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11.
There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.  相似文献   
12.
Pigeons were trained to peck a key on a variable-interval 2-min schedule of food reinforcement. Prior to each session, either 2.0 mg/kg methadone (n = 3), 3.0 mg/kg cocaine (n = 4), or 5.6 mg/kg cocaine (n = 2) was administered. When each pigeon's rate of pecking was stable, a range of doses of the training drug and saline were administered prior to 20-min extinction sessions separated by at least four training sessions. Rate of pecking during these extinction tests was generally an increasing function of dose, with the lowest rates obtained following saline and low doses and the highest rates obtained following doses near the training doses. Dose functions from pigeons trained with 5.6 mg/kg cocaine were steeper than those from pigeons trained with 3.0 mg/kg cocaine. Pigeons trained with methadone or 3.0 mg/kg cocaine were then given discrimination training, in which food reinforcement followed drug administration and 20-min extinction sessions followed saline administration. Rates of pecking under these conditions quickly diverged until near-zero rates were obtained following saline and high rates were obtained following drug. Discrimination training steepened dose functions for the training drugs, and the effects of several other substituted drugs depended on the pharmacology of the training drug. The pigeons trained with 5.6 mg/kg cocaine were tested with d-amphetamine, methadone, and morphine prior to discrimination training. d-Amphetamine increased rates dose dependently, and methadone and morphine did not. The results suggest that discriminative control by methadone and cocaine was established without explicit discrimination training.  相似文献   
13.
An expression is given for weighted least squares estimators of oblique common factors, constrained to have the same covariance matrix as the factors they estimate. It is shown that if as in exploratory factor analysis, the common factors are obtained by oblique transformation from the Lawley-Rao basis, the constrained estimators are given by the same transformation. Finally a proof of uniqueness is given.The research reported in this paper was partly supported by Natural Sciences and Engineering Research Council Grant No. A6346.  相似文献   
14.
In general, nonlinear models such as those commonly employed for the analysis of covariance structures, are not globally identifiable. Any investigation of local identifiability must either yield a mapping of identifiability onto the entire parameter space, which will rarely be feasible in any applications of interest, or confine itself to the neighbourhood of such points of special interest as the maximum likelihood point.The author would like to thank J. Jack McArdle and Colin Fraser for their comments on this paper.  相似文献   
15.
Nineteen agoraphobic outpatients were randomly assigned to four sessions of either (1) Exposure: planning and discussion of exposure homework tasks requiring patients to enter and remain in phobic situations hitherto avoided; or (2) Control: discussion of marital, family and social difficulties and strategies for dealing with these.A small but significant effect was found at post-test and at one month follow-up in favour of the exposure condition. It is suggested that this variable should be controlled in future relevant experiments and is worth including as an inexpensive expedient of active treatment of phobias.  相似文献   
16.
After being exposed to either an aggressive or a nonaggressive filmed model, four- and five-year-old boys were tested for imitation while either alone or with a confederate who had also seen the film. The confederate's behavior was either inactive, the same as that in the film, the same as that in the film the child had not seen, novel but of the same category (aggressive or nonaggressive) as that in the film seen, or novel but in the category of the film not seen. These conditions conformed to the dimensions of a 2 × 6 factoral design. According to prediction, the imitation of subjects exposed to the aggressive model was greatest when the confederate's behavior was similar to the model's. No difference in imitation was produced by the confederate's actions if the boy had watched the nonaggressive model. The results were interpreted within the context of social comparison theory.This project was facilitated by the senior author's Margaret Bosshardt Pace and Paul David Pace Research Fellowship.  相似文献   
17.
Accessibility of characters in two-character sentences (e.g., The butler helped Calvin at the wedding reception) was investigated with a probe recognition task. Probes were either the first character (e.g., butler) or the second character (e.g., Calvin) in a sentence and were designated by proper names or common nouns crossed with name or noun nonprobes. Results show that (1) probes in first position are more accessible than those in second position, but not when noun probes are paired with name nonprobes, (2) characters designated by names are generally more accessible than those designated by nouns, and (3) the first name in a sentence is more available than other characters, regardless of position. Thus, accessibility of characters in a sentence seems dependent on discourse function, with named characters seen as main characters, rather than on nondiscourse-related factors, such as temporal distinctiveness.  相似文献   
18.
Almost all research on aggression in adolescent romantic relationships makes use of 1-time, retrospective assessment methods. In the present research, the authors compared data on the experience of adolescent relationship aggression (physical aggression and threatening behavior) collected from 125 high school students via 2 methods: (a) a 1-time, 2-month retrospective assessment and (b) a cumulative method based on four 2-week retrospective assessments, each spaced 2 weeks apart. For the cumulative method, data from the 4 assessments were aggregated to cover the same time period as the single, 2-month retrospective assessment. A greater proportion of the sample (48.0%) reported experiencing physical aggression using the cumulative method compared with the single, 2-month retrospective method (27.0%). The prevalence of threatening behavior was also higher using the cumulative method (48.8% vs. 24.8%). Adolescent trauma and anxiety symptoms correlated more strongly with physical aggression data derived from the cumulative method than from the 1-time assessment method.  相似文献   
19.
Deficits in pragmatic language ability are common to a number of clinical populations, for example, right-hemisphere damage (RHD), Autism and traumatic brain injury (TBI). In these individuals the basic structural components of language may be intact, but the ability to use language to engage socially is impaired. Despite the nature of these difficulties being well documented, exactly what causes these difficulties is less clear. Furthermore, the current status of causal explanations for pragmatic difficulties across these populations is divergent and sometimes contradictory. This paper explores the empirical validity of three theories that attempt to explain pragmatic language impairment. It is recommended that a new, more convergent approach to investigating the causes of pragmatic language disability be adopted.  相似文献   
20.
It is thought that circadian rhythms may influence learning and memory processes. However, research supporting this view does not dissociate a mnemonic impairment from other performance deficits. Furthermore, published reports do not specify the type of memory system influenced by the circadian system. The present study assessed the effects of phase shifting on acquisition and expression of place navigation in the water maze, a task sensitive to hippocampal dysfunction. The results showed that phase-shifting circadian rhythms in rats impaired the expression of place information on a retention test but not initial acquisition or encoding of place information. These results suggest that disruption of circadian rhythms may impair consolidation of previously encoded hippocampal place information.  相似文献   
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