Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice

Recent studies point to a major role for alpha2-containing GABA-A receptors in modulating anxiety. However, the possible implication of GABA-A receptors containing the alpha3 subunit on anxiety is less known. The aim of this study was to examine the effects of SB-205384 (0.5-4 mg/kg, i.p.), an alpha3 subunit positive modulator of GABA-A receptor, on anxiety tested in the elevated plus-maze in male mice, using classical and ethological parameters. Mice treated with SB-205384 showed an increase in the frequency of entries and the time spent in open arms, as well as a reduction in the time spent in closed arms, as compared with the control group. A notable increase of "head-dipping" unprotected and a reduction of "stretched-attend posture" protected was also evident. These findings indicate that SB-205384 exhibits an anxiolytic-like profile in the elevated plus-maze test, suggesting that GABA-A receptors which contain the alpha3 subunit might be involved in regulation of anxiety.     

The relationship between pre-treatment clinical profile and treatment outcome in an integrated stuttering program

A procedure for subtyping individuals who stutter and its relationship to treatment outcome is explored. Twenty-five adult participants of the Comprehensive Stuttering Program (CSP) were classified according to: (1) stuttering severity and (2) severity of negative emotions and cognitions associated with their speech problem. Speech characteristics (percentage of stuttered syllables, distorted speech score, and the number of correctly produced syllables on a diadochokinesis task) and emotional/cognitive states (emotional reaction, speech satisfaction, and attitudes toward speaking) were assessed before and after treatment, and at a 1- and 2-year follow-up. The results showed that: (a) there was no relationship between stuttering severity and the severity of negative emotions and cognitions, (b) the severe stuttering group had the largest treatment gains but also the highest level of regression, and (c) at post-treatment and both follow-up assessments the differences on measures of emotions between the mild and severe emotional group had disappeared, chiefly due to a large decrease in the latter group's negative emotions and cognitions. Our findings show that, based on treatment gains, specific subgroups can be identified, each requiring different treatment approaches. This underlines the necessity of developing a better understanding of how various dimensions of stuttering relate to treatment outcome. Educational objectives: The reader will be able to: (1) describe why stuttering severity and negative emotions and cognitions that are related to stuttering should be investigated separately and (2) describe how treatment outcome relates to subtypes of persons who stutter.     

Controllability and hindsight components: Understanding opposite hindsight biases for self-relevant negative event outcomes

There is an anomaly in the hindsight bias literature with respect to hindsight effects obtained after self-relevant negative event outcomes: Whereas some studies have reported reduced hindsight bias, others have shown increases. This article contrasts two explanations for the anomaly. The first points to an influence of perceived control over the event outcome: In hindsight, people decrease foreseeability (and hence, responsibility and blame) for controllable events, but they increase the perceived inevitability of uncontrollable events for coping reasons. The second explanation, derived from a reconception of hindsight bias in terms of separate components (Blank, Nestler, von Collani, & Fischer, 2008), traces the anomaly to differences in the observed hindsight components: Hindsight decreases are to be expected for foreseeability, whereas increases are restricted to the inevitability component. Our experiment (N=210) manipulated controllability and the hindsight component orthogonally and showed strong support for the component explanation, but also some influence of perceived control.     

Opening What Has Been Closed,Relaxing What Has Been Clenched: Dissociation and Enactment Over Time in Committed Relationships

I use dissociation and the concept of the multiple self to link Mitchell's profound insight with Goldner's critique. In the process, I use the idea of dissociation to think about the nature of different kinds of long-term relationships.     

A Method for the Evaluation of Affective Associations to Figure Drawings

Usual scoring systems for figure drawing techniques are based on structural and content aspects of the drawing, and ignore the affectively toned associations that occur when an observer first sees a drawing. A system for measuring two components of judgment, (a) emission of affective associations (b) evaluation of affective associations, has been developed. This method was applied with some success in studying individuals who had represented in their drawings an image that corresponded to their actual physical appearance. The research so far suggests that the evaluation component of judgment may contribute more to discrimination than the emission component.     

Mental Health and Adverse Childhood Experiences

The theoretical basis of occupational therapy interventions was investigated in two mental health facilities in the Midwestern United States. Using retrospective cohort and grounded theory designs, 121 medical records were reviewed and five occupational therapy practitioners were interviewed. Theoretical reasoning was not explicitly documented, but according to analysis, the behavioral/cognitive-behavioral model, client-centered models, and the model of human occupation were the most frequently used theories to guide interventions. Lack of documentation of theory use has significant implications for the value accorded to occupational therapy skills in health care. A larger study is recommended to increase external generalizability of the findings.     

Developing Roles and Skills in Community-Living Adults With Severe and Persistent Mental Illness

People with severe and persistent mental illness often experience a disruption in the development of social roles, and the skills within these roles. Role Development, a set of guidelines for practice, is an intervention to develop roles and skills. The purpose of this study was to continue to examine the efficacy of this intervention. Ten people attending two community mental health programs participated in evaluation and treatment based on Role Development. Quantitative pretest and posttest measures were used. Qualitative components were incorporated to get a sense of the experience involved in developing roles and skills. Quantitative results indicated statistical significance (p < .05) in the development of roles and skills. Qualitative data revealed multiple trends experienced by the participants. This study contributes to the evidenced-based knowledge regarding development of roles and skills for persons living with severe and persistent mental illness.     

Understanding the Transition from Career to Fulltime Motherhood: A Qualitative Study

According to the literature, minimal research has been conducted on fulltime mothers (i.e., stay-at-home mothers [SAHM]); studies dealing with motherhood tend to emphasize the developmental needs of the child versus the mother. The current research seeks to tackle that issue by bringing fulltime motherhood to the forefront. In particular, phenomena related to women transitioning from work to fulltime motherhood are qualitatively examined. Four women participated in this study and shared their personal experiences surrounding this subject matter. A SAHM Model and two SAHM Portraits are created to comprehend and explain the complexities found within their roles.     

Adquisición y evaluación de las funciones pragmáticas del lenguaje: un estudio evolutivo

Resumen

El progresivo interés de los teóricos de la adquisición lingüística en el componente pragmático del lenguaje ha dado pie a la elaboración, en los últimos años, de numerosos índices de medida y taxonomías de clasificación útiles para analizar el uso funcional que del lenguaje hace el niño en los tres primeros años de vida. Aplicando un sistema de análisis propuesto por Ph. Dale (1980) a conductas de carácter comunicativo obtenidas a través de sistemas de elicitación (en tareas estructuradas) y de producción verbal libre (en situación de juego), se revisan en este trabajo algunos aspectos relacionados con la adquisición de las funciones pragmáticas y con la metodología de este tipo de estudios.