Substance P at the nexus of mind and body in chronic inflammation and affective disorders

For decades, research has demonstrated that chronic diseases characterized by dysregulation of inflammation are particularly susceptible to exacerbation by stress and emotion. Likewise, rates of depression and anxiety are overrepresented in individuals suffering from chronic inflammatory disease. In recent years, substance P has been implicated in both the pathophysiology of inflammatory disease and the pathophysiology of depression and anxiety by 2 parallel fields of study. This review integrates the literature from these 2 parallel fields and examines the possibility that substance P dysregulation may be a point of convergence underlying the overlap of chronic inflammatory disease and mood and anxiety disorders. First, the involvement of substance P in peripheral inflammation and in the immune events associated with chronic inflammatory disease is discussed, with a focus on inflammatory bowel disease and asthma. Next, the function of substance P in the communication of peripheral inflammation to the brain is considered. Finally, to complete the bidirectional loop of brain-immune interactions, substance P expression in anxiety and depression as well as its potential role in the neural regulation of peripheral inflammation is reviewed.     

On the automatic evaluation of end-states

The author's research examined automatically activated attitudes toward desired end-states. Across 4 studies, participants' automatic attitudes toward goals (i.e., thinness, egalitarianism) significantly predicted their goal pursuit, including behaviors, intentions, and judgments. Such attitudes predicted behavior and judgments that are difficult to monitor and control (i.e., restrained eating, subtle prejudice), but not judgments that are easy to monitor and control (i.e., blatant prejudice). Automatic attitudes toward goals also possessed unique predictive validity compared with explicit measures of motivation and with automatic attitudes toward more physical, "graspable" objects. The findings are discussed with regard to the predictive validity of automatic attitudes, the use of automatic attitudes toward goals as an implicit measure of motivation, and the role of automatic evaluative processes in goal-pursuit and self-regulation.     

The use of PowerPoint shareware for making Jeopardy!--type games in the teaching of psychology

We describe the use of readily available templates to create a Jeopardy!--type game using PowerPoint slides suitable for psychology courses. The templates can accommodate information from any psychology class and can easily be used to incorporate languages other than English. A major limitation of the templates is that they are only available as shareware on internet sites and the links to such sites can be unreliable. To avoid this problem we present our own template. Differences between the shareware and our own program are noted, as are ways to use the game to stimulate interest in psychology.     

The roles of encoding,retrieval, and awareness

In the experiment reported here, we examined the processes by which expected (probable) changes are detected more frequently than are unexpected (improbable) changes (the change probability effect; Beck, Angelone, & Levin, 2004). The change probability effect may be caused by a bias toward probable changes during encoding of the prechange aspect, during retrieval of the prechange aspect, or during activation of an explicit response to the change. Participants performed a change detection task for probable and improbable changes while their eye movements were tracked. Change detection performance was superior for probable changes, but long-term memory performance was equivalent for both probable and improbable changes. Therefore, although both probable and improbable prechange aspects were encoded, probable prechange aspects were more likely to be retrieved during change detection. Implicit change detection was also greater for probable changes than for improbable changes, suggesting that the change probability effect is the result of a bias during the retrieval and comparison stage of change detection. The stimuli used in the change detection task may be downloaded from www.psychonomic.org/archive.     

Integration of impulsivity and positive mood to predict risky behavior: development and validation of a measure of positive urgency

In 3 studies, the authors developed and began to validate a measure of the propensity to act rashly in response to positive affective states (positive urgency). In Study 1, they developed a content-valid 14-item scale, showed that the measure was unidimensional, and showed that positive urgency was distinct from impulsivity-like constructs identified in 2 models of impulsive behavior. In Study 2, they showed that positive urgency explained variance in risky behavior not explained by measures of other impulsivity-like constructs, differentially explained positive mood-based risky behavior, differentiated individuals at risk for problem gambling from those not at risk, and interacted with drinking motives and expectancies as predicted to explain problem drinking behavior. In Study 3, they confirmed the hypothesis that positive urgency differentiated alcoholics from both eating-disordered and control individuals.     

Familial Association and Frequency of Learning Disabilities in ADHD Sibling Pair Families

In a sample of 235 families with at least two children with Attention-Deficit/ Hyperactivity Disorder (ADHD), the frequency and familial association of learning disabilities (LD) were assessed. Familiality was examined both between sibling pairs and between parents and their children. Two methods for defining LD, a discrepancy-based and a low-achievement model, were employed to examine the occurrence of LD in this sample. The specific types of LD examined included Reading Disability (RD), Math Disability (MD), and Writing Disability (WD). The prevalence rates were highest for RD, followed by WD then MD. The two definitions of LD yielded similar prevalence rates but identified different groups of children with vastly different IQ scores. Strong familial association was demonstrated for RD both between sibling pairs and between parents and children, with weaker association for WD. There was evidence of nonrandom mating for LD among parents, but not for ADHD or for ADHD + LD. Despite the high comorbidity of ADHD and LD among parents, the presence of ADHD in the parents did not predict child LD supporting independent familial factors underlying ADHD and LD.     

An open trial of cognitive therapy for chronic insomnia

We describe the development of a cognitive therapy intervention for chronic insomnia. The therapy is based on a cognitive model which suggests that the processes that maintain insomnia include: (1) worry and rumination, (2) attentional bias and monitoring for sleep-related threat, (3) unhelpful beliefs about sleep, (4) misperception of sleep and daytime deficits and (5) the use of safety behaviors that maintain unhelpful beliefs. The aim of cognitive therapy for insomnia is to reverse all five maintaining processes during both the night and the day. In an open trial 19 patients meeting diagnostic criteria for primary insomnia were treated with cognitive therapy for insomnia. Assessments were completed pretreatment, posttreatment and at 3-, 6- and 12-month followup. The significant improvement in both nighttime and daytime impairment evident at the posttreatment assessment was retained up to the 12 month followup.     

Effects of normal aging on memory for multiple contextual features

Twenty-four younger (18-35 years) and 24 older adult participants (65 or older) were exposed to three experimental conditions involving the memorization words and their associated contextual features, with contextual feature complexity increasing from Conditions 1 to 3. In Condition 1, words presented varied only on one binary feature (color, size, or character), while in Conditions 2 and 3, words presented varied on two and three binary features, respectively. Each condition was carried out as follows: (1) learning of a word list; (2) encoding of words and their contextual features; (3) delay; and (4) memory for contextual features through a discrimination task. Results indicated that young adults discriminated more features than older adults on all conditions. In both age groups, contextual feature discrimination accuracy decreased as the number of features increased. Moreover, older adults demonstrated near floor performance when tested with two or more binary features. We conclude that increasing context complexity strains attentional resources.     

Gender-specific Normative Misperceptions of Risky Sexual Behavior and Alcohol-related Risky Sexual Behavior

This research examined gender-specific perceptions of risky sexual behavior norms among college students and their relationship with one’s own sexual behavior. We expected that students would misperceive the risky sexual behavior of their peers and that these perceptions would positively relate to their sexual behavior. Undergraduate students from the United States (N?=?687; 57.6% female) completed measures assessing perceived sexual behavior, sexual behavior, and other behaviors (e.g., marijuana use, alcohol consumption). Findings demonstrated that students perceived that others engaged in more risky sexual behavior than they do and that perceived norms were positively associated with one’s own behavior. The incorporation of personalized normative feedback regarding risky sexual behavior into brief interventions aimed at reducing risky sexual behavior is discussed.