Amygdalar Volume in Borderline Personality Disorder With and Without Comorbid Post-traumatic Stress Disorder: A Meta-analysis

IntroductionFour studies have found a smaller amygdalar volume in patients with borderline personality disorder (BPD) relative to controls, whereas four other studies have found similar amygdalar volume in BPD patients relative to controls. This study aims to compare amygdalar volumes of BPD patients with controls, and also to compare BPD patients with and without post-traumatic stress disorder (PTSD) with controls in order to determine whether PTSD can explain the heterogeneity of findings.MethodSystematic review and meta-analysis of magnetic resonance imaging studies that measured amygdalar volumes in BPD patients and healthy controls.FindingsA significant reduction of amygdalar volumes in BPD patients was confirmed (p < .001). However, data from the studies that discriminated BPD patients with and without PTSD indicated that amygdalar volumes were significantly smaller in BPD patients without PTSD relative to controls (left: p = .02; right: p = .05), but not in BPD patients with PTSD relative to controls (left: p = .08; right: p = .20).ConclusionThis meta-analysis suggests that amygdalar volumes are reduced in patients with BPD. This pattern is confirmed in BPD patients without PTSD, but not in BPD patients with PTSD, raising the possibility that reduced amygdalar volume in BPD patients cannot be explained by comorbid PTSD.     

Utility of a statistical model of cognitive styles in attention deficit hyperactivity disorder

The purpose of this study was to determine the best statistical model of cognitive styles, based on the MFFT-20, CEFT and Stroop tests to predict attention deficit hyperactivity disorder (ADHD), analyzing the validity of the model for the diagnosis of the disease. We studied 100 ADHD cases (DSM-IV criteria) and 100 controls, age ranging between 7 and 11 years. Controls were randomly recruited and matched in age, gender and sociodemographic area with ADHD cases. On average, ADHD cases showed more impulsiveness (d: 1.28), less cognitive flexibility (d: 0.91) and more field dependence (d: 1.62) than controls. The logistic regression model that predicts ADHD best is made up of age, CEFT, MFFT-20 and Stroop tests and the formula derived from the model shows 85% sensitivity and 85% specificity for ADHD, regarding the DSM-IV criteria as the standard. The statistical model of cognitive styles presents valid indicators to diagnose ADHD, contributing to an increase in the objectivity of its analysis.     

The biochemical bases of the placebo effect

A great variety of medical conditions are subject to the placebo effect. Although there is mounting evidence to suggest that the placebo effect is related to the expectation of clinical benefit, little is still known about the biochemical bases underlying placebo responses. Positron emission tomography studies have recently shown that the placebo effect in Parkinson’s disease, pain, and depression is related to the activation of the limbic circuitry. The observation that placebo administration induces the release of dopamine in the ventral striatum of patients with Parkinson’s disease suggests a link between the placebo effect and reward mechanisms. In addition to Parkinson’s disease, the placebo-reward model may also apply to other disorders. However, the relative contribution of the different neurotransmitters and neuropeptides that are known to be involved in modulating the activity of the limbic system may be disease-specific. Thus, while the placebo-induced clinical benefit observed in Parkinson’s disease would mostly reflect the release of dopamine in the dorsal striatum, the activation of opioid and serotonin pathways could be particularly implicated in mediating placebo responses encountered in pain and depression, respectively. An earlier version of this paper was presented at an international conference, “Placebo: Its Action and Place in Health Research Today,” held in Warsaw, Poland on 12–13 April, 2003.     

Concurrent guidance of attention by multiple working memory items: Behavioral and computational evidence

During visual search, task-relevant representations in visual working memory (VWM), known as attentional templates, are assumed to guide attention. A current debate concerns whether only one (Single-Item-Template hypothesis; SIT) or multiple (Multiple-Item-Template hypothesis; MIT) items can serve as attentional templates simultaneously. The current study was designed to test these two hypotheses. Participants memorized two colors, prior to a visual-search task in which the target and the distractor could match or not match the colors held in VWM. Robust attentional guidance was observed when one of the memory colors was presented as the target (reduced response times (RTs) on target-match trials) or the distractor (increased RTs on distractor-match trials). We constructed two drift-diffusion models that implemented the MIT and SIT hypotheses, which are similar in their predictions about overall RTs, but differ in their predictions about RTs on individual trials. Critically, simulated RT distributions and error rates revealed a better match of the MIT hypothesis to the observed data than the SIT hypothesis. Taken together, our findings provide behavioral and computational evidence for the concurrent guidance of attention by multiple items in VWM.

     

Evaluation of Breast Cancer Patients with Genetic Risk in a University Hospital: Before and After the Implementation of a Heredofamilial Cancer Unit

The identification of patients at risk for breast cancer by genetic testing has proven to reduce breast cancer mortality. In 2010, due to a lack of systematization in hereditary cancer assistance in our center, we implemented a multidisciplinary Heredofamilial Cancer Unit (HFCU). We analyze if the HFCU improved the rates of referrals and preventive management of breast cancer patients with genetic risk. We retrospectively compared family history records, referrals of high-risk patients to genetic counseling, and detection and management of patients with BRCA1/2 mutations in two cohorts of breast cancer patients diagnosed before (first period: 2007–2010) and after the creation of the HFCU (second period: 2010–2013). In the first period, 893 patients were included, and 902 were included in the second. Due to the inability to establish their genetic risk, 142 patients (15.9%) vs. 70 (7.8%) were excluded from analysis (p?<?0.001). Among the evaluable patients, 194 (25.8%) vs. 223 (26.8%) fulfilled one or more risk criteria (p?=?0.65). Family history documentation in patient’s medical records (92.4 vs. 97.8%, p?<?0.001) and referral rate (26.3 vs. 52%, p?<?0.0001) significantly increased in the second period. Eight BRCA1/2 mutations were detected among patients referred in the first period and 17 among those referred to the HFCU. The rate of preventive surgeries in patients with BRCA mutations significantly increased in the second period (25 vs. 76.5%, p?=?0.03). In conclusion, there was a clear improvement in family history records, referrals, and preventive surgeries in breast cancer patients with genetic risk after the implementation of the HFCU.     

