Endogenous estradiol is associated with verbal memory in nondemented older men

This study examined the relationship between endogenous hormones and cognitive function in nondemented, ethnically-diverse community-dwelling older men enrolled in the Einstein Aging Study (EAS). All eligible participants (185 men, mean age=81 years) received neuropsychological assessment (Free and Cued Selective Reminding Test (FCSRT), Logical Memory (LM), Trail Making Test B (TMTB), block design (BD)) and provided blood samples for hormonal assays (total estradiol, total testosterone, calculated free testosterone index). Linear regression analysis adjusted for age, education, body mass index, and cardiovascular comorbidities indicated that men with high levels of total estradiol demonstrated better FCSRT verbal memory performance (β=0.17, p<0.02) compared to men with lower levels of total estradiol. The results remained unchanged when the model was further adjusted for ethnicity. We did not detect an association between testosterone and cognitive performance. These findings indicate that high levels of total estradiol in older men are associated with better performance on a cue-based, controlled learning test of verbal memory that is a sensitive predictor of dementia.     

Risk for suicidal ideation and suicide attempts associated with co-occurring depression and conduct problems in early adolescence

This study investigates the early manifestation of co-occurring depression and conduct problems as a predictor of heightened risk for later suicidal ideation and behavior in a community sample of 521 adolescents. Self-reported symptoms of depression and conduct problems were evaluated in early 6th grade. Suicidal thoughts and behaviors were tracked through multiple assessments carried out over the middle school years. Compared to adolescents with depression symptoms only, conduct problem symptoms only, or low psychopathology, those with co-occurring depression and conduct problem symptoms had the highest risk for subsequent suicidal ideation, recurrent suicidal behaviors, and suicide attempts.     

Subtle priming of shared human experiences eliminates threat-induced negativity toward Arabs, immigrants, and peace-making

Many studies demonstrate that mortality salience can increase negativity toward outgroups but few have examined variables that mitigate this effect. The present research examined whether subtly priming people to think of human experiences shared by people from diverse cultures increases perceived similarity of members of different groups, which then reduces MS-induced negativity toward outgroups. In Study 1, exposure to pictures of people from diverse cultures engaged in common human activities non-significantly reversed the effect of MS on implicit anti-Arab prejudice. In Study 2, thinking about similarities between one's own favorite childhood memories and those of people from other countries eliminated MS-induced explicit negative attitudes toward immigrants. In Study 3, thinking about similarities between one's own painful childhood memories and those of people from other countries eliminated the MS-induced reduction in support for peace-making. Mediation analyses suggest the effects were driven by perceived similarity of people across cultures. These findings suggest that priming widely shared human experiences can attenuate MS-induced intergroup conflict.     

The Performance of Multivariate Methods for Two-Group Comparisons with Small Samples and Incomplete Data

Abstract

In intervention studies having multiple outcomes, researchers often use a series of univariate tests (e.g., ANOVAs) to assess group mean differences. Previous research found that this approach properly controls Type I error and generally provides greater power compared to MANOVA, especially under realistic effect size and correlation combinations. However, when group differences are assessed for a specific outcome, these procedures are strictly univariate and do not consider the outcome correlations, which may be problematic with missing outcome data. Linear mixed or multivariate multilevel models (MVMMs), implemented with maximum likelihood estimation, present an alternative analysis option where outcome correlations are taken into account when specific group mean differences are estimated. In this study, we use simulation methods to compare the performance of separate independent samples t tests estimated with ordinary least squares and analogous t tests from MVMMs to assess two-group mean differences with multiple outcomes under small sample and missingness conditions. Study results indicated that a MVMM implemented with restricted maximum likelihood estimation combined with the Kenward–Roger correction had the best performance. Therefore, for intervention studies with small N and normally distributed multivariate outcomes, the Kenward–Roger procedure is recommended over traditional methods and conventional MVMM analyses, particularly with incomplete data.