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861.
Cholinergic-dopaminergic interactions in cognitive performance 总被引:1,自引:0,他引:1
Both acetylcholinergic (ACh) and dopaminergic (DA) systems have been found to be crucial for the maintenance of accurate cognitive performance. In a series of studies examining those aspects of cognitive function revealed by the radial-arm maze, we have found that these two neurotransmitter systems interact in a complex fashion. Choice accuracy deficits in the radial-arm maze can be induced by blockade of either muscarinic- or nicotinic-ACh receptors. The choice accuracy deficit induced by blockade of muscarinic receptors with scopolamine can be reversed by the DA receptor blocker, haloperidol. The specific DA D1 blocker SCH 23390 also has this effect, whereas the specific D2 blocker raclopride does not, implying that it is D1 blockade that is critical for reversing the scopolamine effect. On the other hand, the choice accuracy deficit induced by nicotinic blockade with mecamylamine is potentiated by haloperidol. This effect is also seen with the D2 antagonist raclopride, but not with the D1 antagonist SCH 23390, implying that it is the D2 receptor which is important for the potentiation of the mecamylamine effect. The relevance of the D2 receptor for nicotinic actions on cognitive function is emphasized by the finding that the selective D2 agonist LY 171555 reverses the choice accuracy deficit caused by mecamylamine. Nicotinic and muscarinic blockade are synergistic in the deficit they produce. Antagonist doses subthreshold when given alone produce a pronounced impairment when given together. This latter deficit can be reversed by the D2 agonist LY 171555. These studies have outlined the complex nature of ACh-DA interactions with regard to cognitive function. Possible neural circuits for these interactions are discussed. The effectiveness of these selective DA treatments in reversing cognitive deficits due to ACh underactivation suggests a novel approach to treating cognitive dysfunction in syndromes such as Alzheimer's disease. 相似文献
862.
Ethanol-mediated taste aversions and state-dependency in preweanling (16-day-old) rats 总被引:1,自引:0,他引:1
Requirements for conditioning of an ethanol-mediated taste aversion in 16-day-old rat pups were examined. Experiment 1 demonstrated that preweanling rats are capable of acquiring, in two trials, an aversion to a 15% sucrose solution when followed by intragastric intubation of a 1.2 g/kg dose of 17% v/v ethanol, but not when followed by a 0.4 g/kg dose. Comparison was with control animals given sucrose followed by an equivalent volume isocaloric Half and Half. When the 0.4 g/kg dose of ethanol preceded sucrose presentation by 30 min (Experiment 2), the aversion was learned, suggesting that the effective delay between the sucrose and the critical consequences of the ethanol had been too long with the former procedure. Expression of the sucrose aversion required, however, the reinstatement of the context of intoxication--state-dependent retention. Finally, the results of Experiment 3B indicated that, in addition to the association between the sucrose and the aversive consequences of alcohol intoxication, the orosensory cues resulting from alcohol's direct elimination, via such processes as respiration and salivation, became associated with the appetitive properties of the sucrose. This was evidenced by a conditioned increase in preference for ethanol odor. Possible age-related differences in the ability to associate stimuli with alcohol's unconditioned consequences, and in state dependency are discussed. 相似文献
863.
Glucose and physostigmine effects on morphine- and amphetamine-induced increases in locomotor activity in mice 总被引:2,自引:0,他引:2
Recent findings indicate that glucose antagonizes several behavioral effects of cholinergic antagonists and augments those of cholinergic agonists. For example, scopolamine elicits increased locomotor activity, an action which is attenuated by glucose and by combined treatment with glucose and physostigmine at doses which are individually without effect. Opiate and catecholamine agonists, such as morphine and amphetamine, also elicit hyperactivity. The present study examined interactions of glucose and physostigmine with morphine- and amphetamine-induced hyperactivity. Mice received saline, morphine (10 mg/kg), or amphetamine (1 mg/kg) 50 min prior to testing, followed by saline, physostigmine (0.01, 0.05, 0.1, or 0.2 mg/kg), or glucose (10, 50, 100, or 500 mg/kg) administered 20 min prior to activity testing in an open field. Physostigmine significantly attenuated both morphine- and amphetamine-induced increases in activity, but higher doses were required to attenuate the effects of amphetamine. Like physostigmine, glucose significantly attenuated morphine-induced activity levels, but unlike physostigmine, glucose did not attenuate amphetamine-induced activity. Thus, the behavioral effects of morphine were more susceptible to modification by physostigmine and glucose than were the effects of amphetamine. The attenuation of morphine-induced hyperactivity demonstrates a similarity between glucose and cholinergic agonists, and also indicates that glucose may inhibit, directly or indirectly, opiate functions. More generally, these findings add to the evidence that circulating glucose levels selectively influence a growing list of behavioral and neurobiological functions. 相似文献
864.
865.
