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11.
Spatial learning and memory is preserved in rats after early development in a microgravity environment 总被引:1,自引:0,他引:1
This study evaluated the cognitive mapping abilities of rats that spent part of their early development in a microgravity environment. Litters of male and female Sprague-Dawley rat pups were launched into space aboard the National Aeronautics and Space Administration space shuttle Columbia on postnatal day 8 or 14 and remained in space for 16 days. These animals were designated as FLT groups. Two age-matched control groups remained on Earth: those in standard vivarium housing (VIV) and those in housing identical to that aboard the shuttle (AGC). On return to Earth, animals were tested in three different tasks that measure spatial learning ability, the Morris water maze (MWM), and a modified version of the radial arm maze (RAM). Animals were also tested in an open field apparatus to measure general activity and exploratory activity. Performance and search strategies were evaluated in each of these tasks using an automated tracking system. Despite the dramatic differences in early experience, there were remarkably few differences between the FLT groups and their Earth-bound controls in these tasks. FLT animals learned the MWM and RAM as quickly as did controls. Evaluation of search patterns suggested subtle differences in patterns of exploration and in the strategies used to solve the tasks during the first few days of testing, but these differences normalized rapidly. Together, these data suggest that development in an environment without gravity has minimal long-term impact on spatial learning and memory abilities. Any differences due to development in microgravity are quickly reversed after return to earth normal gravity. 相似文献
12.
William Meredith 《Psychometrika》1963,28(3):239-258
Criterion measures are frequently obtained by averaging ratings, but the number and kind of ratings available may differ from individual to individual. This raises issues as to the appropriateness of any single regression equation, about the relation of variance about regression to number and kind of criterion observations, and about the preferred estimate of regression parameters. It is shown that if criterion ratings all have the same true score the regression equation for predicting the average is independent of the number and kind of criterion scores averaged.Two cases are distinguished, one where criterion measures are assumed to have the same true score, and the other where criterion measures have the same magnitude of error of measurement as well. It is further shown that the variance about regression is a function of the number and kind of criterion ratings averaged, generally decreasing as the number of measures averaged increases. Maximum likelihood estimates for the regression parameters are derived for the two cases, assuming a joint normal distribution for predictors and criterion average within each subpopulation of persons for whom the same type of criterion average is available. 相似文献
13.
The tripartite model of anxiety and depression: symptom structure in depressive and hypertensive patient groups 总被引:2,自引:0,他引:2
Marshall GN Sherbourne CD Meredith LS Camp P Hays RD 《Journal of personality assessment》2003,80(2):139-153
The structure of self-reported symptoms representative of the tripartite model was examined using data drawn from the Medical Outcomes Study (Tarlov et al., 1989). Participants were persons who had been diagnosed 48 months previously as suffering from either depression (N = 315) or hypertension (N = 403). Results of confirmatory factor analyses were broadly consistent with the tripartite model (L. A. Clark & Watson, 1991). Factors emerged corresponding to each of the 3 posited first-order dimensions of negative affect, positive affect, and physiologic arousal. Nonetheless, some discrepancies were found between the observed data and the hypothesized tripartite model. First, the obtained physiologic arousal factor was best viewed as reflecting nonspecific somatic distress rather than physiologic arousal. Finally, although differentiable in the strictest statistical sense, all three domains were significantly correlated (.36 to.86, absolute value). In particular, contrary to the tripartite model, positive and negative affect covaried markedly (-.81 to -.86). Findings raise issues concerning the utility of the tripartite model as a heuristic framework for enhancing understanding of individual differences in normal mood as well as mood disorders. 相似文献
14.
Papadopoulos N McGinley J Tonge B Bradshaw J Saunders K Murphy A Rinehart N 《Autism》2012,16(6):627-640
The relationship of motor proficiency with emotional/behavioural disturbance, autistic symptoms and communication disturbance was investigated in children diagnosed with autism and Asperger's disorder (AD). The Movement Assessment Battery for Children was used as a measure of motor impairment, and the Developmental Behavioural Checklist was used as a measure of emotional/behavioural disturbance in the following groups: AD (n?=?22), high functioning autism (HFA) (n?=?23), LFA (n?=?8) and typically developing children (n?=?20). The HFA group had more difficulty with motor items, such as ball skills and balance, than did the AD group. There were significant positive correlations between impairments in motor proficiency (in particular ball skills and balance) and emotional/behavioural disturbance, autistic symptoms and communication disturbance. These findings are consistent with the hypothesis that there are qualitative and quantitative differences in the motor profile between autism and AD. In addition, the association between motor proficiency impairment and emotional/behavioural disturbance in autism and AD emphasizes the importance for screening of co-occurring emotional/behavioural symptoms in individuals with motor difficulties. These findings have implications for the potential use of adjunct motor measures in the diagnosis and definition of autism spectrum disorders. 相似文献
15.
