The effect of flumazenil on acquisition, retention, and retrieval of spatial information.

The effect of flumazenil, a benzodiazepine-receptor antagonist, was evaluated in a spatial-reference memory procedure in a water maze. Flumazenil (1.0, 3.0, and 10.0 mg/kg, ip) did not modify acquisition of spatial information. Retention was similar between control and experimental rats 24 h after the training phase, as all groups showed bias to the target quadrant in a free swim trial. However, 10 days later, only flumazenil-injected rats (3.0 mg/kg) showed bias to the target quadrant. Flumazenil did not affect retrieval of spatial information in a group of well-trained rats. These results suggest that a benzodiazepine-receptor mediated endogenous mechanism is activated during learning of spatial tasks and that its blockade facilitates retention of spatial information.     

mTOR signaling in the hippocampus is necessary for memory formation

It is widely accepted that the formation of long-term memory (LTM) requires mRNA translation, but little is known about the cellular mechanisms in the brain that regulate this process. Mammalian target of rapamycin (mTOR) is a key regulator of translational efficacy and capacity. Here, we show that LTM formation of one-trial inhibitory avoidance (IA) in rats, a hippocampus-dependent fear-motivated learning task, requires mTOR activation. IA training is specifically associated with a rapid increase in the phosphorylation state of mTOR and its substrate ribosomal S6 kinase (p70S6K). Bilateral intra-CA1 infusion of rapamycin, a selective mTOR inhibitor, 15 min before, but not immediately after training completely hinders IA LTM without affecting short-term memory (STM) retention. Therefore, our findings indicate that the regulation of hippocampal mRNA translation is a major control step in memory consolidation.     

Miller (1944) revisited: Movement times in relation to approach and avoidance conflicts

Three experiments (total N = 291) sought to provide support for the idea that avoidance conflicts, relative to approach conflicts, are more difficult to motorically resolve. Conflicts were instantiated by asking individuals to approach desirable stimuli and avoid undesirable stimuli under conditions in which there was no objectively-correct direction of movement. To control for baseline movement speeds, non-conflict trials presented desirable (e.g., reward) and undesirable (e.g., threat) stimuli in the absence of any spatial conflict. In addition, movement times were isolated through the use of a joystick movement paradigm in which movement speeds were quantified subsequent to some initial tendency to move in one direction or the other. Consistent with hypotheses, all experiments found that movement times were slowed in the context of avoidance conflicts relative to approach conflicts. Results are discussed in terms of theories of motivation, affective processing, conflict, and anxiety.     

Snitching versus reporting: A qualitative analysis of barriers and facilitators to addressing safety concerns among high school students

Social Psychology of Education - Creating effective school-wide safety mechanisms depends on understanding students' previous experiences of reporting, however, students may also be...     

Do Women Accommodate More Than Men? Gender Differences in Perceived Social Support and Negotiation Behavior by Spanish and Dutch Worker Representatives

Historically, the role of worker representatives (WRs) is traditionally perceived as masculine. With an increasing participation of women in the workforce, the number of female WRs grows all over Europe. WRs’ main task is to negotiate on behalf of the constituency. We explore how male and female WRs perceive support from their constituency and how this perceived support is related to their negotiation behavior. We test hypotheses about the impact of gender and societal culture on perceived support and accommodating behavior in negotiations. The hypotheses are tested using a quantitative approach among 219 female and 495 male WRs in Spain and 166 female and 398 male WRs in the Netherlands. Following the research question there was no evidence indicating gender differences in accommodating behavior. Results show that a) WRs accommodate less to management in Spain than in the Netherlands; b) female WRs perceive less social support than their male counterparts in Spain, but not in the Netherlands; c) social support is negatively related to accommodating behavior only for female WRs in Spain, but not in the Netherlands. We discuss theoretical and practical implications.     

Threat ≠ prevention,challenge ≠ promotion: The impact of threat,challenge and regulatory focus on attention to negative stimuli

The purpose of the current experiment was to distinguish between the impact of strategic and affective forms of gain- and loss-related motivational states on the attention to negative stimuli. On the basis of the counter-regulation principle and regulatory focus theory, we predicted that individuals would attend more to negative than to neutral stimuli in a prevention focus and when experiencing challenge, but not in a promotion focus and under threat. In one experiment (N = 88) promotion, prevention, threat, or challenge states were activated through a memory task, and a subsequent dot probe task was administered. As predicted, those in the prevention focus and challenge conditions had an attentional bias towards negative words, but those in promotion and threat conditions did not. These findings provide support for the idea that strategic mindsets (e.g., regulatory focus) and hot emotional states (e.g., threat vs. challenge) differently affect the processing of affective stimuli.