Dissociable contributions of the left and right posterior medial orbitofrontal cortex in motivational control of goal-directed behavior

Several findings from both human neuroimaging and nonhuman primate studies suggest that the posterior medial orbitofrontal cortex (OFC) may be critical for the motivational control of goal-directed behavior. The present study was conducted to clarify the role of the left and right posterior medial OFC in that function by examining the effects of focal unilateral lesions to this region on the performance on an incentive working memory task. The study covered patients who had undergone surgery for an ACoA aneurysm and normal control subjects (C). The patients were subdivided into three groups: those with resection of the left (LGR+) or right (RGR+) posterior part of the gyrus rectus, and without such a resection (GR−). Participants performed a 2-back working memory task under three motivational conditions (penalty, reward, and no-incentive). The C group performed worse in the penalty condition and better in the reward condition as compared to the no-incentive condition. Similar results were obtained for the GR− group. Performance of the LGR+ group did not depend on incentive manipulations, whereas the RGR+ group performed better in both the penalty and reward conditions than in the no-incentive condition. The results show that the posterior medial OFC is involved in the motivational modulation of working memory performance. Our findings also suggest that the left posterior medial OFC plays a crucial role in this function, whereas the right posterior medial OFC is particularly involved in the processing of the punishing aspect of salient events and it probably mediates in guiding behavior on the basis of negative outcomes of action.     

Sequential congruency effects: disentangling priming and conflict adaptation

Responding to the color of a word is slower and less accurate if the word refers to a different color (incongruent condition) than if it refers to the same color (congruent condition). This phenomenon, known as the Stroop effect, is modulated by sequential effects: it is bigger when the current trial is preceded by a congruent condition than by an incongruent one in the previous trial. Whether this phenomenon is due to priming mechanisms or to cognitive control is still debated. To disentangle the contribution of priming with respect to conflict adaptation mechanisms in determining sequential effects, two experiments were designed here with a four-alternative forced choice (4-AFC) Stroop task: in the first one only trials with complete alternations of features were used, while in the second experiment all possible types of repetitions were presented. Both response times (RTs) and errors were evaluated. Conflict adaptation effects on RTs were limited to congruent trials and were exclusively due to priming: they disappeared in the priming-free experiment and, in the second experiment, they occurred in sequences with feature repetitions but not in complete alternation sequences. Error results, instead, support the presence of conflict adaptation effects in incongruent trials. In priming-free sequences (Experiment 1 and complete alternation sequences of Experiment 2) with incongruent previous trials there was no error Stroop effect, while this effect was significant with congruent previous trials. These results indicate that cognitive control may modulate performance above and beyond priming effects.     

Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: indications for central and peripheral mechanisms

A promising target for memory improvement is phosphodiesterase type 5 (PDE5), which selectively hydrolyzes cyclic guanosine monophosphate (cGMP). In rodents, PDE5 inhibitors (PDE5-Is) have been shown to improve memory performance in many behavioral paradigms. However, it is questioned whether the positive effects in animal studies result from PDE5 inhibition in the central nervous system or the periphery. Therefore, we studied the effects of PDE5 inhibition on memory and determined whether compound penetration of the blood-brain barrier (BBB) is required for this activity. Two selective PDE5-Is, vardenafil and UK-343,664, were tested in the object recognition task (ORT) in both a MK-801- and scopolamine-induced memory deficit model, and a time-delay model without pharmacological intervention. Compounds were dosed 30 min before the learning trial of the task. To determine if the PDE5-Is crossed the BBB, their concentrations were determined in plasma and brain tissue collected 30 min after oral administration. Vardenafil improved object recognition memory in all three variants of the ORT. UK-343,664 was ineffective at either preventing MK-801-induced memory disruption or time-dependent memory decay. However, UK-343,664 attenuated the memory impairment of scopolamine. Vardenafil crossed the BBB whereas UK-343,664 did not. Further, co-administration of UK-343,664 and scopolamine did not alter the brain partitioning of either molecule. This suggests that the positive effect of UK-343,664 on scopolamine-induced memory decay might arise from peripheral PDE5 inhibition. The results herein suggest that there may be multiple mechanisms that mediate the efficacy of PDE5 inhibition to improve memory performance in tasks such as the ORT and that these involve PDE5 located both within and outside of the brain. To further elucidate the underlying mechanisms, the cellular and subcellular localization of PDE5 needs to be determined.     

End state copying by humans (Homo sapiens): implications for a comparative perspective on cumulative culture

It has been proposed that the uniqueness of human cumulative culture may be attributable to humans' greater orientation toward copying the process of behavior (imitation), as compared with the products (emulation), resulting in particularly high fidelity transmission. Following from previous work indicating that adult human participants can exhibit cumulative learning on the basis of product copying alone, we now investigate whether such learning involves high fidelity transmission. Eighty adult human (Homo sapiens) participants were presented with a task previously shown to elicit cumulative learning under experimental conditions, which involved building a tower from spaghetti and modeling clay. Each participant was shown two completed towers, ostensibly built by previous participants, but actually built to prespecified designs by the experimenter. This end state information was provided either in the form of photographs, or the presence of actual towers. High fidelity matching to these end states was apparent in both demonstration conditions, even for a design that was demonstrably suboptimal with regard to the goal of the task (maximizing tower height). We conclude that, although high fidelity transmission is likely to be implicated in cumulative culture, action copying is not always necessary for this to occur. Furthermore, since chimpanzees apparently copy behavioral processes and well as products, and also transmit behavior with high fidelity, the stark absence of unequivocal examples of cumulative culture in nonhumans may be attributable to factors other than imitative ability.     

