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41.
New methodologies to assess analgesic response in humans are needed to better integrate preclinical and clinical data. In the present study we examined the test-retest stability of an innovative radiant heat methodology compared with an electrical stimulation methodology. For the radiant heat task, a modified rodent tail flick apparatus was used. The latency for finger withdrawal was recorded. For the electrical stimulation tasks, subjects placed two fingers on two electrodes from which they received a brief series of increasingly intense electrical stimulations. Maximum stimulus intensity (in milliamps) delivered was recorded. On each of 4 test days, the subjects received five test trials with a 10-min interval between trials. All the subjects were tested twice on each apparatus in a counterbalanced design. Finger withdrawal latencies for the radiant heat task did not differ significantly across test trials or test days. Finger withdrawal scores for electrical stimulation increased significantly across test trials as well as test days. These data show that the radiant heat method generates consistent latencies across trials and days, whereas shock produces trends over time. The radiant heat task, which is convenient to operate and inexpensive to build, appears promising as a reliable test of pain threshold in humans.  相似文献   
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Child's Play: A Multidisciplinary Perspective   总被引:1,自引:0,他引:1  
Competition obscures the realities and significance of play, in particular, the bodily play originating in infancy and typical of young children. A multidisciplinary perspective on child's play elucidates the nature of child's play and validates the distinction between competition and play. The article begins with a consideration of ethological research on play in young human and nonhuman animals, proceeds to a consideration of psychological research on laughter as a primary kinetic marker of play, and ends with a philosophical examination of the foundational moral significances of child's play. This revised version was published online in July 2006 with corrections to the Cover Date.  相似文献   
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Death and immortality ideologies in Western philosophy   总被引:1,自引:0,他引:1  
This article examines immortality ideologies in Western philosophy as exemplified in the writings of Descartes, Heidegger, and Derrida, showing in each instance the distinctiveness of the ideology. The distinctiveness is doubly significant: it broadens understandings of the nature of immortality ideologies generally and deepens comparative understandings of the ideologies of the philosophers discussed. Pertinent writings of Otto Rank, the psychiatrist who first wrote of immortality ideologies, contribute in fundamental ways to the discussion as do pertinent writings of cultural anthropologist Ernest Becker, who elaborated and publicized Rank's thesis concerning immortality ideologies. The notion of an ideology, clarified in the beginning as an empirically unfounded belief structure, hence an illusion, is taken up briefly but pointedly at the end in the context of Rank's distinction between rational and irrational elements of the self as they are played out in the creations of the hero-artist. The article ends by examining his distinction in the context of the philosophic perspectives discussed, most notably the perspective of Heidegger.  相似文献   
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In a cultural climate of “intensive parenting” and concerns about the “obesity epidemic,” parents are expected to take responsibility for their children's health, particularly through the provision of a “healthy” diet. This study involved intergenerational dyad interviews with both middle‐class and working‐class mothers and daughters from the United Kingdom. Analysing the data using discourse analysis informed by feminist poststructuralist theory, we found that mothers were positioned as having prime responsibility for the nurturing of family members, including the provision of a healthy diet. However, providing a healthy diet alone was insufficient; mothers needed to demonstrate that time and effort had been taken in the preparation of meals using fresh ingredients. Those who failed to do so were positioned as “lazy,” thus inviting the blaming of mothers for any current or future health problems encountered by family members (especially children). However, talk from some of the working‐class mothers pointed to the unattainable and “classed” ideals that are set by such cultural expectations.  相似文献   
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The aim of this study was to validate a computer-assisted screening battery for classifying patients into two groups, those with and without cognitive impairment. Participants were all patients referred to the neuropsychology clinics at four VA medical centers during a 1-year period. Patients meeting the study inclusionary criteria (N = 252) were administered the Neurobehavioral Evaluation System-3 (NES3) computer-assisted battery. A detailed neuropsychological examination was carried out by an experienced neuropsychologist, who diagnosed the patient as cognitively impaired or not impaired. The neuropsychologist's diagnosis was the gold standard. Recursive partitioning analyses yielded several classification procedures using the NES3 data to predict the gold standard These procedures produced a set of six NES3 tasks that provide good sensitivity and specificity in predicting di- agnosis. Sensitivity and specificity for the least random classification procedure were 0.87 and 0.67, respectively. The results suggest that computer-assisted screening methods are a promising means of triaging patients.  相似文献   
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