Impact of Genomic Counseling on Informed Decision-Making among ostensibly Healthy Individuals Seeking Personal Genome Sequencing: the HealthSeq Project

Personal genome sequencing is increasingly utilized by healthy individuals for predispositional screening and other applications. However, little is known about the impact of ‘genomic counseling’ on informed decision-making in this context. Our primary aim was to compare measures of participants’ informed decision-making before and after genomic counseling in the HealthSeq project, a longitudinal cohort study of individuals receiving personal results from whole genome sequencing (WGS). Our secondary aims were to assess the impact of the counseling on WGS knowledge and concerns, and to explore participants’ satisfaction with the counseling. Questionnaires were administered to participants (n = 35) before and after their pre-test genomic counseling appointment. Informed decision-making was measured using the Decisional Conflict Scale (DCS) and the Satisfaction with Decision Scale (SDS). DCS scores decreased after genomic counseling (mean: 11.34 before vs. 5.94 after; z = ?4.34, p < 0.001, r = 0.52), and SDS scores increased (mean: 27.91 vs. 29.06 respectively; z = 2.91, p = 0.004, r = 0.35). Satisfaction with counseling was high (mean (SD) = 26.91 (2.68), on a scale where 6 = low and 30 = high satisfaction). HealthSeq participants felt that their decision regarding receiving personal results from WGS was more informed after genomic counseling. Further research comparing the impact of different genomic counseling models is needed.     

Conceptual Integration of Arithmetic Operations With Real‐World Knowledge: Evidence From Event‐Related Potentials

Research on language processing has shown that the disruption of conceptual integration gives rise to specific patterns of event‐related brain potentials (ERPs)—N400 and P600 effects. Here, we report similar ERP effects when adults performed cross‐domain conceptual integration of analogous semantic and mathematical relations. In a problem‐solving task, when participants generated labeled answers to semantically aligned and misaligned arithmetic problems (e.g., 6 roses + 2 tulips  = ? vs. 6 roses + 2 vases  = ?), the second object label in misaligned problems yielded an N400 effect for addition (but not division) problems. In a verification task, when participants judged arithmetically correct but semantically misaligned problem sentences to be “unacceptable,” the second object label in misaligned sentences elicited a P600 effect. Thus, depending on task constraints, misaligned problems can show either of two ERP signatures of conceptual disruption. These results show that well‐educated adults can integrate mathematical and semantic relations on the rapid timescale of within‐domain ERP effects by a process akin to analogical mapping.     

Posttraumatic Growth and HIV: A Study on Associations of Stigma and Social Support

The present study investigated the influence of HIV‐related stigma and social support on posttraumatic growth (PTG) in adults with HIV (N = 126). The study examined if social support moderated the relationship between stigma and PTG. Results from the study revealed that the predictor variables contributed significantly to PTG following an HIV diagnosis; however, no significant interaction effect between the 2 variables was found. Implications for counselors and directions for future research are provided.     

Gender attitudes, feminist identity, and body images among college women

Cultural forces influence body-image development in gender-contingent ways, such that women in our society possess more dysfunctional body-image attitudes than men do. However, few studies have examined how women’s body-image experiences relate to their own gender attitudes and ideologies. This investigation of 122 college women assessed multiple parameters of body image (i.e., evaluation, investment, and affect) and different facets of gender attitudes and feminist identity development. Results revealed minimal relationships between body-image attitudes and either feminist identity or adherence to traditional gender beliefs at individual/stereotypic or societal levels. On the other hand, traditional gender attitudes at the level of male-female social interactions were associated with stronger and more dysfunctional investments in cultural and personal appearance standards. The scientific, social, and clinical implications of these findings are discussed.     

Left Syringeal Dominance in Testosterone-Treated Female Canaries

Male canaries (Serinus canaria) produce most of their song syllable types on the left side of the syrinx, the two-sided vocal organ. Female canaries treated with testosterone propionate begin to sing in a male fashion, a behavior seldom seen in untreated females. To learn whether syringeal dominance occurs in testosterone-treated female canaries, we deactivated either the right or the left side of the syrinx by severing the tracheosyringeal nerve on that side. Recordings of the birds’ songs were made before and after the nerve cut, and song analysis was based upon visual comparisons of sound spectrograms. Pre- and post-operative syllable types were identified by their frequency structures and repetition rates. Six of eight birds displayed clear left dominance as assessed by nerve cuts; therefore, we concluded that most, but not all, female canaries generate the majority of their syllable types with the left syrinx.     

Memoirs of a drug-abusing prostitute: Dynamics and treatment considerations in a case of intergenerational child abuse

This paper examines the dynamics of a 26-year-old prostitute who entered psychotherapy with a number of symptoms. The patient had undergone a series of traumas in her life and was reenacting them in her present behavior. Repetition compulsion, as described by Freud, was a primary form of resistance manifested by this patient. The repetition of the sexual trauma reenacted itself in her choice of profession; namely, prostitution. Additionally, this woman had lived her early years falsely believing that her parents were caring for her, when in fact, they were her grandparents. This early family secret led to the development of a false self within the patient, as well as a strong sense of entitlement, greed, and need for revenge.