Marked differences in detectability as a function of spatial location, a "detectability gradient," are observed when subjects are required to detect a briefly exposed target pattern of uncertain location in the presence of a number of nontarget patterns. Target detectability also is inversely related to the number of nontarget patterns which are present in this search paradigm. These previous findings provide strong evidence for a serial process in which increasing probability of error occurs during a scan of a rapidly degrading neural representation of the visual image following a brief exposure to the stimuli. It is not yet established whether this scan is attentional or perceptual in nature. The present experiments test the hypothesis of an attentional scan by presenting the target and nontarget patterns in spatially segregated groups. If the scan is attentional, then target detectability under these circumstances would be expected to exhibit the characteristic phenomenon of "group processing"--a close clustering of detection performance for targets located within a group and large differences in detectability across groups. As no evidence for group processing was observed, the results fail to support the view that the scan is attentional in nature but are fully consistent with a nonattentional scan. 相似文献
866.
Previous experiments in this laboratory employing a search paradigm have found highly significant differences in the detectability of a briefly exposed target pattern as a function of the spatial location of the target when it is presented simultaneously with a number of discriminably different nontarget patterns. These detectability differences, at loci equidistant from the fovea, could not be accounted for by any known variation in retinal spatial resolution or by differential lateral masking effects of the target by nearby nontarget patterns. These observations led to the hypothesis that the target in these experiments was detected by a serial mechanism which "scanned" a persisting but rapidly degrading neural representation of the visual scene with increasing detection failures the later in time the scan processed the location occupied by the target. If this hypothesis is correct, then target detectability should vary inversely with the number of stimuli which must be examined. The present experiment confirmed this expectation. A mathematical model of such a serial scanning process also predicts other, less obvious, effects on target detectability which were observed when the number of nontarget patterns was changed. 相似文献
867.
Peter N. Kugler Robert E. Shaw Kim J. Vincente Jeffrey Kinsella-Shaw 《Psychological research》1990,52(2-3):98-121
Summary The role of intention in guiding the behavior of goal-directed systems is a problem that continues to challenge behavioral science. While it is generally agreed that intentional systems must be consistent with the laws of physics, there are many obvious differences between inanimate, physical systems and sentient, intentional systems. This suggests that there must be constraints over and above those of physics that govern goal-directed behavior. In this paper it is suggested that generic properties of self-organizing mechanisms may play a central role in the origin and evolution of intentional constraints. The properties of self-organizing systems are first introduced in the context of simple physical systems and then extended to a complex (biological) system. Whereas behavior of an inanimate physical system is lawfully determined by force fields, behavior of an animate biological system is lawfully specified by information fields. Biological systems are distinguished from simple physical systems in terms of their ubiquitous use of information fields as special (biological and psychological, social, etc.) boundary conditions on classical laws. Unlike classical constraints (boundary conditions), informational constraints can vary with time and state of the system. Because of the nonstationarity of the boundary conditions, the dynamic of the system can follow a complex trajectory that is organized by a set of spatially and temporally distributed equilibrium points or regions. It is suggested that this equilibrium set and the laws that govern its transformation define a minimal requirement for an intentional system. One of the benefits of such an approach is that it suggests a realist account for the origin of semantic predicates, thereby providing a basis for the development of a theory of symbolic dynamics. Therefore, the principles of self-organization provide a comprehensive basis for investigating intentional systems by suggesting how it is that intentions arise, and by providing a lawful basis for intentional behavior that reveals how organisms become and remain lawfully informed in the pursuit of their goals. 相似文献
868.
Are women in a female-dominated profession more successfully able to combine work and family obligations than women in a male-dominated profession? To explore this question, a comparison was made between the family status and careers of 747 women librarians (a female-dominated profession) and those of 449 women MBAs (a male-dominated profession). It was expected that the librarians would marry earlier and have more children. This general prediction was not supported. Over half of both groups of women were married, and after controlling for age, there were no differences in number of children. However, many women without children in both groups reported that they would like to be mothers. This disparity between wanting children and not having them was more common for women MBAs than women MLSs. MBAs and librarians were about equally likely to have had job interruptions, but librarians were more likely to have worked part-time. Reasons for an interruption to full-time work were as likely to be for problems finding (full-time) work as for family responsibilities. Librarians' salaries were much lower, but job interruptions and part-time work had a more negative effect on the salaries of women in business. In sum, the data suggest that many of the women surveyed have not combined motherhood with a professional career and that it is probably somewhat more difficult to combine a family with a career in business than with a career in library science. 相似文献
869.
This study tested the applicability of Tajfel and Turner's (1986) Social Identity Theory (SIT) to cooperative behavior in a mixed-gender setting. SIT suggests that as a “socially subordinate” group in a male-dominated society, women, when their gender is in the numerical minority, will engage in social competition in an attempt to enhance social identity. However, gender-based socialization may encourage men toward competition and women toward cooperation, regardless of group gender composition. In this study, male and female subjects were assigned to a six-person mixed-gender group in which their gender was either in the numerical minority or majority, and performed an interactive task under either cooperative or competitive feedback. An interaction of sex and feedback showed males in the cooperative feedback condition responded more competitively than did males in the competitive feedback condition, while females were equally cooperative in both feedback conditions. Feedback also interacted with the numerical ingroup/outgroup gender balance. While competitive feedback elicited little variation in subjects' responses across the ingroup/outgroup balance variable, the cooperative condition elicited greater competition from subjects in the numerical minority and greater cooperation from those in the numerical majority. Results were interpreted as partial support for SIT, while stressing the need for further investigation into gender as a unique influence on intergroup behavior. 相似文献
870.