非小细胞肺癌靶向药物治疗争论热点

非小细胞肺癌作为全球和我国发病率最高、死亡人数最多的恶性肿瘤,其药物治疗始终是临床肿瘤学界高度关注的焦点之一.肿瘤的药物治疗模式从单纯以细胞毒药物杀伤肿瘤逐步向调节信号传导通路转变,分子靶向药物日益成为治疗肿瘤的重要武器.回顾肺癌靶向治疗的进展,诸多问题需要解决.     

Performance,cardiovascular, and health behavior effects of an inhibitory strength training intervention

Female undergraduates were assigned to one of three groups, two involving regulatory training and one not. Training participants performed for 2 weeks tasks that required strong behavioral restraint (Strong Training) or weak behavioral restraint (Weak Training). Later, they took part in (1) a laboratory session in which they performed tasks with inhibitory components, and (2) a follow-up week in which they provided health behavior reports and used designated dental supplies. No Training participants took part only in the session and follow-up week. As expected, laboratory performance was improved for Strong- relative to No Training participants, with performance for Weak Training participants falling in between. Also as expected, Strong Training participants used more floss in the follow-up week than did the No Training participants, with floss for Weak Training participants falling between. Contrary to expectation, Strong Training participants used less toothpaste and reported having brushed less than the No Training participants. In addition, Strong Training participants evinced exaggerated—rather than diminished—cardiovascular responses during the laboratory tasks. The performance and floss use data support the suggestion that inhibitory system strength can be increased through use. The brushing and cardiovascular findings may be interpretable in inhibitory strength terms.     

“100% of anything looks good”: The appeal of one hundred percent

People overweight certainty, even when certainty is only an illusion. A vaccine that was described as 100% effective against 70% of disease targets was preferred to one described as 70% effective against 100% of disease targets (Studies 1 and 2). The appeal of 100% extends beyond the probability attribute. In Study 2, participants preferred both of the vaccines above to normatively equivalent vaccines that were less than 100% effective toward fewer than 100% of targets. In Study 3, participants preferred a 100% discount on a cup of coffee every 10 days to other more frequent, but lower amount, discounts. This preference evaporated, however, when savings were framed as points rather than as percentage discounts. We propose that people view 100% as a salient reference point and overweight it in those domains where it cannot be exceeded (e.g., probability, discount); the overweighting is weaker in domains where 100% can be exceeded (e.g., target range, points).     

Measuring subjective well-being: A comparison of China and the USA

In this article the structure of subjective well-being (SWB), the relationship between household income and SWB and mean differences in components of SWB in China and the USA are investigated. Both China and the USA were characterized in a three-factor model of SWB (life satisfaction, positive affect and negative affect). Household income was more strongly positively correlated with the three major components of SWB in China than in the USA. Lower levels of SWB were generally reported by participants in China than in the USA; however, there were mean differences in different regions of China.     

记忆的知觉干扰效应研究概述

知觉干扰效应是指在识记阶段快速呈现一个单词,紧接着给予一个倒行掩蔽的刺激,在随后的记忆测验中被试表现出对单词的记忆增强的一种现象。知觉干扰效应的影响因素分为测验方式、实验设计方式、实验材料的属性和其他影响因素四个方面。理论解释主要有六种：精细加工假说、时空背景假说、任务要求假说、补偿加工假说、选择性复述假说以及项目特异关联假说。最后,文章从研究领域和实验材料的拓展以及主观因素的影响展望了该研究领域     

自我和他人的协调与心理理论的神经机制

有关心理理论神经机制的研究远未达到共识。从自我与他人协调的角度看,可认为它是一个由多脑区有机组织而成的系统。自我中心化偏差是人类认知的一种默认选择,要正确理解他人的心理状态,需要抑制自我中心偏差。因此,心理理论的加工至少包括以下几个不同的过程：通过模拟自我理解他人,相应的加工脑区为镜像神经元系统;从他人与客体形成的二元关系中表征心理状态的内容,相应脑区是颞顶联合区;对模拟自我进行抑制,相应脑区为背外侧额叶;以及整合协调以上几个过程,其脑区可能是内侧前额叶     

竞技运动中自我控制的逆效应

自我控制的逆效应是指在高压力下,在进行努力地自我控制的过程中产了与意愿相反的心理状态的现象。文章介绍了逆加工理论的双过程模型,评论了与竞技运动相关的动作控制、情绪控制、消极表象抑制、放松和集中注意的心理控制的逆加工效应研究,并指出竞技运动中自我控制的逆加工效应研究存在三方面的局限：缺乏生态学效度、心理控制的逆效应的测量不够客观和应对策略研究不足,未来的研究应该在这三个方面有所改进     

项目组合在结构方程模型中的应用

项目组合（itemparceling）是对同一量表中的若干项目进行整合并形成新的观测指标的过程。虽然一直以来它都是一个有争议的议题,但随着其在结构方程模型中的应用日益广泛,它越来越受到研究者重视。文章从项目组合的基本逻辑、优缺点以及具体方法等方面对项目组合的研究进行了概括,并在此基础上提出了使用的具体建议：（1）根据研究的目的与具体情境选择是否需要组合;（2）组合之前必须首先确定概念的维度性;（3）项目组合最好建立在一定的理论基础上等等。未来的研究可以深入探讨各种组合方法对模型拟合以及参数估计的影响以及项目组合在一些SEM高阶应用中的效果,并进一步与项目反应理论等测量理论相结合     

反语认知的神经-心理机制研究及其进展

反语是指使用与本意相反的语句表达本意的修辞形式.从脑损伤者和神经发展异常者(包括精神分裂症和孤独症患者)角度,介绍了反语认知神经心理机制的研究,评述了现有研究并指出未来研究的方向.     

Communal Behaviors and Psychological Adjustment of Family Caregivers and Persons With Spinal Cord Injury

OBJECTIVE: Examined the influence of mutual communal behaviors on the adjustment reported by persons with spinal cord injury (SCI) and their family caregivers. Previous research has found that persons who have a history of mutually communal behaviors in relationships may react differently to relationship changes after an acquired physical disability than dyads with few communal behaviors. METHOD: Family caregivers and persons with SCI were administered measures of mutual communal behaviors, depression, and life satisfaction. Structural equation modeling was used to test the relations among caregivers' communal behaviors and care recipients' communal behaviors, depression, and life satisfaction. RESULTS: Caregiver and care recipient reports of communal behaviors were not significantly correlated. Significant paths indicated that care recipients' communal behavior scores were positively associated with their life satisfaction, and care recipients' depression was inversely associated with their life satisfaction. Caregivers' communal behavior scores were unrelated to their self-reported adjustment. CONCLUSIONS: Caregiver-care recipient dyads may differ in their perceptions of communal behaviors in their relationships. Although care recipient reports of communal behavior may be related to their life satisfaction, communal behaviors may not serve a similar function among caregivers of persons with SCI.