The Early Neuropsychological and Behavioral Characteristics of Frontotemporal Dementia

Frontotemporal lobar degeneration (FTLD) represent a constellation of disorders that may be overlooked or misdiagnosed, despite being fairly common presenile neurodegenerative diseases. Although the cognitive disorder can be difficult to document, particularly early in the dementia course, neuropsychological evaluation can assist in the diagnosis. Neuropsychologists are in an excellent position to draw from related disciplines like personality theory and social psychology to better assess the types of changes that characterize the prodromal and early phases of the disease. This review summarizes the current state of the field in the diagnosis of FTLD and discusses the emerging role of neuropsychology in elucidating the brain organization of complex processes including empathy, behavioral control and inhibition, reward systems, appetitive behaviors, emotional regulation, and goal-orientation. As this review underscores, frontotemporal dementia remains a powerful model for studying brain–behavior relationships.     

Prefrontal Cortex,Emotion, and Approach/Withdrawal Motivation

This article provides a selective review of the literature and current theories regarding the role of prefrontal cortex, along with some other critical brain regions, in emotion and motivation. Seemingly contradictory findings have often appeared in this literature. Research attempting to resolve these contradictions has been the basis of new areas of growth and has led to more sophisticated understandings of emotional and motivational processes as well as neural networks associated with these processes. Progress has, in part, depended on methodological advances that allow for increased resolution in brain imaging. A number of issues are currently in play, among them the role of prefrontal cortex in emotional or motivational processes. This debate fosters research that will likely lead to further refinement of conceptualizations of emotion, motivation, and the neural processes associated with them.     

Retention of high tactile acuity throughout the life span in blindness

Previous studies of tactile acuity on the fingertip, using passive touch, have demonstrated an age-related decline in spatial resolution for both sighted and blind subjects. We have reexamined this age dependence with two newly designed tactile-acuity charts that require active exploration of the test symbols. One chart used dot patterns similar to braille, and the other used embossed Landolt rings. Groups of blind braille readers and sighted subjects ranging from 12 to 85 years old were tested in two experiments. We replicated previous findings for sighted subjects by showing an age-related decrease in tactile acuity by nearly 1% per year. Surprisingly, the blind subjects retained high acuity into old age, showing no age-related decline. For the blind subjects, tactile acuity did not correlate with braille reading speed, the amount of daily reading, or the age at which braille was learned. We conclude that when measured with active touch, blind subjects retain high tactile acuity into old age, unlike their aging sighted peers. We propose that blind people's use of active touch in daily activities, not specifically braille reading, results in preservation of tactile acuity across the life span.     

Memories and anticipations control responding by rats (<Emphasis Type="Italic">Rattus norvegicus</Emphasis>) in a Pavlovian procedure

In Experiment 1 each rat received two different fixed series of three trials each. The unconditioned stimulus occurred on Trial 1 of one series and on Trial 3 of the other series, all other trials being nonreinforced. Previous Pavlovian investigations have shown that rats can remember the immediately prior reward outcome and anticipate the immediately subsequent reward outcome. Experiment 1 demonstrated that rats could remember and anticipate even more remote reward outcomes. In Experiment 2 two groups received a series of two nonrewarded trials followed by a rewarded trial. It was demonstrated that a change in the conditioned stimulus (CS) from Trial 2 to Trial 3, which occurred in one group, produced weaker responding than in the other group that did not experience such CS change. On the basis of these findings it was suggested that the rats organized the trials of a series into a unit or chunk. This was concluded for two reasons. First, remembering and anticipating remote reward outcomes strongly suggests that responding is being controlled by events extending beyond the current trial. Secondly, the experimental manipulations employed in the Pavlovian situation here are similar to those used in prior human learning and animal instrumental learning investigations concerned with chunking. Thus, it would appear that chunking is a ubiquitous phenomenon appearing in human serial learning (e.g., Bower and Winzenz 1969; Crowder 1976), in animal instrumental learning (e.g., Capaldi 1992; Hulse and Dorsky 1977; Terrace 1987), and now in Pavlovian learning.     

