If We Build It … Will They Come? – Establishing a Cancer Genetics Services Clinic for an Underserved Predominantly Latina Cohort

Background: Cancer genetic counseling and testing is a standard of care option for appropriate families and can identify individuals at increased risk prior to diagnosis, when prevention or detection strategies are most effective. Despite documented efficacy of cancer risk reduction in high-risk individuals, underserved and minority individuals have a disproportionate cancer burden and limited access to genetic counseling. Methods: A needs assessment survey documented gaps in knowledge and interest in prevention. Satellite clinics were established at two indigent healthcare systems. Cancer genetics CME lectures were conducted and referral guidelines disseminated to clinicians who referred patients for counseling. Results: An increase in clinician knowledge was demonstrated post-CME and reflected by quality referrals. Eighty-eight percent of patients kept their appointments. In the predominantly Latina⁶ (n=77) clinic population, 71.4% were affected with cancer, and 17 mutation positive families were identified. Preliminary data shows a positive impact on patients' motivation and behavior. The majority has expressed satisfaction and reduction in anxiety. Conclusions: This study demonstrates feasibility and acceptability of cancer genetics services in this population, suggesting the potential to reduce cancer morbidity in underserved, high-risk families.“Latino” is the most common census term for individuals of Spanish, Mexican, Central and South American, Cuban, or Puerto Rican descent, referring to ethnicity, and is generally considered a more ethnically/culturally based term for individuals of the aforementioned groups. As this cohort is female the feminine noun “Latina” is used     

Dear diary, is plastic better than paper? I can't remember: Comment on Green, Rafaeli, Bolger, Shrout, and Reis (2006)

In this commentary, the authors discuss the implications of A. S. Green, E. Rafaeli, N. Bolger, P. E. Shrout, and H. T. Reis's (2006) diary studies with respect to memory. Researchers must take 2 issues into account when determining whether paper-and-pencil or handheld electronic diaries gather more trustworthy data. The first issue is a matter of prospective memory, and the second is a matter of reconstructive memory. The authors review the research on these issues and conclude that regardless of the type of diary researchers use, several factors can conspire to produce prompt--but inaccurate--data.     

Human and Animal Subjects of Research: The Moral Significance of Respect versus Welfare

Human beings with diminished decision-making capacities are usually thought to require greater protections from the potential harms of research than fully autonomous persons. Animal subjects of research receive lesser protections than any human beings regardless of decision-making capacity. Paradoxically, however, it is precisely animals’ lack of some characteristic human capacities that is commonly invoked to justify using them for human purposes. In other words, for humans lesser capacities correspond to greater protections but for animals the opposite is true. Without explicit justification, it is not clear why or whether this should be the case. Ethics regulations guiding human subject research include principles such as respect for persons—and related duties—that are required as a matter of justice while regulations guiding animal subject research attend only to highly circumscribed considerations of welfare. Further, the regulations guiding research on animals discount any consideration of animal welfare relative to comparable human welfare. This paper explores two of the most promising justifications for these differences␣between the two sets of regulations. The first potential justification points to lesser moral status for animals on the basis of their lesser capacities. The second potential justification relies on a claim about the permissibility of moral partiality as␣found in common morality. While neither potential justification is sufficient to justify the regulatory difference as it stands, there is possible common ground between supporters of some regulatory difference and those rejecting the current difference.     

Gender, socioeconomic status, age, and jealousy: emotional responses to infidelity in a national sample

The authors used a representative national sample (N = 777) to test the evolutionary hypothesis that men would be more bothered by sexual infidelity and women by emotional infidelity, the Jealousy as a Specific Innate Module (JSIM) effect. Our alternative conceptualization of jealousy suggests that there are distinct emotional components of jealousy that did not evolve differently by gender. The authors looked for effects of age, socioeconomic status (SES), and type of measure (continuous or dichotomous) on jealousy. The authors did not find age or SES effects. Forced-choice items provided support for our alternative view; both genders showed more anger and blame over sexual infidelity but more hurt feelings over emotional infidelity. Continuous measures indicated more emotional response to sexual than emotional infidelity among both genders.     

