What Information Do Cancer Genetic Counselees Prioritize?

This study explored the informational needs of individuals attending genetic counseling for hereditary cancer, using a free-choice and a forced choice method. Prior to the consultation the informational needs of 334 counselees from Sweden and Norway were assessed by the QUOTE-gene (ca) questionnaire and by a study specific forced choice method, using Q-methodology. Questionnaire responses indicated that counselees' major concerns pertained to the need to be taken seriously, to be provided with sufficient risk estimation and medical/genetic information and to be involved in the decision making process. Furthermore, prior to counseling, counselees noted that the counselors' consideration and skillfulness were also extremely important. Analysis of the Q-sorting results revealed that counselees' needs could be assigned to one of five groups: the "need for facts; caring communication and medical information; information and support in communicating the genetic information to others; practical care and practical/medical information". Particularly noteworthy, counselees with varying backgrounds characteristics prioritized different needs. Cancer genetic counselees probably have different needs due to their medical and demographic background when attending genetic counseling. Addressing counselees' specific concerns more sufficiently and thereby increasing the overall effectiveness of the counseling session requires increased insight into individual needs, by for instance, utilizing screening methods such as QUOTE-gene (ca) prior to the counseling session.     

Consolidation and translation regulation

mRNA translation, or protein synthesis, is a major component of the transformation of the genetic code into any cellular activity. This complicated, multistep process is divided into three phases: initiation, elongation, and termination. Initiation is the step at which the ribosome is recruited to the mRNA, and is regarded as the major rate-limiting step in translation, while elongation consists of the elongation of the polypeptide chain; both steps are frequent targets for regulation, which is defined as a change in the rate of translation of an mRNA per unit time. In the normal brain, control of translation is a key mechanism for regulation of memory and synaptic plasticity consolidation, i.e., the off-line processing of acquired information. These regulation processes may differ between different brain structures or neuronal populations. Moreover, dysregulation of translation leads to pathological brain function such as memory impairment. Both normal and abnormal function of the translation machinery is believed to lead to translational up-regulation or down-regulation of a subset of mRNAs. However, the identification of these newly synthesized proteins and determination of the rates of protein synthesis or degradation taking place in different neuronal types and compartments at different time points in the brain demand new proteomic methods and system biology approaches. Here, we discuss in detail the relationship between translation regulation and memory or synaptic plasticity consolidation while focusing on a model of cortical-dependent taste learning task and hippocampal-dependent plasticity. In addition, we describe a novel systems biology perspective to better describe consolidation.     

Direction of threat attention bias predicts treatment outcome in anxious children receiving cognitive-behavioural therapy

BackgroundA bias to selectively direct attention to threat stimuli is a cognitive characteristic of anxiety disorders. Recent studies indicate that individual differences in pre-treatment threat attention bias predict treatment outcomes from cognitive-behavioural therapy (CBT) in anxious individuals. However, there have been inconsistent findings regarding whether attention bias towards threat predicts better or poorer treatment outcome.MethodThis longitudinal study examined treatment outcomes in 35 clinically-anxious children following a 10-week, group-based CBT program, as a function of whether children showed a pre-treatment attention bias towards or away from threat stimuli. The effect of CBT on attention bias was also assessed.ResultsBoth groups showed significant improvement after receiving CBT. However, anxious children with a pre-treatment attention bias towards threat showed greater reductions not only in anxiety symptom severity, but also in the likelihood of meeting diagnostic criteria for anxiety disorders at post-treatment assessment, in comparison with anxious children who showed a pre-treatment attention bias away from threat. Children who had a pre-treatment bias away from threat showed a reduction in this bias over the course of CBT.ConclusionsFindings suggest that pre-existing differences in the direction of attention towards versus away from threat could have important implications for the treatment of anxious children.     

From negative to positive and back again: Polarized affective and relational experience in borderline personality disorder

A core feature of borderline personality disorder (BPD) is the tendency to evaluate one's experience with extreme polarity (i.e., feeling all good or all bad; Beck, Freeman, & Davis, 2004; Kernberg, 1975; Linehan, 1993). In this investigation, we examined the polarity of within-person reports of experience in individuals with BPD and healthy adults over the course of a 21-day, experience-sampling diary. We applied multilevel modeling techniques (Rafaeli, Rogers, & Ravelle, 2007) to capture the within-person covariance of momentary reports of negative and positive features of experience, either affective or relational. Our data indicated significantly greater polarity in reports of affective and relational experiences in BPD that increased during heightened interpersonal stress. We also examined the association of affective and relational polarity to reports of impulsive behaviors (e.g., self-injury, substance use, etc.) and found evidence that increased polarity in reports of affective (in low-stress contexts) and relational experiences (in high-stress contexts) predicted increased rate of reports of impulsive behaviors. Together, these data present strong evidence for the role of polarized experiences in BPD, and have implications for the treatment of individuals with this disorder. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Human freezing in response to affective films

