Effects of SB-205384, a positive modulator of alpha3-subunit-containing GABA-A receptors, on isolation-induced aggression in male mice

GABA-A receptors are involved in the control of aggressive behaviour. Various studies suggest a role for a1-containing GABA-A receptors in modulating aggression. However, the possible involvement of a3 subunit of GABA-A receptors has not been examined. In this study, we analysed the effect of SB-205384 (0.5-4 mg/kg, i.p), a positive modulator of GABA-A receptors containing a3 subunit, on agonistic behaviour elicited by isolation in male mice. Half of the mice were housed during 30 days and employed as experimental or control animals; the remainder were used as and were temporally rendered anosmic by zinc sulphate. Individually housed mice were exposed to anosmic opponents in a neutral area 30 minutes after the drug administration and encounters were videotaped and evaluated using an ethopharmacologically-based analysis. The results indicated that SB-205384 did not produce any significant behavioural changes, suggesting that GABA-A receptors which contain the a3 subunit may not be involved in the modulation of aggression.     

Parenting styles

Parental educational styles constitute one of the key elements of family socialization. The aim of the present essay is to present the results of a research project carried out in the Principality of Asturias (Spain) among 2,965 families with children of infant and primary-school age (5-8 years old). This research attempts to analyse, among other aspects, parental behaviour tendencies in child upbringing. The analysis of the results obtained allows us to: 1) identify the most common attitudinal and behavioural tendencies of parents in the upbringing of their children; 2) determine how many people have a well defined parental style, and delimit their socio-educational characteristics. Lastly, we consider the need to change some parental behaviour patterns and stress the importance of family education programmes, with the aim of promoting appropriate parenting models and modifying or improving current practices.     

Functions of the pointing gesture in mothers and their 12 to 36-month-old children during everyday activities

This study longitudinally examined the production of pointing in four Spanish 1-year-old and four Spanish 2-year-old children in interactive situations with their mothers at home over the course of one year. Three aspects were analyzed: a) the functions of the pointing gesture, their accurate comprehension by the interlocutor (mother or child), and their order of emergence in the child; b) whether or not there were differences in the production of pointing according to who initiated the interaction; and c) whether maternal and child speech were related to maternal and child pointing production. The results showed that the pointing function of showing is the most frequent for both children and mothers from groups 1 and 2, and the first to emerge followed by the informing, requesting object, requesting action, and requesting cooperation functions. The accuracy with which these intentions were comprehended was found to be very high for both mother and child. Pointing production was greater when the speaker initiated the interaction than when the other person did, indicating that gestures follow the turn-taking system. Finally, the production of pointing to showing in children and mothers was found to be related to maternal and child speech, while pointing to request cooperation triggered the process of joint activity between mother and child.     

The role of the anterior left hemisphere in real-time sentence comprehension: evidence from split intransitivity

We investigate Broca's sentence comprehension as an impairment on normal syntactic composition: the slow-syntax hypothesis (SSH). Experiment 1 examines comprehension of object-relative clauses (Wh-movement). Experiment 2 examines comprehension of sentences with unaccusative verbs (NP-movement), which like passives, base-generate their theme-argument in object position. Guided by the SSH, both experiments test the prediction that syntax-dependent effects such as "gap-filling" are observable but in a delayed fashion. Results show that whereas no priming was obtained at the point of the trace, antecedent reactivation emerged 650 and 800 ms after the verb (for Wh- and NP-movement respectively). This shows, contrary to dependency-based generalizations, that Broca's patients are able to successfully implement dependencies, albeit in a protracted manner. Given the localization value provided by Broca's aphasia, this supports the notion that the temporal implementation of syntactic structure formation (i.e., the requirement that it be fast and automatic) depends on the integrity of the anterior left hemisphere.     

Altering the timing of academic prompts to treat destructive behavior maintained by escape

Following a functional analysis showing that destructive behavior was reinforced by escape, we altered the aversiveness of task demands by interspersing easy and difficult tasks and by presenting a corrective prompt as an antecedent event the next time a previously failed item was presented; this procedure was compared with one in which the corrective prompt was provided as an immediate consequence. Results of a reversal design showed that the antecedent prompt acted as an establishing operation and reduced destructive behavior to zero.     

What Differences Do They See? Using Mixed Methods to Capture Adolescent Perceptions of Neighborhood Contexts

Recent neighborhood research emphasizes the importance of individuals’ perceptions of their neighborhoods, as well as expands the definition of “neighborhood” to include the different contexts encountered during routine daily activities (Coulton et al., 2013; Kwan, 2012). The present study uses qualitative interviews, sketch mapping, and survey data to explore adolescents’ experiences of different neighborhoods within their activity space. Participants included 55 racially diverse youth aged 11–19 (M = 14.64, SD = 2.33) who resided in low-income neighborhoods in a small city in the Midwest. The majority reported spending time in multiple self-defined neighborhoods, noting significant differences between neighborhoods on collective efficacy, street code, and on participant-generated dimensions. Self-defined neighborhoods did not correspond to Census tracts, and Census indicators were not associated with youth's perceptions (e.g., collective efficacy, street code). Youth spent time in neighborhoods that differed significantly on multiple Census indicators of structural disadvantage, though within-individual differences tended to be small in magnitude. Type of routine activity was largely not predictive of distance traveled from home, though some findings suggest youth were more likely to cross neighborhood boundaries to engage in structured activities compared to different unstructured activities. Implications for neighborhood research and interventions are discussed.     

