Brain dopamine and kinematics of graphomotor functions

Three experiments were performed in an attempt to achieve a better understanding of the effect of dopamine on handwriting. In the first experiment, kinematic aspects of handwriting movements were compared between healthy participants and patients with Parkinson's disease (PD) on their usual dopaminergic treatment and following withdrawal of dopaminergic medication. In the second experiment, the writing performance of healthy participants with a hyperechogenicity of the substantia nigra as detected by transcranial sonography (TCS) was compared with the performance of healthy participants with low echogenicity of the substantia nigra. The third experiment examined the effect of central dopamine reduction on kinematic aspects of handwriting movements in healthy adults using acute phenylalanine and tyrosine depletion (APTD). A digitising tablet was used for the assessment of handwriting movements. Participants were asked to perform a simple writing task. Movement time, distance, velocity, acceleration and measures of fluency of handwriting movements were measured. The kinematic analysis of handwriting movements revealed that alterations of central dopaminergic neurotransmission adversely affect movement execution during handwriting. In comparison to the automatic processing of handwriting movements displayed by control participants, participants with an altered dopaminergic neurotransmission shifted from an automatic to a controlled processing of movement execution. Central dopamine appears to be of particular importance with regard to the automatic execution of well-learned movements.     

What does the analyst want? Free association in relation to the analyst’s activity, ambition, and technical innovation

The author traces the history of free association, the "fundamental rule," through the Freud-Ferenczi relationship and controversy. The use of "activity," first proposed by Freud in 1910 with phobic and compulsive patients, was then championed by Ferenczi in the early twenties. The goal of activity was to enhance-or, more accurately, "to force"--the associations into the analysis. Subsequently, Ferenczi reversed himself, concluding that his analysis was re-creating the traumatic parental environment which originally caused the patient's neurosis. The far-reaching results of Ferenczi's change of heart included a redefinition of countertransference and added the techniques of "indulgence" and "relaxation" to soften Freud's emphasis on "abstinence" and "frustration. A vignette from the analysis of a dangerously self-destructive bulimic patient illustrates the value of free association in helping a patient feel understood by the analyst without pressure to give up her symptoms. Constantly monitoring his therapeutic ambition, the analyst demonstrates the value of free association in enhancing the patient's understanding of herself and of the survival value of her symptoms. This vignette highlights the fact that the analyst's therapeutic ambition makes freedom to associate even more difficult for the patient and inevitably intrudes on the analyst's evenly hovering attention. Of course for the analyst to have a therapeutic wish is necessary and desirable but for the analyst to demand change promotes compliance and hidden rebellion which limits the analysis.     

Processing abstract sequence structure: learning without knowing, or knowing without learning?

Constant interaction with a dynamic environment—from riding a bicycle to segmenting speech—makes sensitivity to the sequential structure of the world a fundamental dimension of information processing. Accounts of sequence learning vary widely, with some authors arguing that parsing and segmentation processes are central, and others proposing that sequence learning involves mere memorization. In this paper, we argue that sequence knowledge is essentially statistical in nature, and that sequence learning involves simple associative prediction mechanisms. We focus on a choice reaction situation introduced by Lee (1997), in which participants were exposed to material that follows a single abstract rule, namely that stimuli are selected randomly, but never appear more than once in a legal sequence. Perhaps surprisingly, people can learn this rule very well. Or can they? We offer a conceptual replication of the original finding, but a very different interpretation of the results, as well as simulation work that makes it clear how highly abstract dimensions of the stimulus material can in fact be learned based on elementary associative mechanisms. We conclude that, when relevant, memory is optimized to facilitate responding to events that have not occurred recently, and that sequence learning in general always involves sensitivity to repetition distance.     

Consciousness: converging insights from connectionist modeling and neuroscience

Over the past decade, many findings in cognitive neuroscience have resulted in the view that selective attention, working memory and cognitive control involve competition between widely distributed representations. This competition is biased by top-down projections (notably from prefrontal cortex), which can selectively enhance some representations over others. This view has now been implemented in several connectionist models. In this review, we emphasize the relevance of these models to understanding consciousness. Interestingly, the models we review have striking similarities to others directly aimed at implementing 'global workspace theory'. All of these models embody a fundamental principle that has been used in many connectionist models over the past twenty years: global constraint satisfaction.     

