Healthy Children As Subjects in Pharmaceutical Research

Recruitment of healthy children for drugresearch has emerged due in part to several newAmerican laws and policies that have led to asurge in pharmaceutical research involvingchildren-subjects. In this paper, I review theethical and scientific issues and the argumentsin favor and against this new practice.     

Experimental stimulation by burst-firing weak magnetic fields over the right temporal lobe may facilitate apprehension in women.

Intermittent bursts of weak magnetic fields whose patterns simulate normal amygdaloidal-hippocampal activity were generated by computer over the right or left temporal regions of men and women during partial sensory deprivation. As predicted, women but not men reported greater apprehension during right-hemispheric but not left-hemispheric stimulation. Intrusions of right-hemispheric processes have been hypothesized to affect self-esteem adversely. These results also support the role of the right parahippocampal region in the production of panic attacks.     

Background sound pressure fluctuations (5 DB) from overhead ventilation systems increase subjective fatigue of university students during three-hour lectures.

During each of four successive sessions (once per week), 21 university students attended 3-hr. lectures. During alternative weeks the fans of the room's ventilation system were either on or off. When operating, they generated an average sound pressure that varied continuously between 60 and 65 dB. The dominant frequency of this 5-dB amplitude modulation of sound pressure was within the electroencephalographic range (5 Hz to 25 Hz). At the end of each hour of the lecture for each session each student estimated on 7-point summated rating scales fatigue (none to maximum) and concentration (poor to excellent). As a group, the students reported more fatigue during lectures when the fans were operating relative to lectures when the fans were not operating. This environmental effect explained about 30% of the variance in fatigue ratings and may be sufficient to affect adversely the attention of students within these settings.     

Handwriting process and product characteristics of children diagnosed with developmental coordination disorder

Deficits in handwriting performance limit the school participation of children with developmental coordination disorder (DCD). The aim of this study was to compare the handwriting process and product characteristics of children with DCD to those of typically developing (TD) children in order to determine the best means of differentiation between the groups. Participants were 40 children, from 7 to 10 years old. The experimental group consisted of 20 children who met the criteria of DCD, and the control group consisted of 20 age- and gender-matched controls. The children were asked to perform three graded writing tasks on an electronic tablet, which was part of a computerized handwriting evaluation system (ComPET), in order to obtain measures of their handwriting process. The children's handwriting product was then evaluated by the Hebrew Handwriting Evaluation (HHE). Results showed significant differences between the groups for the handwriting process measures (on-paper and in-air time, mean pressure) and for the handwriting product characteristics (global legibility, number of letters erased or overwritten, spatial arrangement, and number of letters written in the first minute). The discriminant analysis yielded a high significant discrimination (80-90%), with the 'number of letters erased or overwritten' variable as the most differentiating variable (-.67). We concluded that an evaluation of both handwriting process and product characteristics among children with DCD provides a more comprehensive picture of their deficits. Using this method may enable practitioners to focus on children's main deficits and to tailor intervention methods so as to prevent academic underachievement and its consequences on their emotional well-being.     

Long term course of chronic posttraumatic stress disorder in traffic accident victims: a three-year prospective follow-up study

The purpose of the present study was to gather prospective longitudinal data on the long-term course and outcome of chronic posttraumatic stress disorder (PTSD). The target population for this study was 74 injured traffic accident victims who had been previously followed-up for one year after the trauma. Nineteen of the original 24 PTSD subjects (79%) and 39 of the original 50 Non-PTSD subjects (78%) were available for this study, which took place during the fourth year after the accident. Our results show that 10 (53%) of the 19 patients with PTSD at one-year still suffered from PTSD after another two-year follow-up interval, while 9 recovered from PTSD during this follow-up period. Only 2 of the 39 without PTSD at one year developed delayed onset PTSD. The best predictor of recovery from chronic PTSD was the initial level of posttraumatic reaction immediately after the accident. These results demonstrate that spontaneous recovery from PTSD can occur even among patients who are currently considered chronic. Severity of initial reaction to the trauma appears to be a major risk factor for non-remitting chronic PTSD.     

Overparenting and Young Adults’ Interpersonal Sensitivity: Cultural and Parental Gender-Related Diversity

The first goal of this study was to investigate whether levels of overparenting behavior (anticipatory problem-solving, advice/affect management, tangible assistance, and low levels of child self-direction) differ depending on the context (Arab-Israeli vs. Jewish-Israeli; mothers vs. fathers). Second, we considered whether the association between overparenting and young adults’ interpersonal sensitivity depends on those contexts. Questionnaires were collected from 165 triads (mothers, fathers, and young adults), of which 89 were Jewish-Israeli and 76 Arab-Israeli. Parents reported on their overparenting behaviors and young adults reported on their interpersonal sensitivity. Results indicated that all four dimensions of overparenting behaviors were more prominent in Arab-Israeli culture than in Jewish-Israeli culture, while advice/affect management was lower for mothers than for fathers and fathers provided more child self-direction than mothers. In addition, higher levels of anticipatory problem-solving were significantly associated with higher levels of young adult interpersonal sensitivity, independent of parental gender or cultural background, supporting the general negative association between anticipatory problem-solving and interpersonal sensitivity.     

Gender matters when sports engagement and self-efficacy interact with academic achievement

Social Psychology of Education - This study examines, through the lens of gender, whether engagement in sports, self-efficacy and grade level affect academic achievements of adolescents. The study...     

Easily perceived, easily remembered? Perceptual interference produces a double dissociation between metamemory and memory performance

A recent candidate for explaining metamemory judgments is the perceptual fluency hypothesis, which proposes that easily perceived items are predicted to be remembered better, regardless of actual memory performance (Rhodes & Castel Journal of Experimental Psychology: General 137:615–625, 2008). In two experiments, we used the perceptual interference manipulation to test this hypothesis. In Experiment 1, participants were presented with intact and backward-masked words during encoding, followed by a metamemory prediction (a list-wide judgment of learning, JOL) and then a free recall test. Participants predicted that intact words would be better recalled, despite better actual memory for words in the perceptual interference condition, yielding a crossed double dissociation between predicted and actual memory performance. In Experiment 2, JOLs were made after each study word. Item-by-item JOLs were likewise higher for intact than for backward-masked words, despite similar actual memory performance for both types of words. The results are consistent with the perceptual fluency hypothesis of metamemory and are discussed in terms of experience-based and theory-based metamemory judgments.