Brain network dysfunction in bipolar disorder

Bipolar disorder is a common psychiatric condition with significant associated morbidity and mortality. Despite its significance, the neurophysiology and neuropathology of this illness is incompletely understood. Recent advances in neuroimaging techniques have helped to begin clarifying these areas. Specifically, bipolar disorder appears to arise from abnormalities within discrete brain networks (eg, the anterior limbic network). The expression of the symptoms of bipolar disorder does not appear to result from single, localized brain lesions, but rather are emergent properties of dysfunction of these brain networks. As neuroimaging techniques continue to improve, the underlying neural basis of bipolar disorder will be clarified.     

Evaluating a split processing model of visual word recognition: effects of orthographic neighborhood size

The split fovea theory proposes that visual word recognition of centrally presented words is mediated by the splitting of the foveal image, with letters to the left of fixation being projected to the right hemisphere (RH) and letters to the right of fixation being projected to the left hemisphere (LH). Two lexical decision experiments aimed to elucidate word recognition processes under the split fovea theory are described. The first experiment showed that when words were presented centrally, such that the initial letters were in the left visual field (LVF/RH), there were effects of orthographic neighborhood, i.e., there were faster responses to words with high rather than low orthographic neighborhoods for the initial letters ('lead neighbors'). This effect was limited to lead-neighbors but not end-neighbors (orthographic neighbors sharing the same final letters). When the same words were fully presented in the LVF/RH or right visual field (RVF/LH, Experiment 2), there was no effect of orthographic neighborhood size. We argue that the lack of an effect in Experiment 2 was due to exposure to all of the letters of the words, the words being matched for overall orthographic neighborhood count and the sub-parts no longer having a unique effect. We concluded that the orthographic activation found in Experiment 1 occurred because the initial letters of centrally presented words were projected to the RH. The results support the split fovea theory, where the RH has primacy in representing lead neighbors of a written word.     

Abortion among adolescents

In most countries, adolescents' access to abortion is limited by restrictions on legal abortion. Abortion is legal in the United States, but many states require parental consent or notification. Legislation mandating parental consent has been justified by several assumptions, including high risk of psychological harm from abortion, adolescents' inability to make an adequately informed decision, and benefits of parental involvement. Empirical data raise questions about the first 2 assumptions: Studies suggest a relatively low risk associated with abortion, and adolescents seeking abortion appear to make an informed choice. Less is known about effects of parental involvement. The authors review available research and discuss policy debates over parental consent in the United States and the international context.     

The effects of divided attention at encoding on item and associative memory

Divided attention at encoding is well known to have adverse effects on episodic memory performance (e.g., Naveh-Benjamin & Greg, 2000). This article attempts to determine whether these effects are a result of the interruption of encoding of associative information among the components of an episode. Five experiments, using different types of episodes and episodes components, were conducted. Participants studied information under either full or divided attention and were then tested on their memory for both the episodes' components and the associations between them. Divided attention did not produce a differential deficit in memory for associative information; memory for the components suffered to the same degree as memory for the associations among the components. The cause of the divided-attention effect at encoding lies somewhere other than in the associative processes that are engaged.     

The neural reality of syntactic transformations: evidence from functional magnetic resonance imaging

The functional anatomy of syntactic transformations, a major computational operation invoked in sentence processing, was identified through a functional magnetic resonance imaging investigation. A grammaticality judgment task was used, presented through a novel hidden-blocks design. Subjects listened to transformational and nontransformational sentences in which a host of other complexity generators (number of words, prepositions, embeddings, etc.) were kept constant. A series of analyses revealed that the neural processing of transformations is localizable, evoking a highly lateralized and localized activation in the left inferior frontal gyrus (Broca's region) and bilateral activation in the posterior superior temporal sulcus. The pattern of activation associated with transformational analysis was distinct from the one observed in neighboring regions, and anatomically separable from the effects of verb complexity, which yielded significant activation in the left posterior superior temporal sulcus. Taken together with neuropsychological evidence, these results uncover the neural reality of syntactic transformations.     

Beyond neutrality – a politically oriented systemic intervention

This paper focuses on the necessity to expand some perspectives of systemic interventions beyond the therapeutic room. It relates to situations where the problem presented by the client system arises from a political ideology that marginalizes the client system. The consideration of new alternatives requires a dialogue about the ideology of the client system and the ideologies held by others – the therapist, the people in the main stream, etc. Balancing between sharing therapist prejudices, i.e. political ideology, being neutral in understanding the narrative and meaning of the client system ideology, and being irreverent towards all ideologies, is useful in enabling the consideration of new alternatives. This is illustrated by the case of a supervisor/dialogue process with a group of Jewish family therapists living in the situation of political uncertainty on the West Bank of the Jordan, an area that has been occupied by Israel for three decades and a focal point of the changes proscribed by the Oslo Peace Agreement.     

Effect of Mode of Adjudication,Presence of Defense Counsel,and Favorability of Verdict on Observers' Evaluation of a Criminal Trial1

In an experimental simulation, observers evaluated one of four different legal procedures in the presence of either a favorable or unfavorable outcome in a video-taped reenactment of a criminal trial. The procedures were adversarial, inquisitorial, adversarial without lawyer, and adversarial with plea bargaining. Data were gathered on the fairness and perceived satisfaction of the defendant with the final outcome, and quality of the defense and prosecution. Contrary to previous research, results showed that the several different procedures were seen as equally fair and legitimate, which suggests that how a procedure is implemented may be more important than its structural properties in observers' overall evaluations. It was also found that defendants are seen as least satisfied when the ostensibly fairest procedure (eg, adversarial) yields an unfavorable outcome. This finding supports a frustration interpretation and contradicts previous studies which report adversarial to be the most preferred dispute resolution procedure within all outcome conditions.     

Infants' eyewitness testimony: Effects of postevent information on a prior memory representation

In eyewitness testimony research, postevent information impair retention of the original event and increases the probability that interpolated information will be identified as part:of the original event. The present experiments studied these effects with 3-month-olds. Infants learned to kick to move a particular crib mobile and then were briefly exposed to information about a novel mobile. The novel postevent information impaired recognition of the-original mobile when it immediately followed training but not when it was delayed by 1 day. Like adults, infants treated the postevent information as part of the original training event, continuing to do so for at least 2 weeks. We propose that postevent information displaces conflicting information coactive with it in primary memory and creates a new, updated memory token of the event. Once the new token leaves primary memory, however, it is protected; only a copy can be retrieved and modified in the future.     

Relationship of subjective and objective social status with psychological and physiological functioning: preliminary data in healthy white women.

This preliminary study compared the associations between objective and subjective socioeconomic status (SES) with psychological and physical variables among 157 healthy White women, 59 of whom subsequently participated in a laboratory stress study. Compared with objective indicators, subjective social status was more consistently and strongly related to psychological functioning and health-related factors (self-rated health, heart rate, sleep latency, body fat distribution, and cortisol habituation to repeated stress). Most associations remained significant even after controlling for objective social status and negative affectivity. Results suggest that, in this sample with a moderately restricted range on SES and health, psychological perceptions of social status may be contributing to the SES-health gradient.