Polyaminergic agents modulate contextual fear extinction in rats

Polyamines, such as spermidine and spermine, have been reported to improve memory retention through the activation of N-methyl-d-aspartate receptors (NMDAr). However whether polyamine agonists and antagonists alter extinction remains unclear. In the current study, we investigated whether spermidine and polyamine antagonists that selectively block the NR2B subunit at the NMDAr alter the extinction of contextual conditioned fear in male Wistar rats. The bilateral intra-hippocampal administration of exogenous spermidine (2 nmol/site) immediately after, but not 6 h after extinction training, facilitated the extinction of fear conditioning. The injection of the NMDAr antagonists arcaine (0.2 nmol/site), ifenprodil (20 nmol/site) and traxoprodil (0.2 nmol/site), disrupted fear extinction and, at doses that had no effect per se, reversed the facilitatory effect of spermidine on fear extinction. These results suggest that exogenous and endogenous polyamines facilitate the extinction of contextual conditioned fear through activation of NR2B subunit-containing NMDAr in the hippocampus. Since extinction-based exposure therapy is widely used as treatment for a number of anxiety-related disorders, including phobias and post-traumatic stress, the currently reported facilitation of extinction by polyaminergic agents suggest these compounds as putative candidates for drug development.     

Concurrent Validity of the Personality Assessment Inventory Borderline Scales in Patients Seeking Dialectical Behavior Therapy

Drawing on a large, nationally representative sample of young adults (the National Longitudinal Study of Adolescent Health; N = 15,701; M age = 29.10), we evaluated the psychometric properties of the Mini-IPIP, a 20-item inventory designed to concisely assess the 5 factors of personality. The results suggest that the Mini-IPIP has a 5-factor structure; most of the scales have acceptable reliability; all the scales have partial or full metric invariance; and the scales exhibit some degree of criterion validity. However, the absence of scalar invariance for many of the scales suggests caution when comparing personality scores among groups defined by sex or race and ethnicity. We offer practical considerations for researchers interested in using this inventory with this sample, and also suggestions for modification of the Mini-IPIP.     

Developmental Progression of Clock Face Drawing in Children

The clock drawing test has been routinely administered by many neuropsychologists as part of their testing battery with the adult population. Our study investigated the development of clock face drawing in normal children ages 6 to 12 years. Conceptualization of time and construction of the clock face were assessed by an adapted scoring system developed as part of the investigation. As a group, the results indicated an upward progression with regard to the concept of time through age 8 and clock construction through age 12. Results further demonstrated that number reversals were more frequent among left-handers but were no longer evident by age 7 regardless of handedness. It also was determined that left visuospatial neglect specific to the upper quadrant was relatively common in 6- and 7-year olds but not evidenced by age 8. Given the pattern of the findings, it is likely that the neglect was secondary to poor planning and not a visuo-spatial deficit. In general, development of clock face drawing most closely paralleled that of frontal lobe maturation. Implications of these findings and the usefulness of clock face drawing with the pediatric population are presented.     

The effect of information distribution on collaborative inhibition

Two experiments examined collaborative memory for information that was studied by all group members (shared items) and information that was studied by only a subset of group members (unshared items). In both experiments significant collaborative inhibition (reduced output of the collaborative groups relative to the pooled output of individuals) was obtained for both shared and unshared information. In Experiment 1 the magnitude of collaborative inhibition was larger for unshared items than for shared items, possibly because unshared items were less likely to be acknowledged and thus incorporated into the groups’ recall. In Experiment 2 the magnitude of collaborative inhibition for shared and unshared information was equivalent once all participants were provided with the category name associated with the shared and unshared items. The results of the experiments are discussed in relation to the retrieval strategy disruption hypothesis of collaborative inhibition and the role of social process variables, such as acknowledgement, in influencing collaborative inhibition across situations involving memory of shared and unshared information.     

Development and validation of the Fat Talk Questionnaire

Fat talk refers to negative body-related conversations between girls or young women. This research aimed to use qualitative data from young women to guide development of a quantitative fat talk measure. In Study 1, a preliminary 62-item questionnaire was developed and administered to 200 female participants. Item analysis resulted in the elimination of items, yielding a final questionnaire with 14 items. Principal components analysis of this questionnaire indicated a single factor. In Study 2, 95 female participants completed the newly developed Fat Talk Questionnaire and theoretically related (e.g., body image) and unrelated (e.g., social desirability) constructs. Additionally, 49 male participants completed the questionnaire to examine known groups validity. In Study 3, 54 participants completed the Fat Talk Questionnaire on two occasions to assess temporal stability. The results showed that the Fat Talk Questionnaire is reliable and valid. The Fat Talk Questionnaire may have important utility in future research.     