精神分裂症对情绪的面部表情加工及其神经机制

综述了近年来关于精神分裂症对情绪面部表情加工损伤的研究,讨论了这种损伤的性质,以及对这种损伤性质的解释,比如它属于一般性还是特异性的损伤,与临床症状以及认知特征之间的关系等。比较分析表明,精神分裂症情绪面部表情知觉损伤,可能兼有面部信息加工障碍和情绪信息知觉困难的特性。另外,介绍了国外关于针对精神分裂症面部表情再认和识别的康复训练研究以及近年来利用事件相关电位（ERPs）和功能磁共振成像（fMRI）等认知神经科学技术进行的神经生理机制研究     

Response grouping in the psychological refractory period (PRP) paradigm: models and contamination effects

Response grouping is a ubiquitous phenomenon in psychological refractory period (PRP) tasks, yet it hampers the analysis of dual-task performance. To account for response grouping, we developed several extended versions of the standard bottleneck model, each of which incorporates a possible grouping mechanism into this model. Computer simulations were used to assess how the predictions of the standard model would change with each grouping mechanism. One set of simulations investigated the basic effects of grouping on the means and intercorrelation of the reaction times in the two tasks, as well as the percentage of trials with short interresponse times (IRTs). A second set of simulations examined whether response grouping would invalidate the use of PRP paradigms for localizing experimental effects. Finally, we investigated whether the post-hoc elimination of trials with short IRTs removes the contaminating effects of response grouping.     

Precuing benefits for color and location in a visual search task

Selection in multiple-item displays has been shown to benefit immensely from advance knowledge of target location (e.g., Henderson, 1991), leading to the suggestion that location is completely dominant in visual selective attention (e.g., Tsal & Lavie, 1993). Recently, direct selection by color has been reported in displays in which location does not vary (Vierck & Miller, 2005). The present experiment investigated the possibility of independent selection by color in a task with multiple-item displays and location precues in order to see whether color is also used for selection even when target location does vary and supposedly dominant location precues can be used. Precues provided independent information about the location and color of a target, and each type of precue could be either valid or invalid. The precues were followed by brief displays of six letters in six different colors, and participants had to discriminate the case of a prespecified target letter (e.g., R vs. r). Performance was much better when location cues were valid than when they were invalid, confirming the large advantage associated with valid advance location information. Performance was also better with valid advance color information, however, both when location cues were valid and when they were invalid. But these color benefits were dependent on the closeness of the colored letter to the cued location. Our results thus suggest that selection by color in a multiple-item display, where location and color information are independent from each other and equalized, is mediated by location information.     

父母对儿童青少年媒介使用的积极干预

积极干预是指父母在孩子使用媒介前后或者使用过程中, 通过解释和讨论等互动形式对媒介内容、使用方式等提供指导。随着电子媒介在家庭中的普及, 父母如何正确引导儿童青少年的媒介使用行为受到了研究者的关注。父母对媒介使用进行积极干预对儿童青少年认知发展、社会性发展等诸多方面产生了积极作用, 例如提高儿童对媒介内容的批判能力, 有效减少暴力内容可能产生的消极影响等。影响积极干预行为的因素可归纳为两大类：家庭因素和儿童个体因素。未来研究可从完善测量方法, 探究父母干预行为与儿童青少年媒介使用之间相互影响的机制, 建构影响因素模型, 提高积极干预的有效性等角度进行深入探索。     

线索呈现位置对概率类别学习的影响

当前概率类别学习中主要存在多系统和单系统两种观点之争, 而持不同观点的研究者在其实验中分别采用了不同的线索位置呈现方式, 因此本研究采用经典的天气预测任务通过操纵线索位置的呈现方式来进一步探讨其对概率类别学习的影响。本研究包括2个实验：实验1考察所有线索位置固定和随机对概率类别学习系统的影响; 实验2通过单线索模式下线索位置固定考察概率类别学习的策略。结果发现, 当所有线索的呈现位置固定时, 概率类别学习是外显学习; 而当所有线索的呈现位置随机时, 概率类别学习是内隐学习; 而当只在线索单独出现时固定其位置, 概率类别学习仍是内隐学习。结果表明, 线索位置的不同呈现方式会影响概率类别学习中外显和内隐学习系统的竞争, 研究支持了多系统观点, 且概率类别学习的主要策略可能是多线索策略而不是单模式策略。