Differential indications for desipramine--results of a controlled multiclinical study]

The antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective symptoms, which was not detectable for the inhibition of drive. The tachythymoleptic action of desipramine is discussed with reference to these results. Evaluation of the possibility of controlling affects shows different ranges of activity of desipramine and imipramine, with desipramine influencing especially negative psychoenergetic symptoms in the area of drives and emotions and imipramine, restrictive symptoms in addition to differential phenomena of the psychomotor expression.     

Barriers to Adult Career Change

Adults have unique problems in making career changes. They face crucial economic, educational, and psychological barriers that require special guidance services. In this article, barriers to adult career change are identified and a five-county regional learning service using paraprofessionals is described. Results in working with more than 200 adults making career changes is reported. Suggestions for overcoming some of the problems adults face in making career changes are explained.     

Statistical significance tests for binormal ROC curves

Statistical significance tests are derived and evaluated for measuring apparent differences between an obtained and an expected binormal ROC curve, between two independent binormal ROC curves, and among groups of independent binormal ROC curves. A binormal ROC curve is described by two parameters which represent the spread of the means and the ratio of the standard deviations of the two underlying Gaussian decision variable distributions. To test the significance of apparent differences between or among ROC curves, approximate χ² statistics for each of the three tests were constructed from maximum likelihood estimates of the two parameters defining the binormal ROC curve. The performance of each test statistic was evaluated by simulating five-category rating scale data with equal numbers of noise and signal-plus-noise trials (set at 50, 250, and 500) for each of three typical ROC curves. For the significance test involving only one ROC curve, rating scale data were generated from the chance diagonal of the ROC space also. Although test performance was found to be somewhat dependent on the number of trials and on the location of the ROC curve in the ROC space, comparisons of the obtained and expected fractions of (falsely) significant results at various α levels showed the proposed statistical significance tests to be reliable under practical experimental conditions.     

A vector graphic CRT display system

A vector graphic CRT display system for research in visual information processing is described. The vector graphic processor includes a 4K-byte display memory. The processor communicates with the controlling computer via a serial channel. The system is capable of exposure durations below 1 msec, and it allows on-line generation and modification of display files during an experiment. Brightness can be controlled separately for each vector of a picture. A graphic display editor in FORTRAN IV for interactive editing and debugging of display files has been developed.     

Perception of American sign language in dynamic point-light displays

Perception of dynamic events of American Sign Language (ASL) was studied by isolating information about motion in the language from information about form. Four experiments utilized Johansson's technique for presenting biological motion as moving points of light. In the first, deaf signers were highly accurate in matching movements of lexical signs presented in point-light displays to those normally presented. Both discrimination accuracy and the pattern of errors were similar in this matching task to that obtained in a control condition in which the same signs were always represented normally. The second experiment showed that these results held for discrimination of morphological operations presented in point-light displays as well. In the third experiment, signers were able to accurately identify signs of a constant handshape and morphological operations acting on signs presented in point-light displays. Finally, in Experiment 4, we evaluated what aspects of the motion patterns carried most of the information for sign identifiability. We presented signs in point-light displays with certain lights removed and found that the movement of the fingertips, but not of any other pair of points, is necessary for sign identification and that, in general, the more distal the joint, the more information its movement carries.     

A two-year follow-up study of a preventive mental health program for preschoolers

The long-term effects of a preschool intervention program for high-risk experimental children were assessed and compared to a high-risk placebo control group and low-risk normal controls. Seventy first-grade children were involved in this 2-year follow-up. The experimental treatment group was superior to that of the placebo control group at follow-up on the criteria measures of behavioral adjustment and achievement. The low-risk normal control group was significantly different from that of the placebo control groups, but generally not significantly different from that of the experimental groups, suggesting that the intervention had boosted the high-risk experimental treatment children to the point where their performance was comparable to that of children who had not experienced behavioral or learning difficulties.The study was supported by grants from the McGregor Fund and the Eloise and Richard Webber Foundation, and by the Detroit Public Schools, for which the authors express grateful appreciation. A version of this paper was presented at the Annual Meeting of the American Psychological Association, New York, September 1979.     

The treatment of epilepsies with Convulsofin

The testing of Convulsofin carried out in 220 patients at 14 clinics over a period of six months confirms the international experience gained with valproic acid and sodium valproinate. The main field of application of Convulsofin according to the experience gained will again be the treatment of fits in generalised primary epilepsy for which it permits to carry out a monotherapy to a remarkable extent. The favourable effect of the preparation in photosensitivity could be confirmed. Also in generalised secondary epilepsy and in fits of partial epilepsy. Convulsofin is partly effective, so that it can recommended as a co-medication in the treatment of therapy-resistant forms of these epilepsies which are difficult to treat. Decrease in thrombocytes, transient increase in serum transaminases, gastrointestinal disorders, loss of hair and undesired increases in body-weight were the more frequently occurring side-effects.     

EDP (electronic data processing)-oriented special documentation in neurology--extension to a computer epicrisis

The contribution describes a final neurological documentation system for in-patients that permits the computerized print-out of an epicrisis. The computer automatically summarizes the elementary findings and presents them as a number of important neurological syndromes. The structure of the documentation and the experience gained in the course of many years of routine application are described. The system has proved to be basically sound under the conditions existing at a university hospital and a specialized hospital for psychiatry and neurology and has proved applicable for a large proportion of the patients without major restrictions.     

Conditioning of a discriminative drug stimulus: Overshadowing and blocking like procedures

Interactions between a drug discriminative stimulus ( D , 17.5 mg/kg of pentobarbital vs. N , saline) and exteroceptive stimulus conditions (light vs. dark) were examined in a T-maze, shock-escape task using conditioning procedures pertaining to the phenomena of "overshadowing" and "blocking". From an operational point of view, in the "overshadowing" procedure the stimulus compound is introduced from the outset of the training, whereas in the "blocking" procedure the stimuli components are introduced sequentially. When the compound discriminations were established, dose-generalization tests with various doses of pentobarbital (range 5.6–17.5 mg/kg) as well as saline (1 ml/kg) were carried out under both elements (light and dark) of the exteroceptive stimulus dimension. Prior training with drug ( D vs. N ) neutralized the potential influence of the exteroceptive dimension (light vs. dark); conversely training with the exteroceptive stimuli prior to the drug training accentuated the control over behavior by the visual stimuli. Dose-generalization results intermediate to those described above were observed in the group trained to discriminate the stimulus compound ( D plus light vs. N plus dark) from the outset of training. It may therefore be concluded that exteroceptive stimuli can compete with interoceptive drug stimuli for associative strength in the procedure used. Thus, the formal similarities between drug discriminative stimuli and more conventionally studied exteroceptive, sensory signals are furthered by the data.     

Hierarchical factor solution of coding and planning processes: Any new insights?

Hierarchical factor solution was used in the present paper in order to examine if two coding processes, simultaneous and successive, would load on a general 2nd level factor. It was further used to test if the coding processes and a factor representing planful behavior will not share the same general factor, revealing their relative independence as expected from a theoretical model of cognitive functions. Results supported the grouping of the coding tasks within a general factor, as well as the emergence of two general factors, one each for coding and planning. Further correlational evidence supported the relative independence of these two kinds of cognitive processes. These findings were discussed in the context of a general factor of intelligence.