Human freezing has been objectively assessed using a passive picture viewing paradigm as an analog for threat. These results should be replicated for other stimuli in order to determine their stability and generalizability. Affective films are used frequently to elicit affective responses, but it is unknown whether they also elicit freezing-like defense responses. To test whether this is the case, 50 participants watched neutral, pleasant and unpleasant film fragments while standing on a stabilometric platform and wearing a polar band to assess heart rate. Freezing-like responses (indicated by overall reduced body sway and heart rate deceleration) were observed for the unpleasant film only. The unpleasant film also elicited early reduced body sway (1–2 s after stimulus onset). Heart rate and body sway were correlated during the unpleasant film only. The results suggest that ecologically valid stimuli like films are adequate stimuli in evoking defense responses. The results also underscore the importance of including time courses in human experimental research on defense reactions in order to delineate different stages in the defense response.     

Shyness as a risk factor for second language acquisition of immigrant preschoolers

The aim of this study was to examine whether shyness is a risk factor for second language acquisition in immigrant preschoolers. Results from studies on first language acquisition indicate that shy children show less favorable language development; however, it remains unclear how shyness affects second language acquisition. As second language skills are often acquired in interactions outside the family where shyness is more evident, we postulate that shyness has a strong negative effect on second language acquisition. This hypothesis was examined using standardized tests and parental ratings in a sample of 330 immigrant preschoolers cross-sectionally and with 130 immigrant preschoolers longitudinally. The analyses revealed lower second language competence as well as slower language development in shy immigrant children compared to their non-shy counterparts. The present study highlights that not only contextual but also personality factors need to be considered for a comprehensive understanding of second language acquisition in immigrant children.     

Influence of Attachment Style on Major Psychological Capacities to Lead

Addressing psychological literature's deficiency in research on the early development of leaders in everyday life (e.g., leaders in the workplace, leaders in social settings, leaders in organizational settings), this study assumed that central psychological capacities required for such leaders can be predicted and explained by J. Bowlby's (1969) Bowlby, J. 1969. Attachment and loss: Vol. 1. Attachment New York : Basic Books. [Google Scholar] attachment theory concerning developmental processes in infancy. The authors administered a series of questionnaires to 402 participants. The authors analyzed data by using structural equation modeling. Findings indicate a potential-to-lead construct that forms in infancy. The results fully supported the authors’ main arguments: that secure attachment style influences the potential to lead and that this capacity is essential for leadership as measured by leadership ranking.     

Physical activity and psychological benefits: A position statement from the international society of sport psychology

This study explores nonverbal behaviors in the form of gestures and touch during elite handball matches. Based on a coding scheme, 616 postshot periods following a goal, stemming from 18 matches, were analyzed. Results revealed that, on average, 2.77 nonverbal behaviors were displayed after scoring. Play-off matches resulted in a higher average of nonverbal behaviors than league matches. The more a team was leading by, the higher the overall number of nonverbal behaviors; meanwhile, the overall amount of nonverbal behaviors declined over the course of a match. The results pinpoint to the situation specificity of nonverbal behaviors during ongoing matches.     

Cross-sectional and longitudinal confirmatory factor models for the german test anxiety inventory: A construct validation

Construct validity of the German Test Anxiety Inventory (TAI-G) was tested in two respects. Firstly, the purported four-dimensional structure of the TAI-G (comprising subscales Emotionality, Worry, Interference, and Lack of Confidence) as well as relations of the test anxiety dimensions to self-efficacy were tested. Secondly, the trait conception of the TAI-G was tested within the framework of Latent State-Trait theory. The TAI-G was given to a student sample (N=302) on three occasions with a time interval of 2 weeks along with a study-specific self-efficacy scale on occasion 1. Dimensionality assumptions as well as relations with self-efficacy were tested using cross-sectional second-order confirmatory factor analysis. The trait conception was tested separately for TAI-G subscales by specifying longitudinal confirmatory factor models (Latent State-Trait models) and by calculating variance proportions of manifest variables (Latent State-Trait coefficients) referring to different sources of systematic variance (person, situation, and method) based on parameter estimates of the models. Results were supportive of both the purported four-dimensional structure and hypothesized relationships to self-efficacy (i.e., acceptable model fit) as well as of the trait conception of test anxiety (i.e., acceptable model fit and high proportion of variance due to person component). Implications for further validation studies were discussed.