The neurobiology of the stress-resistant brain

The 2010 Neurobiology of Stress Workshop brought together scientists from all over the world to share and discuss their results from studies examining the consequences of acute, repeated, and chronic stressor exposure on health and disease. Session IV entitled "The neurobiology of the stress-resistant brain" explored how we can intervene to promote stress resistance and stress resilience. Four scientists, who explore this topic from unique and convergent perspectives, presented their experimental results derived from studies in rat (Fleshner and Maier), non-human primates (Lyons), and human (Raskind). Summaries of each presentation, supporting publications, and overall take-home messages from the session are presented.     

The role of anxiety and perspective-taking strategy on affective empathic responses

Empathy is an important pro-social behaviour critical to a positive client–therapist relationship. Therapist anxiety has been linked to reduced ability to empathise and lower client satisfaction with therapy. However, the nature of the relationship between anxiety and empathy is currently unclear. The current study investigated the effect of experimentally-induced anxiety on empathic responses elicited during three different perspective-taking tasks. Perspective-taking was manipulated within-subjects with all participants (N = 52) completing imagine-self, imagine-other and objective conditions. A threat of shock manipulation was used to vary anxiety between-subjects. Participants in the threat of shock condition reported higher levels of anxiety during the experiment and lower levels of empathy-related distress for the targets than participants in the control condition. Perspective-taking was associated with higher levels of empathy-related distress and concern compared to the objective condition. The present results suggest that perspective-taking can to a large extent mitigate the influence of heightened anxiety on an individual’s ability to empathise.     

Effects of age on cross-modal emotion perception

Efficient navigation of our social world depends on the generation, interpretation, and combination of social signals within different sensory systems. However, the influence of healthy adult aging on multisensory integration of emotional stimuli remains poorly explored. This article comprises 2 studies that directly address issues of age differences on cross-modal emotional matching and explicit identification. The first study compared 25 younger adults (19-40 years) and 25 older adults (60-80 years) on their ability to match cross-modal congruent and incongruent emotional stimuli. The second study looked at performance of 20 younger (19-40) and 20 older adults (60-80) on explicit emotion identification when information was presented congruently in faces and voices or only in faces or in voices. In Study 1, older adults performed as well as younger adults on tasks in which congruent auditory and visual emotional information were presented concurrently, but there were age-related differences in matching incongruent cross-modal information. Results from Study 2 indicated that though older adults were impaired at identifying emotions from 1 modality (faces or voices alone), they benefited from congruent multisensory information as age differences were eliminated. The findings are discussed in relation to social, emotional, and cognitive changes with age.     

Social anxiety and anger regulation

Based on the assumption that social anxiety is associated with less assertive behaviour and that effective anger regulation is influenced by social anxiety, two studies were conducted to examine the relationship between social anxiety and anger regulation. In Study 1, questionnaires measuring social anxiety, assertiveness, and six habitual anger‐related responses were administered to 115 adults. Social anxiety had an independent effect on rumination and submission, whereas assertiveness was independently related to the use of humour and feedback. In Study 2 (N = 136 adults) self‐ and observer ratings of anger‐related behaviour were obtained after anger was experimentally induced. Social anxiety was related to self‐ratings of submission and rumination. However, independent observer ratings based on videotapes revealed no significant influence of social anxiety on anger‐related behaviour. Taken together, the results provide evidence that social anxiety is associated with the self‐perception of less assertive behaviour and the tendency to evaluate one's behaviour more negatively. These results are consistent with prior studies showing that socially anxious persons tend to underestimate their social performance relative to the ratings of independent observers. Copyright © 2004 John Wiley & Sons, Ltd.     

Verhaltenstherapie bei dissoziativen Störungen

Zusammenfassung Epidemiologische Daten bezüglich dissoziativer Auffälligkeiten werden vorgestellt. Diagnostizierbare dissoziative Störungen werden im Bereich des pathologischen Pols eines Kontinuums dissoziativer Phänomene eingeordnet. Ausgehend von der allen dissoziativen Störungen gemeinsamen Kernsymptomatik der strukturierten Separation mentaler Prozesse aus der ganzheitlichen Wahrnehmung wird ein universelles Ätiologiemodell dieser Erkrankungen dargestellt. Es basiert im Wesentlichen auf neueren Erkenntnissen der Neurobiologie und Gedächtnisforschung und bezieht sich auf die Traumatisierung als zentralem pathologenetischem Agens. Hiervon ausgehend, wird ein 2-phasiges Therapiemodell vorgestellt. Als Ziel wird ein Aussetzen bzw. eine Reduktion der dissoziativen Symptome über eine Integration der traumatischen Erfahrungen angestrebt. Die beschriebenen therapeutischen Vorgehensweisen sind grundsätzlich bei allen traumatisch bedingten dissoziativen Störungen anwendbar. Auf Konversionssymptome sowie die dissoziative Identitätsstörung wird als Sonderfälle separat eingegangen.Der Text basiert auf dem gleichnamigen Vortrag, den die Autorin am 24.10.2003 auf dem 5. Wissenschaftlichen Kongress der Deutschen Ärztlichen Gesellschaft für Verhaltenstherapie in Bad Pyrmont gehalten hat.     

