Discriminative stimulus effects of diazepam and buspirone in normal volunteers.

A within-subject design was used to characterize the effects of dose manipulations on discriminative and self-reported effects of oral diazepam and buspirone. Subjects were trained to discriminate diazepam (10 mg) versus placebo (n = 10), or buspirone (10 or 15 mg) versus placebo (n = 9). The compounds were identified to subjects by letter code before discrimination training began. In later sessions, correct identifications at 2 hr after the oral administration of drug earned money. All subjects showed accurate discrimination performance during the test-of-acquisition phase. In a low-dose generalization phase, diazepam and buspirone produced dose-related increases in drug identifications across a four-fold range of doses. In a subsequent low-dose training phase, in which subjects were trained to discriminate progressively lower drug doses, the median lowest discriminable dose of diazepam and buspirone was 2.5 and 7.5 mg, respectively. Dose-response functions for drug identifications were shifted leftward in the low-dose training phase relative to the low-dose generalization phase, suggesting that reinforcement of progressively lower doses enhances drug discriminability. The self-reported effects of diazepam and buspirone were similar (e.g., both drugs increased ratings of drug strength and clumsy/uncoordinated) and different (e.g., diazepam but not buspirone increased ratings of drowsy/sleepy; buspirone but not diazepam increased ratings of tense/nervous). This study demonstrates discriminative and self-reported effects of diazepam and buspirone at doses lower than previously shown to be behaviorally active, and suggests that at commonly used clinical doses, diazepam is relatively more discriminable than buspirone.     

Exploratory longitudinal factor analysis in multiple populations

For multiple populatios, a longtidinal factor analytic model which is entirely exploratory, that is, no explicit identification constraints, is proposed. Factorial collapse and period/practice effects are allowed. An invariant and/or stationary factor pattern is permitted. This model is formulated stochastically. To implement this model a stagewise EM algorithm is developed. Finally a numerical illustration utilizing Nesselroade and Baltes' data is presented.The authors wish to thank Barbara Mellers and Henry Kaiser for their helpful comments and John Nesselroade for providing us the data for our illustration. This research wwa supported in part by a grant (No. AG03164) from the National Institute on Aging to William Meredith. Details of the derivations and a copy of the PROC MATRIX program are available upon request from the first author.     

Segmenting global markets by generational cohorts: determining motivations by age

Marketing has long rested on the use of market segmentation. While birth age has been a useful way to create groups, it describes segments but in itself does not help to understand segment motivations. Environmental events experienced during one's coming‐of‐age years, however, create values that remain relatively unchanged throughout one's life. Such values provide a common bond for those in that age group, or cohort. Segmenting by ‘coming‐of‐age’ age provides a richer segmentation approach than birth age. This approach, known to work in America, is used in this paper to create generational cohorts in Russia and in Brazil. Copyright © 2004 Henry Stewart Publications Ltd.     

An examination of the impact of harsh parenting contexts on children's adaptation within an evolutionary framework

The current study tests whether propositions set forth in an evolutionary model of temperament (Korte, Koolhaas, Wingfield, & McEwen, 2005) may enhance our understanding of children's differential susceptibility to unsupportive and harsh caregiving practices. Guided by this model, we examined whether children's behavioral strategies for coping with threat and challenge cohered into 2 broad, phenotypic dimensions--hawk and dove--that have been maintained by frequency-dependent selection throughout our ancestral history: Hawk-like strategies are characterized by approach, dominant-negative affect, and activity, whereas dove-like strategies are evidenced by avoidance, inhibition, and vulnerable affect. In turn, we examined the moderating effect of hawk or dove profile membership on children's physiological and psychological adaptation to harsh rearing environments. Participants included 201 2-year-old toddlers and their mothers. Consistent with the Korte model, latent profile analyses extracted 2 profiles that cohered into hawk and dove strategies. Children were classified within hawk or dove profiles and separately examined in a process model of harsh caregiving. As predicted, associations between harsh caregiving practices and children's basal cortisol, parasympathetic nervous system, and sympathetic nervous system activity were moderated by profile membership. In turn, basal physiological levels were differentially predictive of children's psychological adaptation over time. Collectively, findings highlight the potential value of translating the study of evolutionary models to understanding developmental outcomes associated with harsh caregiving.     

Social anxiety and difficulty disengaging threat: evidence from eye-tracking

Theoretical models of social phobia propose that biased attention contributes to the maintenance of symptoms; however these theoretical models make opposing predictions. Specifically, whereas Rapee and Heimberg (1997) suggested the biases are characterised by hypervigilance to threat cues and difficulty disengaging attention from threat, Clark and Wells (1995) suggested that threat cues are largely avoided. Previous research has been limited by the almost exclusive reliance on behavioural response times to experimental tasks to provide an index of attentional biases. The current study evaluated the relationship between the time-course of attention and symptoms of social anxiety and depression. Forty-two young adults completed a dot-probe task with emotional faces while eye-movement data were collected. The results revealed that increased social anxiety was associated with attention to emotional (rather than neutral) faces over time as well as difficulty disengaging attention from angry expressions; some evidence was found for a relationship between heightened depressive symptoms and increased attention to fear faces.     

A Step in the Right Direction: Measuring Indicators of Responsible Community Engagement in Samburu,Kenya

Journal of Academic Ethics - The inclusion of stakeholders and knowledge systems is increasingly valued in research to address complex socio-ecological challenges around the world. Often these...     

Is it or isn’t it: Listeners make rapid use of prosody to infer speaker meanings

A visual world experiment examined the time course for pragmatic inferences derived from visual context and contrastive intonation contours. We used the construction It looks like an X pronounced with either (a) a H^* pitch accent on the final noun and a low boundary tone, or (b) a contrastive L + H^* pitch accent and a rising boundary tone, a contour that can support contrastive inference (e.g., It LOOKS_L+H*like a zebra_L-H%… (but it is not)). When the visual display contained a single related set of contrasting pictures (e.g. a zebra vs. a zebra-like animal), effects of LOOKS_L+H* emerged prior to the processing of phonemic information from the target noun. The results indicate that the prosodic processing is incremental and guided by contextually-supported expectations. Additional analyses ruled out explanations based on context-independent heuristics that might substitute for online computation of contrast.