected samples of mothers’ infant-directed speech using a technique that induced multiple repetitions of target words. Acoustic analyses revealed that mothers systematically alternated between emphatic and nonemphatic stress when talking to their infants. Using the headturn preference procedure, we then tested 7.5-month-old infants on their ability to detect familiarized bisyllabic words in fluent speech. Stress of target words (emphatic and nonemphatic) was systematically varied across familiarization and recognition phases of four experiments. Results indicated that, although infants generally prefer listening to words produced with emphatic stress, recognition was enhanced when the degree of emphatic stress at familiarization matched the degree of emphatic stress at recognition.