移植免疫中微嵌合现象给我们的思考

随着移植免疫学研究的不断深入发展,诱导免疫耐受克服移植排斥反应已成为器官移植的主要研究目标。Starzl提出“双向移植排斥理论”并阐述临床使用免疫抑制药物下移植排斥反应的特点,突破了原有单向移植排斥理论的框架。“双向移植排斥理论”及理论内存在的问题给予我们众多有益的思考,在移植免疫学研究中,只有坚持用系统原则动态的看待事物间的联系与矛盾,进行科学实践,才能获得正确的理论,从而进一步推动移植免疫学的发展。     

Perceived Parenting Styles and Cultural Influences in Adolescent’s Anxiety: A Cross-Cultural Comparison

A growing body of literature links particular parenting practices with negative child outcomes including greater anxiety symptoms among western societies. However, the effects of cultural differences on such linkages have not been adequately addressed in the anxiety literature. This study therefore aimed to examine the relationship between perceived parenting style and anxiety among Malay, Chinese, Indian, Arab and European/American (Caucasian) origins adolescents and the possible cultural group influences on this relationship was studied. Using multiple cluster sampling, a total of 227 students (122 boys and 105 girls) aged 13–18 years was selected. They completed questionnaires measuring parental rearing behaviors (EMBU-C) and anxiety symptoms scale (SCAS). Results indicated that in comparison to the European/American; Asian samples reported greater anxiety symptoms on all subscales of anxiety. Parental rejection, anxious rearing and control/over protection were correlated to higher anxiety independent of cultural group but these associations were stronger for Caucasians. Parenting styles as predictor of anxiety were found to be cross culturally different. Although European/American adolescents rated their parents as least over controlling, it was significant predictor of anxiety. This study provides evidence for the notion that relationship between parenting factors and anxiety were different across cultural contexts.     

直觉和分析在不同信息获取与呈现方式下对多特征目标判断质量的影响

采用多特征目标判断任务,考察了不同信息获取方式与信息呈现方式条件下,直觉和分析思维模式对判断质量的影响。结果发现：（1）在多特征目标判断任务中,直觉思维比分析思维更有效;（2）直觉型决策者运用直觉思维的判断质量比感觉型决策者更高;（3）归类组块的信息呈现方式能够有效提升决策者运用直觉思维的判断质量;（4）思维模式、信息获取方式与信息呈现方式对多特征目标的判断质量存在三阶交互作用,归类组块的信息呈现方式使直觉型决策者运用直觉思维的判断质量最高,而运用分析思维的判断质量低于感觉型决策者;归类组块排列信息时,直觉型决策者运用分析思维的判断质量低于信息随机排列时的水平。     

急性应激损害对威胁刺激的注意解除

急性应激会增强个体对威胁刺激的注意偏向,但急性应激是增强了对威胁刺激的注意定向还是损害了对威胁刺激的注意解除还不清楚。本研究采用社会评估冷压任务和点探测任务,结合事件相关电位技术,考察急性应激对威胁刺激注意偏向影响的认知机制。在进行社会评估冷压任务后,应激组个体的状态焦虑和皮质醇浓度显著升高。在注意偏向中,应激组对威胁刺激的注意解除比控制组更慢,应激组和控制组在对威胁刺激的注意定向上无显著差异。ERP结果上,威胁刺激诱发应激组比控制组产生了更负的SPCN,在N2pc上没有显著差异。应激组和控制组皮质醇增量的差异和N2pc、SPCN的组间差异均有显著正相关。这些结果说明,急性应激增强对威胁刺激的注意偏向是因为其损害个体对威胁刺激的注意解除,这可能是因为急性应激损害了与注意解除相关的额-顶网络的功能所致。     

Is the psychological refractory period effect for ideomotor compatible tasks eliminated by speed-stress instructions?

It has been argued that the psychological refractory period (PRP) effect is eliminated with two ideomotor compatible tasks when instructions stress fast and simultaneous responding. Three experiments were conducted to test this hypothesis. In all experiments, Task 1 required spatially compatible manual responses (left or right) to the direction of an arrow, and Task 2 required saying the name of the auditory letter A or B. In Experiments 1 and 3, the manual responses were keypresses made with the left and right hands, whereas in Experiment 2 they were left-right toggle-switch movements made with the dominant hand. Instructions that stressed response speed reduced reaction time and increased error rate compared to standard instructions to respond fast and accurately, but did not eliminate the PRP effect on Task 2 reaction time. These results imply that, even when response speed is emphasized, ideomotor compatible tasks do not bypass response selection.     

