Spatial and visual learning deficits in Alzheimer's and Parkinson's disease

Experimental paradigms adopted from animal models were used to compare the neuropsychological mechanisms underlying the dementias of Alzheimer's and Parkinson's diseases. Two tasks were selected because characteristic profiles of impairment in nonhuman primates are seen following selective lesions of frontal cortex, temporal cortex, and fornix. The tasks consisted of a spatial and a visual learning problem, each with two components: (1) original learning and (2) reversal of the original learning. The Alzheimer's patients were significantly impaired on original learning and reversal learning in the visual modality compared with demented Parkinson's patients, even though both groups were equated for severity of dementia. On the spatial tasks, both the Alzheimer's and the demented Parkinson's patients were impaired on reversal learning but not on original learning. The profile of deficits on the visual tasks may serve to differentiate Alzheimer's from Parkinson's dementia and may reflect selective orbitofrontal system lesions in the former.     

On the development of procedural knowledge

Amnesic patients demonstrate by their performance on a serial reaction time task that they learned a repeating spatial sequence despite their lack of awareness of the repetition (Nissen & Bullemer, 1987). In the experiments reported here, we investigated this form of procedural learning in normal subjects. A subgroup of subjects showed substantial procedural learning of the sequence in the absence of explicit declarative knowledge of it. Their ability to generate the sequence was effectively at chance and showed no savings in learning. Additional amounts of training increased both procedural and declarative knowledge of the sequence. Development of knowledge in one system seems not to depend on knowledge in the other. Procedural learning in this situation is neither solely perceptual nor solely motor. The learning shows minimal transfer to a situation employing the same motor sequence.     

Parts of visual objects: an experimental test of the minima rule

Three experiments were conducted to test Hoffman and Richards's (1984) hypothesis that, for purposes of visual recognition, the human visual system divides three-dimensional shapes into parts at negative minima of curvature. In the first two experiments, subjects observed a simulated object (surface of revolution) rotating about a vertical axis, followed by a display of four alternative parts. They were asked to select a part that was from the object. Two of the four parts were divided at negative minima of curvature and two at positive maxima. When both a minima part and a maxima part from the object were presented on each trial (experiment 1), most of the correct responses were minima parts (101 versus 55). When only one part from the object--either a minima part or a maxima part--was shown on each trial (experiment 2), accuracy on trials with correct minima parts and correct maxima parts did not differ significantly. However, some subjects indicated that they reversed figure and ground, thereby changing maxima parts into minima parts. In experiment 3, subjects marked apparent part boundaries. 81% of these marks indicated minima parts, 10% of the marks indicated maxima parts, and 9% of the marks were at other positions. These results provide converging evidence, from two different methods, which supports Hoffman and Richard's minima rule.     

The relationship between variability of intertap intervals and interval duration

Summary Subjects tracked intervals in a synchronization paradigm at interval durations of 180, 210, 240, 270, 300, 400, 500, 600, 700, 800, 900, and 1,000 ms. The variability of intertap intervals (ITIs) shows a sudden increase near 300 ms. This increase is interpreted as indicating the transition from automatic to controlled movement. It is suggested that the sudden change in the variability of ITIs does not reflect the operation of different timing mechanisms at short and long intervals, but differences in the way in which attentional processes come to bear on movement initiation for different interval durations. In contrast to previous findings reported in the literature, a U-shaped function between interval duration and variability in the 300-to-1,000-ms range was not observed.     

Lesbian Partner Abuse: Implications for Therapists

Silence surrounds the issue of lesbian battering. Lesbian victims of partner abuse are even less likely than are their heterosexual counterparts to seek help in shelters or from counselors because of the overlay of homophobia that exists both in the battered women's movement and among mental health professionals. In addition, many lesbian and many lesbian-supportive therapists hold an idealized and unrealistic picture of the nature of lesbian relationships, leading them to deny the existence of buttering among lesbian couples. The nature, severity, and prevalence of abuse in lesbian relationships is addressed; current counseling and treatment models dealing with battering relationships are analyzed; and a counselor advocacy model for working with lesbian partner abuse, drawing from the experience of activists in the battered women's movement and our clinical experience, is suggested.     

Relationship of severity of dementia to caregiving stressors

In studies of individual differences and longitudinal changes in stress and coping among dementia caregivers, assessing severity of patient impairment is critically important. It is proposed that with the progression of dementia, cognitive impairment may steadily increase, but other stressful behavioral symptoms peak at various stages of dementia. Cross-sectional data from 49 caregiving families and longitudinal follow-up data from 48 families suggest that instrumental self-care deficits begin early in dementia, and basic self-care deficits increase with dementia severity, but that many distressing behavioral symptoms decrease in late dementia. Assessments of dementia patient severity should be multidimensional, and increases and decreases in various dementia patient stressors over time should be considered as factors influencing caregiver coping.     

Forecasting the impact of the federal sentencing guidelines

The Sentencing Reform Act of 1984, which created the U.S. Sentencing Commission, required that the commisson consider prison capacity in drafting sentencing guidelines. As part of the commission's efforts to meet this requirement, we developed a computer simulation capable of projecting the impact of the commission's guidelines on future sentences and prison populations. According to our projections, “straight” probation sentences will be reduced significantly under the guidelines. However, reducing the use of probation will generate only modest demands on the prisons, and then mostly for community corrections phased in over the course of 5 years. We also project that, while average time served for violent offenses will increase substantially, average time served for most property crimes will remain largely the same. Finally, while we forecast that federal prison populations will grow markedly by the end of this century, this is more a result of the Anti-Drug Abuse Act of 1986 and the career offender provision of the Comprehensive Crime Control Act of 1984 than a result of the guidelines.     

Central-place foraging by Rattus norvegicus on a radial maze

We studied central-place foraging in rats (Rattus norvegicus) by placing food items that varied in size and weight at the ends of a 4-arm radial maze. In Experiments 1-3, rats increasingly tended to carry food to the center of the maze as the size of those items increased. Very large food items often were hoarded in the center. Rats consumed food faster on the arms than in the center, and rats traveled faster when carrying food than when not. Blocking arm entrances increased travel time between the center and the arms and decreased food carrying at every item weight except the largest. In Experiments 4-6, important conditions that influence the degree of food-carrying behavior were discovered; these were the intersection of maze arms, the presence of a conspecific, and the use of open vs. closed maze arms.