PKA and PKC are required for long-term but not short-term in vivo operant memory in Aplysia

We investigated the involvement of PKA and PKC signaling in a negatively reinforced operant learning paradigm in Aplysia, learning that food is inedible (LFI). In vivo injection of PKA or PKC inhibitors blocked long-term LFI memory formation. Moreover, a persistent phase of PKA activity, although not PKC activity, was necessary for long-term memory. Surprisingly, neither PKA nor PKC activity was required for associative short-term LFI memory. Additionally, PKA and PKC were not required for the retrieval of short- or long-term memory (STM and LTM, respectively). These studies have identified key differences between the mechanisms underlying nonassociative sensitization, operant reward learning, and LFI memory in Aplysia.     

Left-handedness and male-male competition: Insights from fighting and hormonal data

Male-male competition can shape some behavioral or morphological traits of males. Here we investigate if this competition could play a role in the persistence of the polymorphism of handedness in human populations. A negative frequency-dependent selection mechanism has been hypothesized, based on the fact that left-handed men may benefit from a "surprise" advantage during fighting interactions because they are rare in human populations. This advantage may thereby enhance the probability of survival of left- handed men and/or their reproductive success through an increase in social status. In this study, we first explored the association between hand preference and lifetime fighting behavior in a population of 1,161 French men. No effect of hand preference on the probability of fighting was detected, suggesting that the innate propensity to fight does not differ between left- and right-handers. However, among men who had been involved in at least one fight during their lifetime, left-handers reported significantly more fights than right-handers. To explore the biological basis of this behavior, we also investigated the testosterone concentration in saliva samples from 64 French university students. Consistent with frequencies of fights, we found a significantly higher average testosterone concentration in left-handers than in right-handers. We suggest that these behavioral and hormonal differences may be acquired throughout life due to previous experiences in a social context and may favor the persistence of left-handers in humans.     

Time perception and the internal clock: Effects of visual flicker on the temporal oscillator

Abstract

Our ability to estimate time intervals has sometimes been attributed to a biological source of temporal information. A model for a temporal oscillator that provides such information has recently been described (Treisman, Faulkner, Naish & Brogan, 1990). This predicts that an imposed stimulus rhythm at certain frequencies may interfere with the temporal oscillator so as to alter its frequency. This interference would cause perturbations in temporal judgements at certain frequencies of the imposed rhythm. The pattern of interference would depend on the frequency at which the temporal oscillator runs, and so would contain information about the oscillator frequency. Evidence for such a pattern was found when auditory clicks at different rates were presented concurrently with time intervals whose durations subjects estimated. The present study examines whether a similar interference pattern can be obtained if visual flicker is substituted for auditory clicks. On each trial, flicker was presented at a rate between 2.5 and 17.5 Hz, concurrently with a time interval to be estimated. A pattern of increased estimates at some rates and decreased estimates at others was obtained. This pattern showed similarities to interference patterns obtained using auditory clicks. This provides evidence that the entrainment of the internal clock predicted by the model can also be produced by visual inputs. Other theoretical implications are discussed.     

Slow wave sleep and recollection in recognition memory

Recognition memory performance reflects two distinct memory processes: a conscious process of recollection, which allows remembering specific details of a previous event, and familiarity, which emerges in the absence of any conscious information about the context in which the event occurred. Slow wave sleep (SWS) and rapid eye movement (REM) sleep are differentially involved in the consolidation of different types of memory. The study assessed the effects of SWS and REM sleep on recollection, by means of the "remember"/"know" paradigm. Subjects studied three blocks of 12 words before a 3-h retention interval filled with SWS, REM sleep or wakefulness, placed between 3 a.m. and 6 a.m. Afterwards, recognition and recollection were tested. Recollection was higher after a retention interval rich in SWS than after a retention interval rich in REM sleep or filled with wakefulness. The results suggest that SWS facilitates the process of recollection in recognition memory.     