Age-related differences in familiarity and recollection: ERP evidence from a recognition memory study in children and young adults

Using event-related potentials (ERPs), we examined the relative contributions of familiarity and recollection to recognition memory for items and their study contexts in school-aged children and adults. Whereas adults were able to selectively accept target items and to reject familiar nontarget items in an exclusion task, this discrimination was more difficult for children, as was evident in the high false alarm rates to nontargets even when item memory was controlled for. The analysis of the adults’ ERPs revealed more flexible and task-appropriate retrieval mechanisms, as was evident in the correlates of familiarity, recollection, and nontarget retrieval, as well as in postretrieval evaluation. In contrast, children’s ERPs revealed a parietal old/new effect for targets taken as a putative correlate of recollection. These findings suggest that children rely predominantly on recollection during recognition judgments, even in the absence of efficient memory control processes. The latter processes enable adults to monitor and verify the retrieved information and to control nontarget retrieval in the service of adequate source memory performance.     

Learning versus behavioral expression of the learned: The effects of a secondary tone-counting task on implicit learning in the serial reaction task

The replicated finding that implicit learning in the serial reaction task (SRT) is impaired when both the learning and the assessment of learning occur in the presence of a secondary tone-counting task has been interpreted as implying that the mechanism(s) underlying implicit sequence learning require(s) attention in order to operate. However, in almost all studies, learning and the assessment of learning have been confounded. It is therefore unclear whether tone counting affects learning per se, the behavioral expression of the learned, or both. The goal of the present research was to disentangle the effects of tone counting on learning and the expression of the learned. In Exps. 1a and 1b, participants performed the Nissen and Bullemer SRT under different single-task (ST) and dual-task (DT) practice schedules. In Exps. 2a and 2b, participants received different amounts of ST and DT practice. In all experiments, degree of implicit learning was then assessed under both ST and DT conditions. Results are consistent with the argument that primarily the expression of what has been learned and, to some extent, implicit learning itself, are affected by tone counting. These findings are easily understood in terms of specific interference mechanisms but are problematic for models that contain the assumption of an attentional learning mechanism. Received: 16 October 1996 / Accepted: 5 February 1997     

A template-matching pandemonium recognizes unconstrained handwritten characters with high accuracy

Psychological data suggest that internal representations such as mental images can be used as templates in visual pattern recognition. But computational studies suggest that traditional template matching is insufficient for high-accuracy recognition of real-life patterns such as handwritten characters. Here we explore a model for visual pattern recognition that combines a template-matching and a feature-analysis approach: Character classification is based on weighted evidence from a number of analyzers (demons), each of which computes the degree of match between the input character and a stored template (a copy of a previously presented character). The template-matching pandemonium was trained to recognize totally unconstrained handwritten digits. With a mean of 37 templates per type of digit, the system has attained a recognition rate of 95.3%, which falls short of human performance by only 2%–3%.     

GPOWER: A general power analysis program

GPOWER is a completely interactive, menu-driven program for IBM-compatible and Apple Macintosh personal computers. It performs high-precision statistical power analyses for the most common statistical tests in behavioral research, that is,t tests,F tests, andχ ² tests. GPOWER computes (1) power values for given sample sizes, effect sizes andα levels (post hoc power analyses); (2) sample sizes for given effect sizes,α levels, and power values (a priori power analyses); and (3)α andβ values for given sample sizes, effect sizes, andβ/α ratios (compromise power analyses). The program may be used to display graphically the relation between any two of the relevant variables, and it offers the opportunity to compute the effect size measures from basic parameters defining the alternative hypothesis. This article delineates reasons for the development of GPOWER and describes the program’s capabilities and handling.     

Neural correlates of temporal auditory processing in developmental dyslexia during German vowel length discrimination: an fMRI study

This fMRI study investigated phonological vs. auditory temporal processing in developmental dyslexia by means of a German vowel length discrimination paradigm (Groth, Lachmann, Riecker, Muthmann, & Steinbrink, 2011). Behavioral and fMRI data were collected from dyslexics and controls while performing same-different judgments of vowel duration in two experimental conditions. In the temporal, but not in the phonological condition, hemodynamic brain activation was observed bilaterally within the anterior insular cortices in both groups and within the left inferior frontal gyrus (IFG) in controls, indicating that the left IFG and the anterior insular cortices are part of a neural network involved in temporal auditory processing. Group subtraction analyses did not demonstrate significant effects. However, in a subgroup analysis, participants performing low in the temporal condition (all dyslexic) showed decreased activation of the insular cortices and the left IFG, suggesting that this processing network might form the neural basis of temporal auditory processing deficits in dyslexia.