Genetic Counseling Considerations in the Evaluation of Families for Lynch Syndrome��A Review

Lynch syndrome is the most common hereditary colorectal cancer syndrome and the most common cause of hereditary endometrial cancer. Identifying and evaluating families for Lynch syndrome is increasing in complexity due to the recognition that: family history-based clinical criteria lack sensitivity and specificity; genetic testing for Lynch syndrome continues to evolve as understanding of the molecular mechanisms underlying it evolves; and the Lynch syndrome phenotype encompasses multiple organ systems and demonstrates overlap with other hereditary cancer syndromes. This document is a summary of considerations when evaluating individuals and families for Lynch syndrome, including information on cancer risks, diagnostic criteria, tumor and genetic testing strategies, and the management of individuals with this condition.     

Correlates of self-worth and body size dissatisfaction among obese Latino youth

The current study examined self-worth and body size dissatisfaction, and their association with maternal acculturation among obese Latino youth enrolled in a community-based obesity intervention program. Upon entry to the program, a sample of 113 participants reported global self-worth comparable to general population norms, but lower athletic competence and perception of physical appearance. Interestingly, body size dissatisfaction was more prevalent among younger respondents. Youth body size dissatisfaction was associated with less acculturated mothers and higher maternal dissatisfaction with their child's body size. By contrast, although global self-worth was significantly related to body dissatisfaction, it was not influenced by mothers' acculturation or dissatisfaction with their own or their child's body size. Obesity intervention programs targeted to Latino youth need to address self-worth concerns among the youth as well as addressing maternal dissatisfaction with their children's body size.     

Assessing anti-fat bias in preschoolers: a comparison of a computer generated line-drawn figure array and photographic figure array

This study examined differences in preschoolers' ratings of anti-fat bias and identification of current body size depending on the realism of the figure array used: computer generated line-drawn or photographic. Children reported strong anti-fat bias with both arrays. However, less extreme bias was elicited with the photographic figure array. In addition, children were inaccurate reporters of their current body size when both figure arrays were used. However, children were consistent in their selection of figures that were thinner than their actual body size. Children's consistent selection of thinner figures as representative of their current body size may be an additional indicator of anti-fat bias. Overall, these results suggest that some of the anti-fat bias observed in preschoolers is attributable to less realistic figure arrays. Therefore, photographic figure arrays are proposed as a better measurement tool in the assessment of anti-fat bias in preschoolers.     

Animal Disenhancement and the Non-Identity Problem: A Response to Thompson

In his paper “The Opposite of Human Enhancement: Nanotechnology and the Blind Chicken problem” (Nanoethics 2:305–316, 2008) Paul Thompson argues that the possibility of “disenhancing” animals in order to improve animal welfare poses a philosophical conundrum. Although many people intuitively think such disenhancement would be morally impermissible, it’s difficult to find good arguments to support such intuitions. In this brief response to Thompson, I accept that there’s a conundrum here. But I argue that if we seriously consider whether creating beings can harm or benefit them, and introduce the non-identity problem to discussions of animal disehancement, the conundrum is even deeper than Thompson suggests.     

Aesthetic response to color combinations: preference, harmony, and similarity

Previous studies of preference for and harmony of color combinations have produced confusing results. For example, some claim that harmony increases with hue similarity, whereas others claim that it decreases. We argue that such confusions are resolved by distinguishing among three types of judgments about color pairs: (1) preference for the pair as a whole, (2) harmony of the pair as a whole, and (3) preference for its figural color when viewed against its colored background. Empirical support for this distinction shows that pair preference and harmony both increase as hue similarity increases, but preference relies more strongly on component color preference and lightness contrast. Although pairs with highly contrastive hues are generally judged to be neither preferable nor harmonious, figural color preference ratings increase as hue contrast with the background increases. The present results thus refine and clarify some of the best-known and most contentious claims of color theorists.