Working memory in the oldest-old: evidence from output serial position curves

In the present study, we examined adult age differences in short-term and working memory performance in middle-aged (45–64 years), young–old (65–74 years), old–old (75–89 years), and oldest–old adults (90 years and over) in the Louisiana Healthy Aging Study. Previous research suggests that measures of working memory are more sensitive to age effects than are simple tests of short-term memory Bopp and Verhaeghen (Journal of Gerontology: Psychological Sciences 60:223–233, 2005), Myerson, Emery, White, and Hale, (Aging, Neuropsychology, and Cognition 10:20–27, 2003). To test this hypothesis, we examined output serial position curves of recall data from three span tasks: forward and backward digit span and size judgment span. Participants’ recall patterns in the size judgment span task revealed that the two oldest groups of adults showed the largest decreases in recall performance across output serial positions, but did not differ significantly from each other. Correlation analyses indicated the strongest negative correlation with age occurred with the size judgment span task. Implications of these findings for understanding strategic processing abilities in late life are discussed.     

Social Perception of Rape Victims in Dating and Married Relationships: The Role of Perpetrator’s Benevolent Sexism

Two hypothetical scenario studies examined how situational, perpetrator, and observer factors affect blame towards rape victims. In Study 1, Spanish high school students (N?=?206) read about a rape committed by a boyfriend or husband who was described as benevolently sexist or not. Study 2 (N?=?201 British college students) replicated and extended Study 1 by adding a condition in which the rapist was described as a hostile sexist. In both studies, participants’ benevolent sexism scores predicted more victim blame when the rapist was described as a husband (but not a boyfriend) who held benevolently sexist attitudes. Study 2 showed that participants’ hostile sexism scores predicted more victim blame when the rapist was described as a hostile sexist.     

Object-based eye movements: The eyes prefer to stay within the same object

The present study addressed the question of whether we prefer to make eye movements within or between objects. More specifically, when fixating one end of an object, are we more likely to make the next saccade within that same object or to another object? Observers had to discriminate small letters placed on rectangles similar to those used by Egly, Driver, and Rafal (1994). Following an exogenous cue, observers made a saccade to one end of one of the rectangles. The small target letter, which could be discriminated only after it had been fixated, could appear either within the same or at a different object. Consistent with object-based attention, we show that observers prefer to make an eye movement to the other end of the fixated same object, rather than to the equidistant end of a different object. It is concluded that there is a preference to make eye shifts within the same object, rather than between objects.     

MANULEX: A grade-level lexical database from French elementary school readers

This article presents MANULEX, a Web-accessible database that provides grade-level word frequency lists of nonlemmatized and lemmatized words (48,886 and 23,812 entries, respectively) computed from the 1.9 million words taken from 54 French elementary school readers. Word frequencies are provided for four levels: first grade (G1), second grade (G2), third to fifth grades (G3-5), and all grades (G1-5). The frequencies were computed following the methods describedby Carroll, Davies, and Richman (1971) and Zeno, Ivenz, Millard, and Duwuri (1995), with four statistics at each level (F, overall word frequency;D, index of dispersion across the selectedreaders;U, estimated frequencyper million words; andSFI, standard frequency index). The database also provides the number of letters in the word and syntactic category information. MANULEX is intended to be a useful tool for studying language development through the selection of stimuli based on precise frequency norms. Researchers in artificial intelligence can also use it as a source of information on natural language processing to simulate written language acquisition in children. Finally, it may serve an educational purpose by providing basic vocabulary lists.     

Expertise effects on decision-making in sport are constrained by requisite response behaviours – A meta-analysis

ObjectivesA quantitative review of the effects of requisite responses and methods of stimulus presentation for assessing decision-making expertise in sport was undertaken.DesignAn electronic literature search was conducted in the online databases: SPORTDiscus with Full Text and ISI Web Knowledge All Databases. Articles for analysis were selected according to prior defined criteria.MethodsWe considered 111 effect sizes in studies involving 882 expert and non-expert participants. Effect sizes were calculated for six common protocols for measures responses: verbalized knowledge, eye movement measures, decision time, response accuracy, movement accuracy, and movement time. Two moderator variables were also considered to assess effects of research protocols on the dependent variables: “the requisite response” and “stimulus presentation”. A random effect model was used to calculate effect sizes.ResultsAnalysis of moderator variables suggested that expertise effects were more apparent for “requisite responses” when participants were required to actually perform sporting actions and for “stimulus presentation” under in situ task constraints than for other conditions.ConclusionsFuture empirical work on expertise and decision-making needs to consider task representativeness in considering requisite responses of participants in simulating performance environment conditions. Use of representative task constraints with performers required to perform sport actions in in situ conditions appeared the most functional empirical protocols to enhance validity of data.