Different cognitive processes in two image-scanning paradigms

Mental image scanning is generally assumed to be a single process that allows people to shift attention across visualized objects. However, this implicit assumption is open to question. We report a set of three experiments based on the tasks originally designed by Kosslyn, Ball, and Reiser (1978) and Finke and Pinker (1982). Participants scanned the identical images of an array of dots in the two tasks. Nevertheless, the participants required more time to shift their focus over the imaged stimulus in the Kosslyn et al. (1978) paradigm. Moreover, correlational analyses revealed no consistent relationship between the slopes of the increases in scanning times with increasing distances in the two paradigms. We conclude that in the Kosslyn et al. (1978) paradigm, the participants draw primarily on transformational processes to scan, whereas in the Finke and Pinker (1982) paradigm, they draw primarily on attentional processes. Both processes, transforming the image and shifting an attention window, produce linear increases in time with increases in distance, but for different reasons.     

Interactive Links Between Theory of Mind,Peer Victimization,and Reactive and Proactive Aggression

This study investigated the relation between theory of mind and reactive and proactive aggression, respectively, as well as the moderating role of peer victimization in this context. The 574 participants were drawn from a longitudinal study of twins. Theory of mind was assessed before school entry, when participants were 5 years old. Reactive and proactive aggression as well as peer victimization were assessed a year later in kindergarten. Results from multilevel regression analyses revealed that low theory of mind was related to a high level of reactive aggression, but only in children who experienced average to high levels of peer victimization. In contrast, a high theory of mind was related to a high level of proactive aggression. Again, this relation was especially pronounced in children who experienced high levels of peer victimization. These findings challenge the social skills deficit view of aggression and provide support for a multidimensional perspective of aggressive behavior.     

When scowling may be a good thing: The influence of anger expressions on credibility

Emotion displays do not only signal emotions but also have social signal value. A study was conducted to test the hypothesis that expressing anger when complaining may lead to positive outcomes for the complainant because anger signals goal obstruction and hence the presence of real harm. The results suggest that the social signal value of anger enhances the credibility of the complainant and hence leads to better compensation, but only when the complaint itself presents room for doubt. For highly justified complaints the additional expression of anger does not add information and is discounted. In contrast, showing an affiliative‐smiling demeanor was found to enhance credibility for both types of complaints. Overall, the present research confirmed the important role of emotion expressions as social signals. Copyright © 2008 John Wiley & Sons, Ltd.     

Variations in watch keeping performance as a function of the rate and duration of visual signals

This study was designed to assess the relative effects on watch keeping performance of five signal durations (0.5, 1.0, 2.0, 4.0, and 8.0sec) combined factorially with five signal rates (6, 12, 24, 48, and 96 sig/h). A visual display consisting of a red and green light mounted on a vertical vector was used; red-onset and green-offset were critical signals. The probability of correct detections increased monotonically with increases in signal duration; a stable rate of nearly 100% detection was approached at signal durations of 4.0 and 8.0 sec, independently of signal rates. The likelihood of detection was enhanced by increases in signal rates only at the 0.5-sec duration with the green-offset critical signal. Response time to correct detections increased with time on watch, independently of signal rates and durations.     

When one-two-three beats two-one-three: Tracking the acquisition of the verbal number sequence

Psychonomic Bulletin & Review - Learning how to count is a crucial step in cognitive development, which progressively allows for more elaborate numerical processing. The existing body of...     

Contribution of nesting experience to progesterone-induced incubation in ring doves (Streptopelia risoria)

Injections of progesterone induce incubation behavior in gonadally intact ring doves only if the doves have had previous experience with at least the nest-building phase of a breeding cycle. The present study was designed to determine whether exposure to progesterone during the nest-building phase is sufficient to account for the ability of progesterone to induce incubation at a later time or whether some other factor provided by experience with this phase of the cycle is needed. Six groups of 10 pairs of doves each were provided with different combinations of experience and progesterone priming. Progesterone priming combined with social isolation or with courtship experience had no significant effect on subsequent progesterone-induced incubation. However, doves that participated in the nesting phase of the cycle during progesterone priming later incubated in response to progesterone treatment. Nesting activity, which may or may not include building the nest, seemed to be the relevant experience.