Engineering Values Into Genetic Engineering: A Proposed Analytic Framework for Scientific Social Responsibility

Recent experiments have been used to “edit” genomes of various plant, animal and other species, including humans, with unprecedented precision. Furthermore, editing the Cas9 endonuclease gene with a gene encoding the desired guide RNA into an organism, adjacent to an altered gene, could create a “gene drive” that could spread a trait through an entire population of organisms. These experiments represent advances along a spectrum of technological abilities that genetic engineers have been working on since the advent of recombinant DNA techniques. The scientific and bioethics communities have built substantial literatures about the ethical and policy implications of genetic engineering, especially in the age of bioterrorism. However, recent CRISPr/Cas experiments have triggered a rehashing of previous policy discussions, suggesting that the scientific community requires guidance on how to think about social responsibility. We propose a framework to enable analysis of social responsibility, using two examples of genetic engineering experiments.     

The Children's Apperception Test: Puzzle and Regular Form

To see whether more apperceptive responses could be elicited, the Children's Apperception Test (CAT) was used in a way which required the child to become motorically involved with the pictures. It was found that more children give significantly more apperceptive responses to a puzzle form of the CAT than to the regular form. Therefore, it was felt that the puzzle form was a more valuable instrument. It was suggested that any projective technique for very young children should be designed so that the response from the child results from his being actively involved in the situation.     

The MMPI–2 Restructured Clinical (RC) Scales and Redundancy: Response to Tellegen,Ben-Porath,and Sellbom

In this article, we examine 5 criticisms of Tellegen, Ben-Porath, and Sellbom (2009/this issue) about our study demonstrating the redundant relationships of the Restructured Clinical (RC) scales with extant MMPI–2 scales. We discuss differences in univariate versus multivariate comparisons of the RC scales and our “proxy” scales using their data. We show that (a) both the RC and extant proxy scales identified in our analyses account for most of the variance in the Clinical scales; (b) the proxy scales are redundant with the RC scales; (c) the proxy scales matched the 6 RC scales in accounting for variance in the Clinical scales exactly in three cases, differed by ≤.02 in 2 cases, and reached a maximum of .11 in one case; (d) the item overlap between RC1 and HEA is not at issue but rather their correlation with Scale 1; and (e) the evidence for the construct validity of the RC scales is weak using findings on the incremental validity of RC4 as illustrative.     

The Duty to Support Nationalistic Policies

We demonstrate that citizens perceive a duty to support policies that benefit their nation, even when they themselves judge that the consequences of the policies will be worse on the whole, taking outsiders into account. In terms of actions, subjects think they would do their perceived duty rather than violate it for the sake of better consequences. The discrepancy between duty and judged consequences does not seem to result from self‐interest alone. When asked for reasons, many subjects felt an obligation to help their fellow citizens before others, and they also thought that they owed something to their nation, in return for what it did for them. The obligation to help fellow citizens was the strongest predictor of perceived duty. In an experiment with Israeli and Palestinian students, group membership affected both perceived overall consequences and duty, but the effect of group on perceived consequences did not account for the effect on perceived duty. Copyright © 2011 John Wiley & Sons, Ltd.     

Specificity of MMPI cluster types to chronic illness

Abstract

Cluster analysis derived MMPI profile types were compared for three distinct illness populations: chronic low back pain (CLBP), mixed headache (HA), and cardiac disease (CD). Results replicated previous findings in the chronic pain and cardiac literatures. Differences between diagnostic groups and genders were found for the prevalence of the derived MMPI profile types. Results indicated that, in males, the two chronic pain groups had similar profile types and similar relative frequencies of these types, but both differed from the CD sample. The chronic pain groups tended to have a greater number of patients with pathological and distressed MMPI profile types and a lesser representation in the subclinical profile type compared to the CD sample. Similar findings were obtained for females, though the CLBP group tended to have a higher frequency of highly distressed, pathological profiles than either the HA or CD groups. Results suggested that the MMPI may be a measure of response to illness rather than reflecting predisposing personality types for any given illness and that the higher frequency of highly distressed profiles in the chronic pain samples reflects the increased suffering of those populations compared to other illnesses.     

Paradoxical effects of presentation modality on false memory.

Two experiments are reported in which the effects of presentation modality on false memory in recall and recognition are studied. False recall and recognition of critical targets are lower for non-presented items related to a study list when that study list is presented visually than when presented auditorily. This pattern of low levels of false memory for critical targets holds even when participants read the visually presented study items aloud. These results suggest that recollection of visual detail plays a role in the prevention of false memory. However, both the hit rates (true memory) and the false-alarm rates to weakly related distractors (non-critical targets) were higher for visual presentation than for auditory presentation, suggesting that more than one mechanism may underlie false recognition.     

At the Edge of Eternity's Shadows: Scaling the Fractal Continuum from Lower into Higher Space

In this paper, I elaborate the hyperspatial implications of the fractal-scaling scheme that I introduced previously. Four case examples where out-of-body experiencers reported heightened and amplified visual capacities are correlated with this explanatory model. Three of these cases are identified as including an additional hyperspace signifier, the reported capacity to see through solid and opaque physical obstructions. One of these cases included yet another hyperspace signifier, the reported capacity to pass through such obstructions. Additional evidence supportive of this thesis is drawn from the literature on ecstatic experience, including out-of-body, near-death, and other varieties of mystical or visionary experience, and from that on psychedelic experience. Yet other hyperspace signifiers reported by ecstatic voyagers are also considered, including sensations of seeing outward spherically in 360 degrees and of seeing on all sides of three-dimensional solids simultaneously.     

Immediate serial recall of mixed-modality lists

Seven experiments are reported in which subjects were tested for immediate serial recall of mixed-modality lists. On mixed auditory-visual lists, there was an advantage for auditory items at all serial positions. This was due to both a facilitation of auditory items and an inhibition of visual items on mixed lists, as compared with single-modality lists. When presented on a list containing items read silently, recall of items that were silently mouthed by the subject demonstrated patterns similar to those found with auditory items. When presented on a list containing items read aloud, recall of mouthed items showed patterns similar to those found with silently read items. The auditory advantage on mixed lists was found even when the list items were acoustically similar or identical and was not reduced by midlist auditory suffixes. The results suggest that modality differences in recall of mixed-modality lists are based on information different from that responsible for modality differences in recall of single-modality lists.