Acceptability of,and Information Needs Regarding,Next-Generation Sequencing in People Tested for Hereditary Cancer: A Qualitative Study

Next generation sequencing (NGS) for patients at risk of hereditary cancer syndromes can also identify non-cancer related mutations, as well as variants of unknown significance. This study aimed to determine what benefits and shortcomings patients perceive in relation to NGS, as well as their interest and information preferences in regards to such testing. Eligible patients had previously received inconclusive results from clinical mutation testing for cancer susceptibility. Semi-structured telephone interviews were subjected to qualitative analysis guided by the approach developed by Miles and Huberman. The majority of the 19 participants reported they would be interested in panel/genomic testing. Advantages identified included that it would enable better preparation and allow implementation of individualized preventative strategies, with few disadvantages mentioned. Almost all participants said they would want all results, not just those related to their previous diagnosis. Participants felt that a face-to-face discussion supplemented by an information booklet would be the best way to convey information and achieve informed consent. All participants wanted their information stored and reviewed in accordance with new developments. Although the findings indicate strong interest among these individuals, it seems that the consent process, and the interpretation and communication of results will be areas that will require revision to meet the needs of patients.     

Maqasid al-Shariah as a Complementary Framework to Conventional Bioethics

With the rapid advancements made in biotechnology, bioethical discourse has become increasingly important. Bioethics is a multidisciplinary and interdisciplinary field that goes beyond the realm of natural sciences, and has involved fields in the domain of the social sciences. One of the important areas in bioethical discourse is religion. In a country like Malaysia, where Muslims make up the majority of the population, Islam plays a crucial role in providing the essential guidelines on the permissibility and acceptability of biotechnological applications in various fields such as medicine, agriculture, and food processing. This article looks at the framework of a complementary model of bioethics derived from the perspective of Islam. The framework is based on ‘maqasid al-shariah’ (purposes or objectives of Islamic law) which aims to protect and preserve mankind’s faith, life, intellect, progeny, and property. It is proposed that ‘maqasid al-shariah’ be used as a pragmatic checklist that can be utilized in tackling bioethical issues and dilemmas.     

Freedom and Happiness in Nations: A Research Synthesis

Freedom is highly valued, but there are limits to the amount of freedom a society can allow its members. This begs the question of how much freedom is too much. The answers to that question differ across political cultures and are typically based on ideological argumentation. In this paper, we consider the compatibility of freedom and happiness in nations by taking stock of the research findings on that matter, gathered in the World Database of Happiness. We find that freedom and happiness are positively correlated in contemporary nations. The pattern of correlation differs somewhat across cultures and aspects of freedom. We found no pattern of declining happiness returns, which suggests that freedom has not passed its maximum in the freest countries.     

Family Structure Transitions: Prevalence and Physical Health Effects in Ethiopia,India, Peru,and Vietnam

Journal of Child and Family Studies - This study aimed to identify the prevalence and physical health consequences of family structure transitions among children in Ethiopia, India, Peru, and...     

Sexual desire,not hypersexuality,predicts self-regulation of sexual arousal

A person's ability to control their own sexual arousal is important both to reduce the risks associated with some sexual behaviours and to respond sexually with intimate partners. A lack of control over sexual urges is a proposed feature of “hypersexual disorder”, though some evidence suggests that sexual desire predicts the self-regulation of sexual arousal better than hypersexuality. In the current study, a sample (N = 116) of men and women recruited from community ads viewed a series of 20-second neutral and sexual films. Before each sexual film, participants were instructed to increase their sexual arousal, decrease their sexual arousal or respond as usual. Higher levels of desire for sex with a partner consistently predicted failures to downregulate sexual arousal. Hypersexuality was unrelated. These findings replicate Winters et al.'s study and extend their findings by including upregulation, women, a new measure of hypersexuality and a higher-trial design.     