Psychological Flexibility at Work and Employees' Proactive Work Behaviour: Cross‐Level Moderating Role of Leader Need for Structure

How to promote employees to be proactive behaviourally is a significant issue in the literature because it would benefit organisations in several ways. Drawing on the acceptance and commitment model, we proposed a new antecedent, psychological flexibility that might contribute to employees' proactive work behaviour. Furthermore, we investigated how the contextual role of supervisor need for structure exhibits a cross‐level moderating effect on the relationship between employee psychological flexibility at work and proactive work behaviour based on interactionism. Data from 241 full‐time employees and their corresponding 45 managers indicated that employee psychological flexibility was positively associated with proactive work behaviour. More importantly, the supervisor need for structure played a moderating role, suggesting that employees would demonstrate greater proactive work behaviour especially when the supervisors have a high need for structure. Implications for psychological flexibility, proactivity, and person‐situation interactional research are discussed.     

Conceptualizing Culturally Infused Engagement and Its Measurement for Ethnic Minority and Immigrant Children and Families

Despite the central role culture plays in racial and ethnic disparities in mental health among ethnic minority and immigrant children and families, existing measures of engagement in mental health services have failed to integrate culturally specific factors that shape these families’ engagement with mental health services. To illustrate this gap, the authors systematically review 119 existing instruments that measure the multi-dimensional and developmental process of engagement for ethnic minority and immigrant children and families. The review is anchored in a new integrated conceptualization of engagement, the culturally infused engagement model. The review assesses culturally relevant cognitive, attitudinal, and behavioral mechanisms of engagement from the stages of problem recognition and help seeking to treatment participation that can help illuminate the gaps. Existing measures examined four central domains pertinent to the process of engagement for ethnic minority and immigrant children and families: (a) expressions of mental distress and illness, (b) causal explanations of mental distress and illness, (c) beliefs about mental distress and illness, and (d) beliefs and experiences of seeking help. The findings highlight the variety of tools that are used to measure behavioral and attitudinal dimensions of engagement, showing the limitations of their application for ethnic minority and immigrant children and families. The review proposes directions for promising research methodologies to help intervention scientists and clinicians improve engagement and service delivery and reduce disparities among ethnic minority and immigrant children and families at large, and recommends practical applications for training, program planning, and policymaking.     

The Relationship between Online Game Experience and Multitasking Ability in a Virtual Environment

Online game playing has become popular entertainment, yet its relationship with individuals' multitasking ability was inconsistent. Types of online game genre so far have not been compared and may be associated with multitasking abilities. This study proposed to explore the relationships between types of online game playing and multitasking ability, using Edinburgh Virtual Errands Test (EVET). One hundred and sixteen participants playing different online game genres, including multiplayer online battle arena (MOBA), other online game playing, and no‐online game playing were compared. Each participant was required to fill in Chen's Internet Addiction Scale and the Internet Usage Questionnaire and perform EVET and working memory tests. The results showed a positive correlation between multitasking ability and working memory. In addition, a positive association was found between MOBA‐type gaming and multitasking abilities measured by EVET. In conclusion, MOBA‐type gaming compared with other game playing is associated with better multitasking abilities in a virtual environment.Copyright © 2017 John Wiley & Sons, Ltd.     

义符促进类别归纳推理的ERP证据

为了明确义符对归纳推理影响,本研究使用有义符和无义符汉字为材料,使用ERP技术考查义符对不同层级类别概念归纳推理的影响。行为结果显示,有义符条件下反应速度更快,肯定判断率更高。脑电指标上,P3阶段义符主效应显著,有义符条件下P3波幅更大;N1、N400和P600阶段义符与层级交互作用显著,组内简单效应分析显示,层级主效应仅在无义符条件下显著;组间简单效应分析显示,义符主效在N400和P600阶段仅在下-上推理条件下显著,无义符条件下,下-上推理引发更大的N400和P600波幅。这些结果表明,义符促进了归纳推理过程,这种促进主要表现在对下-上推理的促进。