Synthetic Biology and the Translational Imperative

Science and Engineering Ethics - Advances at the interface between the biological sciences and engineering are giving rise to emerging research fields such as synthetic biology. Harnessing the...     

The effects of adenosine receptor agonists and antagonists on morphine state-dependent memory of passive avoidance

Pretraining administration of morphine (5 mg/kg, intraperitonically) in a step-down passive avoidance task led to state-dependent learning with impaired retrieval on the test day that was dose-dependently restored by pretest administration of morphine (0.5, 1, 3, and 5 mg/kg). This restoration was reversible by pretest naloxone administration. Pretest administration of adenosine receptor antagonists theophylline or 8-phenyltheophylline (8-PT) did not alter morphine-induced amnesia. However, both the antagonists inhibited the restoration of memory by pretest morphine (5 mg/kg). Adenosine A(1) receptor agonists N(6)-cyclohexyladenosine (CHA) or N(6)-phenylisopropyladenosine (R-PIA) only at the higher doses used, and adenosine A(2) receptor agonist 5'-N-ethylcarboxaminoadenosine (NECA), at all doses used, decreased morphine-induced amnesia in a dose-dependent manner. Pretest administration of low doses of CHA, R-PIA, or NECA significantly showed additive effects with low dose pretest morphine (1 mg/kg) in restoring memory. The promnestic effects of high-dose CHA and R-PIA were inhibited by theophylline or 8-PT but not by naloxone. The additive effects of low-dose CHA or R-PIA and morphine were inhibited by theophylline, 8-PT, or a higher dose of naloxone. The promnestic effect of NECA and its additive effect with low-dose morphine were both inhibited by theophylline and naloxone but not by 8-PT. It is concluded that activation of the adenosinergic system, through both A(1) and A(2) receptors, can reverse morphine-induced amnesia and is involved in morphine state of memory.     

Behavioral Inhibition/Activation Systems and Self-Esteem with Depression: The Mediating Role of Social Anxiety

Journal of Rational-Emotive & Cognitive-Behavior Therapy - Many studies have focused on the role of self-esteem and behavioral inhibition/activation systems in social anxiety and depression....     

Emotional stimuli facilitate time perception in children with attention‐deficit/hyperactivity disorder

The aim of this study was to compare the effect of different emotional stimuli (neutral, positive, and negative) on time perception in children with attention‐deficit/hyperactivity disorder (ADHD) and normal children in dual‐task form. Five hundred and ninety‐nine students from primary schools were randomly selected. The Conner's Teacher Rating Scale (CTRS) questionnaire was completed by teachers. A total of 100 children with a score above the cut‐off point for the CTRS were further assessed using the Child Symptom Inventory‐4 (CSI‐4). A total of 34 children with ADHD and 31 controls completed an emotional time discrimination task in two blocks of 1000 and 2000 ms duration. Children were asked to compare three image groups: neutral with neutral, neutral with positive, and neutral with negative images. Children with ADHD had significantly better performance in the emotional time discrimination task across all conditions when compared with controls: On average, discrimination thresholds were approximately 35 ms shorter for the children with ADHD. Our results indicate that children with ADHD have higher sensitivity to time relative to controls in a situation in which they must distribute resources between temporal and emotional processing. On the basis of the interference effect and the working memory capacity hypothesis, this dividing of attention causes a decrease of time accuracy in normal children.     

Justifying political decisions through theological arguments

The relationship between religion and politics in Muslim contexts has been discussed from many different perspectives. One of these proceeds from the theory of religious politics, according to which political thoughts and decisions are justified and legitimated with the support of theological explanations. A central premise is that religion is able to provide a moral sanction for political actions and decisions. This article discusses the relationship between religion and politics in a Shiite context in pre-modern and early modern times, based on the theory of religious politics. The central point is that the Shiite scholars, during the Safavid era (1501–1736), based their secular viewpoints on interpretations of the Quran, the hadiths, and the 12 Imamite Shiite sources, especially the specific ideas about the hidden imam, to legitimate their own collaboration with the Safavid kings. According to this theory, the religious politics occur within an ideological context such as a nation-state and specific historical circumstances. The religious legitimizations of political actions are usually intertwined with local and historical identities. As such the religious ideologies reflect not a return to tradition per se, but rather an ideological reconstruction of tradition for a new context. The ultimate question is which came first? Did the theological interpretations precede secular and political decisions, or was it the other way around? The theory of religious politics arrives at the conclusion that the theological explanations are employed to legitimate traditions of political thought and secular decisions and not the reverse.     

TECHNOLOGY AND MUSLIMS: A FIELD STUDY OF IRANIAN SCHOLARS

Muslim scholars have had different approaches toward modern technologies. Defining the situation in various Islamic countries is dependent on knowing the approaches adopted by their scholars. These approaches create norms which can shed light on the reasons for the success and failure of access to technology and its transference. The present article sets out to analyze the views of the Qom seminary scholars in Iran about the development of modern technologies within the framework of the development sociology using the qualitative methodology of grounded theory. To this end, such techniques as conducting interviews and investigating documents have been used to gather the data. The authors find four paradigm models regarding modern technologies among the Qom seminary scholars. These models are classified into two general categories: optimistic and pessimistic. In the end, an “appropriate technology” approach is introduced as an approach singled out by the researchers.     

Can Video Self-Modeling Improve Affected Limb Reach and Grasp Ability in Stroke Patients?

The authors examined whether feedforward video self-modeling (FF VSM) would improve control over the affected limb, movement self-confidence, movement self-consciousness, and well-being in 18 stroke survivors. Participants completed a cup transport task and 2 questionnaires related to psychological processes pre- and postintervention. Pretest video footage of the unaffected limb performing the task was edited to create a best-of or mirror-reversed training DVD, creating the illusion that patients were performing proficiently with the affected limb. The training yielded significant improvements for the forward movement of the affected limb compared to the unaffected limb. Significant improvements were also seen in movement self-confidence, movement self-consciousness, and well-being. FF VSM appears to be a viable way to improve motor ability in populations with movement disorders.