Drug Tolerance, Drug Addiction, and Drug Anticipation

ABSTRACT— Environmental cues associated with drugs often elicit withdrawal symptoms and relapse to drug use. Such cues also modulate drug tolerance. The contribution of drug-associated stimuli to withdrawal and tolerance is emphasized in a Pavlovian-conditioning analysis of drug administration. Conditional responses occur in the presence of cues that have been associated with the drug in the past, such as the setting in which the drug was taken. These conditional responses mediate the expression of tolerance and withdrawal symptoms. Recently, it has become apparent that internal predrug cues, as well as environmental cues, elicit pharmacological conditional responses that contribute to tolerance and withdrawal. Such internal cues include cognitive or proprioceptive cues incidental to self-administration, drug-onset cues that are experienced shortly after administration, and emotional cues. According to the conditioning analysis, addiction treatment should incorporate learning principles to extinguish the association between stimuli (environmental and internal) present at the time of drug administration and the effects of the addictive drug.     

Photographs of facial expression: accuracy, response times, and ratings of intensity.

Equal numbers of male and female participants judged which of seven facial expressions (anger, disgust, fear, happiness, neutrality, sadness, and surprise) were displayed by a set of 336 faces, and we measured both accuracy and response times. In addition, the participants rated how well the expression was displayed (i.e., the intensity of the expression). These three measures are reported for each face. Sex of the rater did not interact with any of the three measures. However, analyses revealed that some expressions were recognized more accurately in female than in male faces. The full set of these norms may be downloaded from www.psychonomic.org/archive/.     

Parallel processing of whole words and morphemes in visual word recognition

Models of morphological processing make different predictions about whether morphologically complex written words are initially decomposed and recognized on the basis of their morphemic subunits or whether they can directly be accessed as whole words and at what point semantics begin to influence morphological processing. In this study, we used unprimed and masked primed lexical decision to compare truly suffixed (darkest) and pseudosuffixed words (glossary) with within-boundary (d ra kest/g ol ssary) to across-boundary (dar ek st/glos as ry) letter transpositions. Significant transposed-letter similarity effects were found independently of the morphological position of the letter transposition, demonstrating that, in English, morphologically complex whole-word representations can be directly accessed at initial word processing stages. In a third masked primed lexical decision experiment, the same materials were used in the context of stem target priming, and it was found that truly suffixed primes facilitate the recognition of their stem-target (darkest-DARK) to the same extent as pseudosuffixed primes (glossary-GLOSS), which is consistent with theories of early morpho-orthographic decomposition. Taken together, our findings provide evidence for both whole-word access and morphological decomposition at initial stages of visual word recognition and are discussed in the context of a hybrid account.     

Very brief exposure II: the effects of unreportable stimuli on reducing phobic behavior

This experiment compared the effects of exposure to masked phobic stimuli at a very brief stimulus-onset asynchrony on spider-phobic and non-phobic individuals. Participants were identified through a widely used questionnaire and a Behavioral Avoidance Test (BAT) with a live, caged tarantula to establish baseline levels of avoidance. One week later, they were individually administered one of two continuous series of masked images: spiders or flowers. Preliminary masking experiments showed that independent samples of participants from the same populations failed to recognize these stimuli. Participants in the main experiment reported ratings of subjective distress immediately before and after the exposure manipulation. Then they engaged in the BAT once again. Very brief exposure to images of spiders reduced phobic participants' avoidance of the tarantula. No effects were evidenced on subjective distress, or on non-phobic participants. Theoretical implications for the non-conscious basis of fear are discussed.     

Dying for romance: risk taking as purposive behavior

Many approaches have been utilized to understand adolescent risk taking. The current research frames risk taking as a purposive behavior enacted with a specific goal in mind. Rather than assuming adolescent risk taking to be the result of arrogance or perceived invulnerability, adolescent risk taking is interpreted as a means to an end. Stemming from a Tolmanian framework, an alternative explanation for adolescent risk taking is tested: adolescents are willing to take risks to the extent that the risk is associated with a needed outcome - the greater the need for the outcome, the greater the willingness to take risks. To test the proposed hypothesis, 192 participants completed a survey about their need for a romantic relationship and their willingness to endure harm to obtain a romantic relationship. Data were collected at two time points. A hierarchical regression revealed that need for romance is a significant predictor of willingness to endure harm for romance, even after gender and sensation seeking are statistically controlled. Moreover, need for romance at T1 was shown to be predictive of harm for romance at T2. Results are supportive of taking a purposive - that is, Tolmanian - approach, as a means for interpreting adolescent behavior.     

Gender moderates the relationship between emotion and perceived gaze

Recent evidence shows that gender modulates the morphology of facial expressions and might thus alter the meaning of those expressions. Consequently, we hypothesized that gender would moderate the relationship between facial expressions and the perception of direct gaze. In Study 1, participants viewed male and female faces exhibiting joy, anger, fear, and neutral expressions displayed with direct and averted gazes. Perceptions of direct gaze were most likely for male faces expressing anger or joy and for female faces expressing joy. Study 2 established that these results were due to facial morphology and not to gender stereotypes. Thus, the morphology of male and female faces amplifies or constrains emotional signals and accordingly alters gaze perception.     

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