L-type voltage-gated calcium channels in conditioned fear: a genetic and pharmacological analysis

Using pharmacological approaches, others have suggested that L-type voltage-gated calcium channels (L-VGCCs) mediate both consolidation and extinction of conditioned fear. In the absence of L-VGCC isoform-specific antagonists, we have begun to investigate the subtype-specific role of LVGCCs in consolidation and extinction of conditioned fear using a molecular genetics approach. Previously, we used this approach to demonstrate that the Ca(v)1.3 isoform mediates consolidation, but not extinction, of contextually conditioned fear. Here, we used mice in which the gene for the L-VGCC pore-forming subunit Ca(v)1.2 was conditionally deleted in forebrain excitatory neurons (Ca(v)1.2(cKO) mice) to address the role of Ca(v)1.2 in consolidation and extinction of conditioned fear. We demonstrate that Ca(v)1.2(cKO) mice consolidate and extinguish conditioned fear as well as control littermates. These data suggest that Ca(v)1.2 is not critical for these processes and together with our previous data argue against a role for either of the brain-expressed L-VGCCs (Ca(v)1.2 or Ca(v)1.3) in extinction of conditioned fear. Additionally, we present data demonstrating that the L-VGCC antagonist nifedipine, which has been used in previous conditioned fear extinction studies, impairs locomotion, and induces an aversive state. We further demonstrate that this aversive state can enter into associations with conditioned stimuli that are present at the time that it is experienced, suggesting that previous studies using nifedipine were likely confounded by drug toxicity. Taken together, our genetic and pharmacological data argue against a role for Ca(v)1.2 in consolidation of conditioned fear as well as a role for L-VGCCs in extinction of conditioned fear.     

Conditional forebrain deletion of the L-type calcium channel Ca V 1.2 disrupts remote spatial memories in mice

To determine whether L-type voltage-gated calcium channels (L-VGCCs) are required for remote memory consolidation, we generated conditional knockout mice in which the L-VGCC isoform Ca(V)1.2 was postnatally deleted in the hippocampus and cortex. In the Morris water maze, both Ca(V)1.2 conditional knockout mice (Ca(V)1.2(cKO)) and control littermates displayed a marked decrease in escape latencies and performed equally well on probe trials administered during training. In distinct contrast to their performance during training, Ca(V)1.2(cKO) mice exhibited significant impairments in spatial memory when examined 30 d after training, suggesting that Ca(V)1.2 plays a critical role in consolidation of remote spatial memories.     

Parenting and Emerging Adult Internalizing Problems: Regional Differences Suggest Southern Parenting Factor

Although the effects of parenting styles have received much consideration in the research literature, less attention has been given to outcomes in emerging adults. Also, regional differences among areas of the United States may influence parents to use varying degrees of parenting practices such as affection and discipline. The current study investigated the differences in parenting in two geographically close yet distinct regions of the United States and the associated psychological outcomes in emerging adults. The sample was derived from two datasets: one consisting of participants predominantly from Southern states and one predominantly from Florida. The participants reported on maternal and paternal perceived parenting styles and discipline tactics as well as their own internalizing problems. Most notably, authoritative style of both parents shared a direct relationship with authoritarian style in the Southern sample, whereas this was an inverse relationship in the Florida sample. Maternal authoritarian parenting shared a negative relationship with internalizing symptoms in the Mississippi sample, whereas this relationship was positive in the Florida sample. Additionally, paternal permissive parenting shared a negative relationship with internalizing symptoms in the Florida sample, whereas no relationship was found in the Mississippi sample. For both samples, paternal, not maternal, corporal punishment and maternal, not paternal, psychological aggression were related positively to emerging adult internalizing problems. Overall, it was found that both parenting characteristics as well as associated outcomes differed by region, suggesting the need for increased awareness and sensitivity to these differences.     

The effect of arbitration program characteristics on applicants' intentions toward potential employers

The authors examined intentions toward prospective employers with different alternative dispute resolution (ADR) policies and no ADR policy. In Study 1, students (N = 124) were randomly assigned to 1 of 4 conditions in which 2 variables, arbitration policy presence or absence and firm desirability, were manipulated. The presence of a voluntary, nonbinding arbitration policy had no impact on intentions and did not interact with firm desirability. In Study 2, students (N = 273) were randomly assigned to 1 of 8 conditions (mandatory vs. voluntary arbitration, binding vs. nonbinding arbitration, and highly desirable vs. less desirable employer). Both mandatory and binding arbitration policies were related to less favorable intentions toward firms. Predictions regarding the interaction of ADR policy and firm desirability were partially supported. Some support was found for the interaction between ADR policy and ethnicity.