Will Julia Roberts harm Nicole Kidman? Semantic priming effects during face naming

Three experiments are reported, which examine whether face naming is vulnerable to semantic competition in a similar way to object naming. Previous experiments with object naming have shown that a related prime picture presented 3 trials before a target picture results in an increase in error rate and naming latencies when compared to unrelated prime conditions. The experiments here use the same paradigm, with errors as the main dependent variable. In Experiment 1, the prime and target faces were from the same occupational category (e.g., politicians, actors), and in Experiment 2, the primes and target faces were also associated to each other. In Experiment 3, the prime was presented as a name to be read aloud. Unrelated filler stimuli intervened between prime and target. In all experiments, there was a reduction in target-naming errors in the related conditions, and in Experiment 3 this was shown to be largely a reduction in naming failures. The results suggest that related name representations for famous people are not activated in parallel and in competition, and that there is some evidence for a relatively long lasting facilitatory effect. These results require some modification to any serial account of face naming to differentiate it from the generally well-established serial account of object naming.     

Hedonic and sensory characteristics of odors conditioned by pairing with tastants in humans

Animals readily acquire positive odor-taste hedonic associations, but evidence for this in humans remains weak and was explored further. Retronasal pairing of odors with sucrose or salty stimuli (Experiment 1) increased the rated sweetness of sucrose-paired odors without altering liking, although changes in odor pleasantness correlated with sucrose liking. Experience of odors with sucrose or quinine by sweet likers (Experiment 2) found increased pleasantness and sweetness for sucrose-paired odors, whereas quinine-paired odors became less liked and more bitter. Odor-sucrose pairings in sweet likers and dislikers (Experiment 3) found increased sweetness in both groups but increased odor liking only in likers. These data suggest that evaluative and sensory learning are dissociable and that evaluative changes are sensitive to individual differences in sweet liking.     

Phonetic-semantic mediated false recognition: does activation fail to spread?

Spoken word recognition involves brief activation of candidate words. Six experiments examined whether words semantically related to phonologically activated words would be falsely recognized. Experiments 1 and 2 involved homophones as test words; Experiment 3 used strong associates for the semantic mediation link. Experiment 4 approximated lists of "strong" converging associates. Experiment 5 expanded the real time needed for word identification by using a gating procedure during study. In Experiment 6, the goal was to create a more sensitive test by requiring participants to indicate which of two lures (mediated or control) was "most likely" to be new. Recognition errors were sensitive to separate phonetic and semantic stages in the mediated chain; however, there was little evidence of mediated false recognition, despite expectations derived from common models of spreading activation.     

The control of saccade trajectories: direction of curvature depends on prior knowledge of target location and saccade latency

Recent reports have shown that saccades can deviate either toward or away from distractors. However, the specific conditions responsible for the change in initial saccade direction are not known. One possibility, examined here, is that the direction of curvature (toward or away from distractors) reflects preparatory tuning of the oculomotor system when the location of the target and distractor are known in advance. This was investigated by examining saccade trajectories under predictable and unpredictable target conditions. In Experiment 1, the targets and the distractors appeared unpredictably, whereas in Experiment 2 an arrow cue presented at fixation indicated the location of the forthcoming target prior to stimulus onset. Saccades were made to targets on the horizontal, vertical, and principal oblique axis, and distractors appeared simultaneously at an adjacent location (a separation of +/- 45 degrees of visual angle). On average, saccade trajectories curved toward distractors when target locations were unpredictable and curved away from distractors when target locations were known in advance. There was no overall difference in mean saccade latencies between the two experiments. The magnitude of the distractor modulation of saccade trajectory (either toward or away from) was comparable across the different saccade directions (horizontal, vertical, and oblique). These results are interpreted in terms of the time course of competitive interactions operating in the neural structures involved in the suppression of distractors and the selection of a saccade target. A relatively slow mechanism that inhibits movements to distractors produces curvature away from the distractor. This mechanism has more time to operate when target location is predictable, increasing the likelihood that the saccade trajectory will deviate away from the distractor.     

Disgust vulnerability and symptoms of contamination-based OCD: descriptive tests of incremental specificity

The present investigation examines the incremental association between disgust propensity and sensitivity and contamination-based obsessive-compulsive disorder (OCD) symptoms. Structural equation modeling in Study 1 indicated that general disgust was related to contamination fear even when controlling for negative affect in a nonclinical sample. Evidence was also found for a model in which the effect of negative affect on contamination fear is mediated by general disgust. Study 1 also showed that both disgust sensitivity and disgust propensity uniquely predicted contamination fear when controlling for negative affect. Growth curve analyses in Study 2 indicated that higher baseline contamination fear is associated with less reduction in contamination fear over a 6-week period as disgust sensitivity increases even when controlling for negative affect. Lastly, disgust propensity was associated with concurrent levels of excessive washing symptoms among patients with OCD in Study 3 when controlling for depression. Implications of these findings from nonclinical, analogue, and clinical samples for future research on the specificity of disgust-related vulnerabilities in the etiology of contamination concerns in OCD are discussed.