Validation of a Chinese Version of the Obsessive Beliefs Questionnaire

Cognitive models of obsessive-compulsive disorder (OCD) assign a central role to maladaptive beliefs. Evaluation of these OCD beliefs in Western countries is commonly accomplished using the Obsessive Beliefs Questionnaire (OBQ) and is important for conceptualizing and treating OCD. It remains unclear if Western models of OCD beliefs are appropriate for sufferers in some non-Western regions, such as China, which represents nearly 20 % of the world population. Thus, the aim of present study is to examine the psychometric properties of a Chinese translation of the OBQ in three samples: 1,322 undergraduates, 139 patients with OCD, and 79 patients with other anxiety disorders. Confirmatory factor analysis revealed poor fit for multiple English-based models of the OBQ. However, an exploratory factor analysis supported an OBQ model that differs slightly from the English version: (1) Perfectionism/Certainty (P/C), (2) Over-Estimation of Threat (T), (3) Importance of Thoughts/Responsibility for Harm (I/R). This Chinese version of the OBQ (C-OBQ) contains 30 items and shows adequate internal consistency, test-retest reliability, construct validity, and criterion-related validity. In China, the C-OBQ may be a useful instrument for delineating cognitive patterns associated with OCD to inform research and treatment.     

糖皮质激素治疗脓毒血症的策略

脓毒症是由感染所致的破坏性的全身炎症反应综合征,进一步发展可导致多器官功能障碍综合征,甚至休克,成为危重患者最主要的死亡原因之一。糖皮质激素是脓毒症的重要辅助药物,其治疗机制在于其抑制机体的炎症反应,但其使用剂量、疗程、时间一直存在争议。本文通过回顾糖皮质激素在治疗脓毒症的发展历程,深入探讨糖皮质激素治疗脓毒血症的治疗策略。     

Maternal supplementation of nucleotides improves the behavioral development of prenatal ethanol-exposed mice

Maternal ethanol consumption during pregnancy can induce learning deficits in the offspring. The objective of this study was to assess whether supplementation of exogenous nucleotides during pregnancy and lactation would ameliorate prenatal ethanol-induced learning and memory deficits in the offspring of mice, and to explore the possible mechanisms. In the present study, pregnant C57BL/6J mice were exposed to ethanol (5 g/kg body weight) intragastrically from gestational day (GD) 6 to GD15. The dams in exogenous nucleotide intervention groups were fed with feed containing 0.01 %, 0.04 %, or 0.16 % nucleotide powder, with control and ethanol groups receiving normal feed. The dams were allowed to deliver naturally and to breast feed their offspring. After weaning, behavioral tests were carried out in the offspring of each group. Serum oxidation indexes were analyzed, and the hippocampus of each offspring was collected and detected for acetyl cholinesterase (AChE) activity and the expression of p-CREB, CREB, and BDNF. The results showed that maternal supplementation with exogenous nucleotides during pregnancy could ameliorate prenatal ethanol-induced learning and memory deficits in the offspring of mice, through improving their antioxidant capacity, reversing hippocampus AChE levels, and allowing the expression of some proteins related to learning and memory. However, different sensitivities were found between the two sexes.     

Momentary Return of the Cosmic Unconscious: The Nature of Zen/Chan Enlightenment

Zen/Chan, which used to be a Far Eastern philosophy-cum-religion, has evolved into a global cultural phenomenon. Despite the many views expressed by numerous thinkers in the world, the consensus on Chan and Chan enlightenment remains an agnostic Oriental mysticism. By exploring Chan and enlightenment from a combined perspective of history, philosophy, psychology, religion and linguistics, this article proposes a hitherto unexpressed view. Chan enlightenment is a prenatal physico-psychological existence, which grows out of a fetal subject’s perception of the womb. Although this primordial mode of perception is unconscious, it is cosmic in nature because for the fetal subject the womb is the whole world with which it feels to be at one. This unconscious oneness may be termed the ‘cosmic unconscious’. Once born, no one can return to the prenatal mental state, but through personal cultivation and Chan practice one can experience a fleeting moment of the cosmic unconscious. In the final analysis, the essence of Chan enlightenment is a momentary return of the cosmic unconscious. It is, therefore, not a great wisdom which enables one to have a profound understanding of the self and the world, but a non-wisdom induced by a return to the prenatal primal being of life.     

安宁疗护中社会支持相关理论的研究进展

阐述了福利多元论、社会支持论、社会角色论和社会网络论的起源、内涵、理论研究和实践的现状,旨在为构建更加完善的社会支持系统提供理论参考依据,以进一步提高安宁疗护服务质量。四种理论对构建社会支持系统的视角不同、结论不同,对社会支持实践指导意义亦各有差别。此外,虽然不同理论各有侧重,但仍不乏共同之处。我国安宁疗护社会支持系统发展不充分、不完善,因此在借鉴不同理论的同时,既应求同存异,又要博采众长,才能构建适应我国国情和区域发展实际的安宁疗护社会支持系统。     

科学发明情境中问题提出的脑机制再探

以高生态学效度的科学发明问题情境作为实验材料,采用静息态功能磁共振成像技术,基于低频振幅(ALFF)和静息态功能连接(RSFC)的分析方法,探讨创造性科学问题提出的脑机制。结果发现,在控制了被试性别、年龄后,提出新颖有效性问题的比率越高,左内侧前额叶(Left media prefrontal cortex,L-mPFC)和右小脑前叶(Right cerebellum)的ALFF值越高。进一步功能连接分析发现,提出新颖有效性问题的比率与mPFC和楔叶(Cuneus)之间的功能连接强度呈显著正相关。结果强调mPFC对于科学发明情境中问题提出的重要作用,且更高比率的新颖有效性问题的提出是通过mPFC与其它脑区的协同联结来实现的。     

以新型农村合作医疗为平台 加强农村妇幼保健工作

住院分娩是否应该纳入新型农村合作医疗的补偿范围,目前在学术界和实践中仍然存在争议。以陕西省镇安县为案例,从公共政策分析的角度,通过对该县定额住院分娩制度运行效果的分析,论证了把住院分娩纳入合作医疗补偿范围的积极意义,同时针对该制度运行过程中出现的问题提出了相应的政策建议。     

空性的三方会谈

空性是宇宙的根本实相,佛学、老子、量子论各依自身的需要和目的分别进行了阐述。其三方的结论具有一定的可比性及哲学上的相似性。由此说明了她们对宇宙根本实相的认识具有深刻的统一性。     

The Relationship Between Family Stress and Behavioral Health Among African American Adolescents

African American youth, especially those who live in low-income communities, are at increased risk for experiencing higher juvenile justice involvement, poorer mental health, low school engagement, higher illicit drug use, and STIs, relative to their higher income peers and those from other ethnic backgrounds. However, few studies have examined the relationship between family stressors and these multiple youth concerns. This study examines the relationship between family stress (i.e., having an adult in the home with a history of mental illness, substance use, and incarceration) and youth concerns such as substance use, mental health challenges, low school engagement, juvenile justice involvement, and STI risk behaviors. A total of 638 African American adolescents living in predominantly low-income, urban communities participated in the study by completing self-report measures on the above constructs. Logistic regressions controlling for age, gender, socioeconomic status, and sexual orientation indicated that adolescents who reported higher rates of family stress were significantly more likely to report mental health problems, delinquent behaviors, juvenile justice involvement, drug use, risky sex, and lower school engagement factors. Findings suggest that attending to the developmental concerns of youth also requires addressing the needs of the family unit.