Reliability and sources of validity evidence of the Oviedo Schizotypy Assessment Questionnaire-Abbreviated (ESQUIZO-Q-A)

The main goal of this research was to examine the reliability and different sources of validity evidence of the Oviedo Schizotypy Assessment Questionnaire-Abbreviated (ESQUIZO-Q-A) in nonclinical adolescents. The final sample was made up of 1,455 participants, 705 males (48.5%), with a mean age of 15.92 years (SD = 1.18). The internal consistency of the subscales ranged from .62 to .75. The analysis of its internal structure yielded a three-dimensional solution based on the dimensions: Reality Distortion, Anhedonia, and Interpersonal Disorganization. Likewise, the goodness-of-fit indices derived from the Confirmatory Factor Analysis for the hypothesized three-factor model were adequate. The three dimensions of the ESQUIZO-Q-A were significantly correlated with the subscales of the Strengths and Difficulties Questionnaire. The ESQUIZO-Q is a brief and simple self-report with adequate psychometric properties for the assessment of schizotypal traits in nonclinical adolescent populations. Future research should continue to explore the metric quality of the ESQUIZO-Q-A (e.g., sensitivity and specificity) and incorporate the new advances in psychological and educational assessment such as Computerized Adaptive Testing.     

Phenotypic expression of schizotypal traits in an adolescent population

The main goal of the present study was to examine the influence of gender and age in the phenotypic expression of schizotypal traits in a community sample of adolescents. The sample was composed of a total of 1,618 participants, 776 (48%) males, with a mean age of 15.9 years (SD = 1.2). The ESQUIZO-Q: Oviedo Schizotypy Assessment Questionnaire was used for the assessment of schizotypal traits, a measure specifically developed for its use in adolescents. The results showed that gender and age were two sociodemographical variables that influenced the expression of schizotypal features. The males in the study obtained higher mean scores than the females in the Negative dimension (Physical and Social Anhedonia); however, the females obtained higher mean scores in Magical Thinking, Lack of Close Friends, and Social Disorganization. With regard to age, the younger adolescents had lower scores in Odd Thinking and Language, Lack of Close Friends, Excessive Social Anxiety, and Social Disorganization compared to the older adolescents. This differential pattern is similar to the one found in patients with schizophrenia and in nonclinical young adults, and these findings improve our understanding about the phenotypic expression of schizotypy during adolescence.     

Quality of Life in Women Following Various Surgeries of Body Manipulation: Organ Transplantation, Mastectomy, and Breast Reconstruction

This study aimed to determine biopsychosocial differences (anxious-depressive symptomatology and quality of life) among three groups of patients who underwent surgical interventions related to body manipulation, as well as to assess the clinical significance of these results versus reference values. Four groups were compared: women who underwent organ transplant (n = 26), mastectomy for breast cancer (n = 36), breast reconstruction (n = 36), and general population (n = 608). The Hospital Anxiety and Depression Scale and the EORTC QLQ-C30 were used. Women who underwent mastectomy showed the highest anxious-depressive symptomatology and quality-of-life impairment in comparison to the remaining groups, and they also displayed the most clinically significant deterioration in the majority of dimensions (large effect sizes). In contrast, the group with implantation of a healthy organ (transplantation) only showed higher biopsychosocial impairment than the group with reconstruction of an organ (breast reconstruction) in gastrointestinal dysfunctions and in the global self-perception of health.     

Cognitive Factors in Fibromyalgia: The Role of Self-Concept and Identity Related Conflicts

Fibromyalgia is a syndrome characterized by the presence of diffuse and chronic musculoskeletal pain of unknown etiology. Clinical diagnosis and the merely palliative treatments considerably affect the patient's experience and the chronic course of the disease. Therefore, several authors have emphasized the need to explore issues related to self in these patients. The repertory grid technique (RGT), derived from personal construct theory, is a method designed to assess the patient's construction of self and others. A group of women with fibromyalgia (n = 30) and a control group (n = 30) were assessed using RGT. Women with fibromyalgia also completed the Fibromyalgia Impact Questionnaire and a visual-analogue scale for pain, and painful tender points were explored. Results suggest that these women had a higher present self–ideal self discrepancy and a lower perceived adequacy of others, and it was more likely to find implicative dilemmas among them compared to controls. These dilemmas are a type of cognitive conflict in which the symptom is construed as “enmeshed” with positive characteristics of the self. Finally, implications of these results for the psychological treatment of fibromyalgia are suggested to give a more central role to self-identity issues and to the related cognitive conflicts.