The Northwestern-UCLA youth emotion project: Associations of cognitive vulnerabilities, neuroticism and gender with past diagnoses of emotional disorders in adolescents

Neuroticism has been hypothesized to be a non-specific risk factor for both anxiety and unipolar mood disorders whereas some cognitive and personality-cognitive vulnerabilities have been hypothesized to be more specific to depression. Using a retrospective design with a sample of 575 high school juniors, we tested three competing models of the associations among these variables. Both neuroticism and the cognitive and personality-cognitive vulnerabilities had significant zero-order associations with rates of past diagnoses of both anxiety and unipolar mood disorders. Neuroticism had significant unique associations with past anxiety disorders and comorbid anxiety and unipolar mood disorders whereas the other vulnerabilities did not. In addition, gender interacted with neuroticism but not with the other vulnerabilities in associating with past diagnoses of mood disorders, showing that neuroticism is more highly associated with past unipolar mood diagnoses in males than in females. Finally, the cognitive and personality-cognitive vulnerabilities overlapped with substantial portions of the variance that neuroticism shared with diagnoses. These results suggest that, at least for retrospective associations with past anxiety and unipolar mood disorders, the cognitive and other personality-cognitive vulnerabilities are non-specific facets of neuroticism.     

The Effects of Implicit Theories on Exercise Motivation

This study investigated whether type of implicit theory about athletic coordination would influence motivation to persist at a novel exercise task in the face of difficulty. Fifty college students were told that we were testing a new type of exercise and were given one of two theories about the nature of athletic coordination. Some participants were told that athletic coordination was mostly learned (incremental condition), while others were told that athletic coordination was genetically determined (entity condition). Participants initially experienced success and then difficulty while following videos containing the new exercise. Consistent with predictions, results showed that participants given an incremental theory of athletic coordination reported greater motivation and self-efficacy and less negative affect in the face of difficulty than those given an entity theory. Implications of these findings are discussed.     

Cluster A Personality Disorders: Schizotypal,Schizoid and Paranoid Personality Disorders in Childhood and Adolescence

Cluster A personality disorders (PD), including schizotypal personality disorder (SPD), paranoid personality disorder (PPD), and schizoid PD, are marked by odd and eccentric behaviors, and are grouped together because of common patterns in symptomatology as well as shared genetic and environmental risk factors. The DSM-IV-TR describes personality disorders as representing stable and enduring patterns of maladaptive traits, and much of what is understood about Cluster A personality disorders in particular stems from research with adult populations. Less in known about these disorders in children and adolescents, and controversy remains regarding diagnosis of personality disorders in general in youth. The current paper reviews the available research on Cluster A personality disorders in childhood and adolescence; specifically, we discuss differentiating between the three disorders and distinguishing them from other syndromes, measuring Cluster A disorders in youth, and the nature and course of these disorders throughout childhood and adolescence. We also present recent longitudinal data from a sample of adolescents diagnosed with Cluster A personality disorders from our research laboratory, and suggest directions for future research in this important but understudied area.     

Coming Out Growth: Conceptualizing and Measuring Stress-Related Growth Associated with Coming Out to Others as a Sexual Minority

Coming out has long been depicted as a process that is conducive to personal growth. However, LGBTQ psychology has yet to conduct systematic, theoretically informed research to study how individuals experience coming out growth (COG) and the impact of such experiences on the lives of sexual minorities. The present investigation seeks to address these gaps in the literature through an examination of stress-related growth within the context of coming out as a sexual minority. Findings from a preliminary investigation of COG in a sample of 418 gay and lesbian adults are presented, including the development and initial validation of the coming out growth scale (COGS), and data addressing the relationship between COG and relevant constructs found in the literature on identity development and stress-related growth.     

Early Identification and Intervention for Behavior Problems in Primary Care: A Comparison of Two Abbreviated Versions of Parent-Child Interaction Therapy

Behavioral screening and preventive intervention were implemented for 3- to 6-year-olds in pediatric primary care with subclinical behavior problems. One hundred eleven children were screened with the Eyberg Child Behavior Inventory. Thirty children who scored within one standard deviation of the normative mean whose mothers indicated wanting help for their child's behavior were randomized to one of two abbreviated versions of Parent-Child Interaction Therapy (PCIT) for use in pediatric primary care: (a) a 4-session group preventive intervention called Primary Care PCIT (PC-PCIT); or (b) written materials describing basic steps of PCIT and guidelines for practice, called PCIT Anticipatory Guidance (PCIT-AG). Decreases in child problem behaviors and ineffective parenting strategies, and increases in parental feelings of control were not significantly different between versions at post-intervention or 6-month follow-up. Changes during intervention were significantly larger for both groups than changes during pretreatment baseline, with moderate to large effect sizes. These brief versions of PCIT are both promising primary care preventive interventions that deserve further study.