The impact of mediodorsal thalamic lesions on olfactory attention and flavor perception

Olfactory attention may be important in generating odor-induced tastes - an arguably universal form of synesthesia - by ensuring that the taste concurrent is captured by the nose and olfaction, not by the mouth and gustation (oral-capture). To examine the role of olfactory attention in generating odor-induced tastes and oral capture we tested a small sample (n = 4) of participants with likely impairments in olfactory attention - individuals with mediodorsal thalamic nucleus (MDNT) lesions. These participants were compared to two sets of controls on tests of olfactory attention, oral capture, odor and flavor perception, and control tasks. MDNT participants demonstrated impaired olfactory attention and enhanced oral capture. Greater oral capture was associated with greater olfactory attentional impairment. These findings imply that olfactory attention may be important in attributing odor-induced tastes to the olfactory modality. However, unlike for visual binding and for the neurodevelopmental synesthesias, where attention may be necessary to demonstrate both phenomena, olfactory attention deficits did not impair flavor binding or the experience of odor-induced tastes.     

Dave Eggers's a heartbreaking work of staggering genius: memoir as a "pain-relief device"

Dave Eggers's memoir is an important addition to the tradition of autobiography in America, and offers significant contributions to our understanding of creativity, sublimation, and the psychology of the memoir-writing process. A Heartbreaking Work of Staggering Genius is really two books--an autobiographical narrative about unbearable suffering, and a book of psychoanalytic commentary on the challenges of writing a memoir about catastrophic loss and trauma. The main narrative suggests the psychological resilience it takes to contain unbearable suffering. The metanarrative renders transparent the mind of someone who is both remembering his losses and constantly reflecting upon the process of writing about them. Eggers's identification with authorship, rather than bereavement or traumatization, may have played an important role in containing his affect and his sense of self when the heartbreaking events were originally unfolding. But a price is paid when a son uses his art to construct a new identity as an author--unconscious conflicts, primitive affect, anxieties about failing, as well as guilt about succeeding--consequences often missed by readers. Heartbreaking is a palimpsest, a story about story-telling superimposed on tales of death and survival, but its messages will be missed unless all its parts are preserved when being read or studied.     

Voice pitch influences perceptions of sexual infidelity

Sexual infidelity can be costly to members of both the extra-pair and the paired couple. Thus, detecting infidelity risk is potentially adaptive if it aids in avoiding cuckoldry or loss of parental and relationship investment. Among men, testosterone is inversely related to voice pitch, relationship and offspring investment, and is positively related to the pursuit of short-term relationships, including extra-pair sex. Among women, estrogen is positively related to voice pitch, attractiveness, and the likelihood of extra-pair involvement. Although prior work has demonstrated a positive relationship between men?s testosterone levels and infidelity, this study is the first to investigate attributions of infidelity as a function of sexual dimorphism in male and female voices. We found that men attributed high infidelity risk to feminized women?s voices, but not significantly more often than did women. Women attributed high infidelity risk to masculinized men?s voices at significantly higher rates than did men. These data suggest that voice pitch is used as an indicator of sexual strategy in addition to underlying mate value. The aforementioned attributions may be adaptive if they prevent cuckoldry and/or loss of parental and relationship investment via avoidance of partners who may be more likely to be unfaithful.     

Stakeholders’ Opinions on the Implementation of Pediatric Whole Exome Sequencing: Implications for Informed Consent

Advances in whole genome and whole exome sequencing (WGS/WES) technologies have led to increased availability in clinical settings. Currently, there are few guidelines relating to the process and content of informed consent for WGS/WES, nor to which results should be returned to families. To address this gap, we conducted focus groups to assess the views of professionals, parents, and adolescents for the future implementation of WES. The discussions assessed understanding of the risks and benefits of WES, preferences for the informed consent discussion, process for return of results, and the decision-making role of the pediatric patient. Professional focus group participants included bioethicists, physicians, laboratory directors, and genetic counselors. Parent focus groups included individuals with children who could be offered sequencing due to a potential genetic cause of the child’s condition. On-line discussion groups were conducted with adolescents aged 13–17 who had a possible genetic disorder. We identified discrepancies between professionals and patient groups regarding the process and content of informed consent, preference for return of results, and the role of the child in decision-making. Professional groups were concerned with the uncertainty regarding professional obligations, changing interpretation in genomic medicine, and practical concerns of returning results over time. Parent and adolescent groups focused on patient choice and personal utility of sequencing results. Each group expressed different views on the role of the child in decision-making and return of results. These discrepancies represent potential barriers to informed consent and a challenge for genetic counselors regarding the involvement of pediatric patients in decision-making and return of results discussions.     

Threshold estimation in two-alternative forced-choice (2AFC) tasks: the Spearman-Kärber method

The Spearman-K?rber method can be used to estimate the threshold value or difference limen in two-alternative forced-choice tasks. This method yields a simple estimator for the difference limen and its standard error, so that both can be calculated with a pocket calculator. In contrast to previous estimators, the present approach does not require any assumptions about the shape of the true underlying psychometric function. The performance of this new nonparametric estimator is compared with the standard technique of probit analysis. The Spearman-K?rber method appears to be a valuable addition to the toolbox of psychophysical methods, because it is most accurate for estimating the mean (i.e., absolute and difference thresholds) and dispersion of the psychometric function, although it is not optimal for estimating percentile-based parameters of this function.     

Recent advances in operant conditioning technology: a versatile and affordable computerized touchscreen system.

We report the construction of a new operant chamber that incorporates modern computer, touchscreen, and display technologies. An LCD display was housed in the front wall of a lightweight Plexiglas chamber. An Apple eMac computer was used to present visual stimuli on the monitor and to control other chamber events. Responses to the stimuli were recorded using a transparent resistive-type touchscreen that overlaid the monitor. The resulting system is simple and inexpensive to construct but powerful and flexible enough to explore a broad range of issues in animal learning and behavior.     

Three constructions of transference in Freud, 1895-1915

Three distinct constructions of transference which have related though differentiable histories can be identified in Freud's writings. The postulation of discrete meta-psychological, clinical, and universal constructions was completed by 1915, although many significant revisions within those constructions were made thereafter. Most significant is the distinction drawn between the clinical and universal constructions which (while both are founded on the metapsychological construction) facilitates recognition of cultural critical uses of transference as distinct from the clinical transference phenomena and as applicable far beyond the confines of psychopathology.