Discrete emotions effect on consumer evaluation and behaviour: A contextual perspective and directions for future research

Emotions are the focal factor influencing consumer evaluation and behaviour. However, the present literature remains fragmented owing to conflicting findings on effects of emotions. Identifying moderator(s) of emotion's effect resolves these inconsistencies and helps comprehend when emotions are effective marketing tools. This study jointly reviews the literature on eight discrete emotions spanning over two decades (2000–2021), synthesizing and analysing the research on moderators attenuating, intensifying, or even reversing the effect of discrete emotions, documenting them at an individual and situational level. Based on that, an integrated contextually bounded emotion effect framework is advanced that resolves inconsistencies in literature and enables us to (1) draw instructive insights around discrete emotion dynamic effects owing to contextual variability, (2) identify similarities/differences within/across emotions and contextual factors (3) provide research-informed managerial implication and directions for future research.     

Increasing self-efficacy reduces visual intrusions to a trauma-film paradigm

Background and Objectives: It has been proposed that self-efficacy plays a critical role in the onset and maintenance of Posttraumatic Stress Disorder (PTSD). This study aimed to test if increasing perceptions of self-efficacy using a false feedback technique about coping abilities prior to a trauma-film paradigm lead to a reduction of visual intrusions over the course of 6 days.

Design and Methods: Healthy participants recruited from the community were randomized to a high self-efficacy (HSE, N?=?18), low self-efficacy (LSE, N?=?21), or neutral self-efficacy (NSE, N?=?23) conditions.

Results: Participants in the HSE condition reported higher levels of self-efficacy. In addition, individuals in the HSE conditions reported significantly fewer intrusions over 6 days. Unexpectedly, individuals in the LSE condition reported fewer intrusions on the final day of the study compared to those in the NSE condition. The LSE group was also the only group showing a significant linear decline in intrusion across the 6 days.

Discussion: These findings provide further support that perceptions of self-efficacy are modifiable and may contribute to clinically-relevant processes underlying PTSD. Future prospective research with individuals exposed to trauma will help to shed light on the potential role of self-efficacy to buffer the negative impacts of traumatic stress.     

Islamic Considerations on the Application of Patient’s Autonomy in End-of-Life Decision

Journal of Religion and Health - In end-of-life situation, the need for patient’s preference comes into the picture with the intention of guiding physicians in the direction of patient care....     

Rewards and Creativity: Past,Present, and Future

Research on the effects of rewards on creativity has resulted in hundreds of empirical studies and several reviews of the reward–creativity relationship (RCR). Most reviews are retrospective in nature. They have quantitatively summarised and integrated previous research findings, but have largely overlooked the need for a theoretical framework to guide future research. The current systematic review of this literature intends to bridge this gap, based on the findings of 329 papers and book chapters. Our review summarises the theoretical developments in reward–creativity (RC) research, and classifies the literature in three distinct phases, i.e. the emergence of the cognitive perspective; behavioural rebuttal, and convergence. The paper identifies three important gaps in the existing RC literature: (1) the moderating effects of individual, group, organisational, and national‐level factors; (2) the mediating role of cognitive and affective states; and (3) the lack of consideration of creativity as a multidimensional construct. Based on these gaps, the paper presents a four‐factor framework to guide future RC research. It identifies potential moderators and mediators of the RCR, and draws attention to creativity as a multidimensional construct.     

Is Grit Hurting You? The Dark Side of Psychological Resources in Goal Pursuit

This article presents a study of the curvilinear role of psychological resources during goal striving through an interactive model linking work goal progress to a valued resource. Specifically, we explore the nonlinear relationship of grit with work goal progress. Additionally, we test the moderating role of perceived organizational support (POS) for this relationship. We hypothesized that an employee’s goal pursuit is not merely contingent on the excessive availability of the selected resources but instead might be an outcome of interaction between personal resources and the environment. Our sample comprises 293 university professors working in the United States who completed questionnaires at two time points. The study findings confirm the curvilinear role of grit in predicting work goal progress. Furthermore, the moderating role of POS on the nonlinear relationship between grit and work goal progress is confirmed to be significant. We discuss the theoretical implications for industry concerning performance and self-regulation based on our findings.