Predictors of Risky and Precautionary Sexual Behaviors Among Single and Married White Women1

Risky and precautionary sexual behaviors were examined in a community sample of 260 single and married/cohabitating White women. Structural equation modeling was used to assess the ability of age, socioeconomic status (SES), marital status, religiosity, and 9 health belief constructs to predict risky sexual behavior with one's partner, using a barrier method of birth control, unintended pregnancies, and number of sexual partners in the past year. The pattern of results suggests that single White women appear to feel more vulnerable to HIV and STD infection and more likely to engage in risky sexual behavior than do married White women. The discussion focuses on the importance of sociocultural factors in understanding risk behaviors within the social context of relationship status, the complexity of the concept of risk reduction, and the need for going beyond the health belief model in order to develop different HIV prevention strategies for single and married White women.     

幼儿对条件许诺的理解

通过给4、5、6岁儿童呈现一系列图片,分别代表孩子、妈妈以及双方违反约定的不同情况,考察了幼儿对条件许诺形式的社会约定的理解。结果表明：幼儿对条件许诺的认知表现出明显的发展趋势,绝大多数幼儿都能指出孩子违反,随年龄增大能指出妈妈违反、双违反的人次百分比逐渐增多,其中4岁组没有人能指出妈妈违反,5岁组没有人能指出双违反;幼儿对条件许诺中不同角色违背的检测存在“角色效应”和“同侪违背优先检测效应”;多数幼儿还没有将条件许诺理解为双条件规则。     

Multiple causal pathways in attention-deficit/hyperactivity disorder – Do emerging executive and motivational deviations precede symptom development?

The multiple causal pathways model on the etiology of attention-deficit/hyperactivity disorder (ADHD) is well established. However, developmental implications of the model are not yet sufficiently analyzed. The model implies that critical neural and neuropsychological deviations from normative development precede secondarily developing ADHD symptoms. Cognitive, “cool” inhibitory control (CIC) and reward-related, “hot” functions (RRF) are regarded as neuropsychological basic deficits that indicate independent causal pathways. Both functions involve top-down control networks that undergo major normative developmental changes in the preschool period. We formalized the following assumptions in a path model: (a) CIC and RRF predict change in ADHD symptoms in the preschool period, (b) the reverse is not true, and (c) CIC and RRF independently contribute to this prediction. A community-based sample of 125 (71 boys) preschoolers was assessed at at age 4 and 5 years. At each assessment wave, CIC and RRF were measured by a battery of age-appropriate valid tasks. ADHD symptoms were measured by a clinical parent interview. Evaluation of model fit using manifest maximum likelihood parameter estimation clearly supported the hypothesized path model while controlling for gender of child and maternal education level. Thus, regarding the basic deficits of CIC and RRF, the results add evidence on the developmental implications of the multiple causal pathways model. Our findings point to the potential significance of these early emerging characteristics as indicators of risk and as targets for preventive interventions.     

Oxidative stress in university students during examinations

Mental stress in psychiatric disease and in daily life contributes to oxidative stress in the body. In this study we investigated a connection between possible psychological stress caused by university undergraduate examinations and oxidative stress experienced by our test subjects. Some parameters of oxidative stress (single strand breaks of DNA in lymphocytes, sensitivity to lipid oxidation and antioxidant status) were studied in medical students on the day of the examination (stress condition) and compared with the same parameters obtained from the same students during the term between two examination periods (non-stress condition). The results show that in the stress condition oxidative damage to DNA and sensitivity to lipid oxidation were significantly increased (p<0.05) when compared with the same parameters in "non-stress" conditions. A significant decrease in plasma antioxidant activity (p<0.05) in students that were under stress was observed. These results suggest that during university examinations students are under increased oxidative stress.     

A comparison of between- and within-subjects imitation designs

Two experimental methods, which have dominated the study of declarative memory in preverbal children with imitation tasks, namely the deferred imitation and elicited imitation paradigm, differ in the amount of physical contact with test stimuli afforded infants prior to a test for long-term recall. The current study assessed effects of pre- and post-demonstration contact with test stimuli on deferred imitation of novel, single-step unrelated actions with multiple objects by 8½- and 10½-month-old infants (N = 50). The rate of target action completion after a delay remained consistent at both ages across different conditions of prior contact with test stimuli. This study shows that a within-subjects baseline appraisal is valid within certain experimental parameters and offers a more economical alternative. The results show furthermore that different experimental designs utilized to assess deferred imitation are highly comparable for the first year despite differences in determining baseline.