Six pigeons key-pecked under a fixed-interval (FI) 3-min schedule of food presentation. Each pigeon was studied for 200 daily sessions with 15 intervals per session (3,000 total food presentations). Analyses included the examination of latency to first peck (pause), mean rate of key pecking, and ambulation. Characterizations of stable performance were assessed across measures of behavior and evaluated using commonly employed stability criteria. Stability of response rate and pause was identified better by assessments that evaluated variability and trend, rather than just variability. Between-subject differences in rate of acquisition and terminal values of steady-state performance of pause were observed, and stable pause durations took longer to develop than did stable key-pecking rates. Relative variability in response rate and pause duration decreased as the means increased. A temporally organized pattern of key-pecking (the so-called FI scallop) developed within 50 sessions of exposure to the schedule. Overall ambulation decreased during the early sessions of exposure and further analyses showed greater rates of ambulation during the pause than after it for 4 of the 6 pigeons. Performance under the FI 3-min schedule developed relatively slowly, and key-pecking, pause, and ambulation developed at different rates. 相似文献
16.
Despite its frequent use to assess effects of environmental and pharmacological variables on short-term memory, little is known about the development of delayed matching-to-sample (DMTS) performance. This study was designed to examine the dimensions and dynamics of DMTS performance development over a long period of exposure to provide a more secure foundation for assessing stability in future research. Six pigeons were exposed to a DMTS task with variable delays for 300 sessions (i.e., 18,000 total trials; 3,600 trials per retention interval). Percent-correct and log-d measures used to quantify the development of conditional stimulus control under the procedure generally and at each of five retention intervals (0, 2, 4, 8 and 16-s) individually revealed that high levels of accuracy developed relatively quickly under the shorter retention intervals, but increases in accuracy under the longer retention intervals sometimes were not observed until 100-150 sessions had passed, with some still increasing at Session 300. Analyses of errors suggested that retention intervals induced biases by shifting control from the sample stimulus to control by position, something that was predicted by observed response biases during initial training. These results suggest that although it may require a great deal of exposure to DMTS prior to obtaining asymptotic steady state, quantification of model parameters may help predict trends when extended exposure is not feasible. 相似文献
17.
Evidence suggests that parental marital discord contributes to the development of internalizing and externalizing symptoms
in children and adolescents. Few studies, however, have examined the association between parental marital discord and youth’s
response to treatment. The present study examined the impact of interparental discord on treatment response in a randomized
control trial of adolescents with major depression enrolled in the Treatment for Adolescents with Depression Study (TADS).
Participants were 260 adolescents from two-parent households randomly assigned to one of four treatment groups: fluoxetine
(FLX), cognitive behavior therapy (CBT), their combination (COMB), or placebo (PBO). Logistic regressions revealed that parental
marital discord interacted with youth gender and co-morbid oppositionality symptoms to predict group differences in treatment
response. 相似文献
18.
Zhang Jingchen Buchanan Gretchen J. R. Piehler Timothy F. Gunlicks-Stoessel Meredith Bloomquist Michael L. 《Journal of child and family studies》2022,31(9):2535-2544
Journal of Child and Family Studies - This study investigated the relation between parent–adolescent conflict and adolescents’ depressive symptoms from a dynamic systems framework. Two... 相似文献
19.
20.
Meredith P. Levsen Bruce D. Bartholow 《Cognitive, affective & behavioral neuroscience》2018,18(6):1283-1297
Affect regulation plays a key role in several theories of racial bias reduction. Here, we tested whether engaging in emotion regulation strategies while performing an implicit racial bias task (Weapons Identification Task; WIT) would alter neural and behavioral manifestations of bias. Participants either suppressed or reappraised in a positive light the distress associated with making errors during the WIT, while an electroencephalogram (EEG) was recorded. We hypothesized that engaging in emotion regulation strategies would reduce the distress associated with making errors indicative of bias, resulting in smaller error-related negativity (ERN) amplitude during errors and increased expression of racial bias. Results of within-subjects comparisons (Experiment 1) generally supported these predictions. However, when emotion regulation strategies were manipulated between subjects (Experiment 2) there was no effect of suppression or reappraisal on bias expression. Across both experiments, engaging in emotion regulation led to larger ERNs for errors occurring on Black- relative to White-primed trials. In addition, a number of significant order effects were observed, indicating important differences in the effects of engaging in emotion regulation strategies when those strategies are attempted in participants’ first versus second block of trials. No such order effects were evident when a second trial block was completed with no emotion regulation instructions. Findings are discussed in terms of the need for greater specificity in experimental tests of emotion regulation on error processing and cognitive performance. 相似文献