Motivational Interviewing Promotes Adherence and Improves Wellbeing in Pre-Dialysis Patients with Advanced Chronic Kidney Disease

Low rates of adherence to medical treatments and adverse emotional states are a widespread problem in advanced chronic kidney disease (ACKD). Motivational interviewing using the stages of change model is an effective combination in promoting behavior modifications. The objective of the present study was to determine the effectiveness of an individual, pre-dialysis intervention program (monthly sessions of 90 min over a 6-month period) in terms of adherence, emotional state and health-related quality of life (HRQL). Forty-two patients were evaluated for adherence, depression, anxiety and HRQL with standardized self-report questionnaires. Biochemical markers were also registered. The results show that after the intervention, patients reported significantly higher levels of adherence, lower depression and anxiety levels, and better HRQL (i.e., general health and emotional role domains). Biochemical parameters were controlled significantly better after the intervention, except for iPTH. These findings highlight the potential benefit of applying individual psycho-educational intervention programs based on motivational interviewing and using the stages of change model to promote adherence and wellbeing in ACKD patients.     

Enduring as Lived Experience: Exploring the Essence of Spiritual Resilience for Women in Late Life

The purpose of this study was to explore spirituality and its relationship to resilience for women in late life. Over thirty interviews with six women aged 80 and older provide a dataset allowing for the phenomenological investigation of spiritual resilience. Themes emerged illustrating the components of spiritual resilience. The components of spiritual resilience are having divine support, maintaining purpose, and expressing gratitude. These factors are essential to the women’s resilience and act as mechanisms that promote high levels of subjective well-being and an overall good quality of life. Essentially, participants articulate how their experiences of enduring hardships are informed by spiritual resilience.     

The Effects of a Summer Camp Program in China on Children's Knowledge,Attitudes, and Behaviors Toward Animals: A Model for Conservation Education

ABSTRACT

This summative evaluation, conducted in Chengdu, Sichuan Province, China, studied whether participation in a conservation education camp positively changed 8–12-year-old children's (a) knowledge of how to protect animals, (b) care about animals, (c) propensity for environmental and wildlife stewardship, and (d) compassionate behavior toward animals and nature. Influenced by conservation psychology, social learning theory, empathy and moral development, constructivism, and conservation biology, 5-day overnight camps were conducted at 2 zoological institutions. Activities were designed to help children form bonds with animals and care enough to positively change their behavior toward animals and nature. Mixed methods, using pre- and postvisit surveys, researcher field notes, vignettes, student journals, an end of camp questionnaire, and a camper behavior ethogram, revealed significant increases in knowledge, care, and propensity for action, and an additional theme, empathy. This study identified effective strategies to promote positive behavior toward animals, empathy, and conservation behavior.     

Female Shamanism and the Mapuche Transformation into Christian Chilean Farmers

This article examines the emergence of a new form of shamanism among the Mapuche of Chile during their first decades under the dominion of the Chilean state. Specifically, it links the emergence of a female shamanism with the policies implemented by the Chilean government and the Catholic Church to integrate the Mapuche into the Chilean society as Christian farmers. The material of this paper is based on historical material from 1881 to 1930.     

Via Kundalini: Psychosomatic excursions in transpersonal psychology

Abstract

A model of psychosomatic mysticism (PM) is proposed that reintroduces the body into transpersonal psychology. The argument for PM develops links between transpersonal psychology and neuroimmunology and includes scientific notions of the mind as embodied not just in the brain but more widely throughout the body, as well as the comparative analyses of perspectives on the body in various spiritual traditions. PM is used to examine how transpersonal psychology can integrate the body, thus meeting the goals of the clinician, the standards of the researcher, and the emerging needs of psychosomatic medicine. The core principles of PM are explicated, such as: 1) decentralized consciousness, 2) structural phenomenological correlations between the psyche and the body, 3) in‐depth understanding of energy as intentionality, and 4) the possibility of actualizing cosmic awareness in the individual psyche. Examples of the clinical use of psychospiritual practices of PM show practical applications of these principles. It is concluded that the studies of the embodied consciousness and subtle energies through PM can help to develop both transpersonal theory and applications.     

Editorial: Psychosocial Aspects of AIDS

This article comprises two parts.

In the first part, some general issues related to research training are discussed, including the “Scientist-Practitioner Model,” training for basic and applied research, differences between the USA and Europe at various levels of training, and types or areas of research students should be trained for.

In the second part, seven specific objectives of research training are discussed. These objective are (a) learning to write a review of the research literature, (b) learning to critically evaluate a journal article, (c) learning to plan and carry out a specific health psychology research study, (d) learning to communicate, (e) learning to enhance co-operation of professionals in the field, (f) learning to raise funds, (g) learning to respect ethical issues.