GOOD or BAD responder? Behavioural and neuroanatomical markers of clinical response to donepezil in dementia

We explored the neuropsychological and neuromorphometrical differences between probable Alzheimer's disease patients showing a good or a bad response to nine months treatment with donepezil. Before treatment, the neuropsychological profile of the two patient groups was perfectly matched. By the ninth month after treatment, the BAD-responders showed a decline of the MMSE score together with a progressive impairment of executive functions. A voxel-based morphometry investigation (VBM), at the time of the second neuropsychological assessment, showed that the BAD-responders had larger grey and white matter atrophies involving the substantia innominata of Meynert bilaterally, the ventral part of caudate nuclei and the left uncinate fasciculus, brain areas belonging to the cholinergic pathways. A more widespread degeneration of the central cholinergic pathways may explain the lack of donepezil efficacy in those patients not responding to a treatment that operates on the grounds that some degree of endogeneous release of acetylcholine is still available.     

Transdiagnostic assessment of temporal experience (TATE) a tool for assessing abnormal time experiences

Phenomenology and the Cognitive Sciences - Currently, anomalous lived temporality is not included in the main diagnostic criteria or standard symptom checklists. In this article, we present the...     

Factor Validity of the Beck Hopelessness Scale in Italian Medical Patients

The aim of the present study was to assess the factor structure of the Italian version of the Beck Hopelessness Scale (BHS) in a large sample of patients with medical conditions, comparing four different models proposed previously in the literature. Participants were 514 Italian adult patients with diagnoses of chronic daily headache, type 1 (insulin-dependent) or type 2 diabetes mellitus, epilepsy, open-angle glaucoma, human immunodeficiency virus infection, and women admitted for childbirth to a Department of Fetal–Maternal Medicine. All the patients were administered the BHS during routine visits. Confirmatory factor analyses were used to compare four models using several fit indices. The one-construct two-method model (i.e., the BHS measures one substantive hopelessness construct plus artifacts due to negative–positive item polarity) had the best fit indices and was more parsimonious than other models. The BHS seems to be a unidimensional measure of hopelessness, although there may be artifacts due to item polarity (i.e., positively and negatively worded items). Hopelessness scores differed in patients with particular medical diseases, with higher scores in conditions such as chronic daily headache and diabetes, and lower scores in patients positive for the human immunodeficiency virus (HIV), and with open-angle glaucoma or epilepsy.     

Immigration in Italy: Between Economic Acceptance and Political Rejection

Italy, especially in its richer regions and cities, is experiencing a profound contradiction in its relationship with the immigrant component of its population: it is becoming even more multi-ethnic in terms of the number of residents (5.3 million), participation in the labor market (more than 3 million), transitions to self-employment (213,000 business owners), and immigrant students in schools (about 670,000). In their cultural representations, Italians tend to deny this reality. They do not want multi-ethnic cities. Faced with the widespread use of a workforce of regular and irregular immigrants, in families and enterprises of the urban economy, the prevailing opinion rejects the idea of giving a place to immigration in the nation’s social organization, and this position is strengthened by political forces and media that reflect and exacerbate the reaction. Immigrants seem to be accepted, perhaps, on an individual plane, where they have a name and a definite place in society—helpful, modest, possibly invisible. They are frightening when they become visible communities, when they settle in urban settings, when they look for places and opportunities for socialization. Italian society, as a result of tensions between markets, politics, and culture on the issue of immigration, is facing a dilemma: how to reconcile interests and feelings, head and heart, individuals and communities: how to rebuild sufficient social cohesion in a society that is increasingly differentiated and heterogeneous.     

Teacher-initiated Motivational Climate in Physical Education Questionnaire in an Italian sample

The purpose of the study was to translate and adapt in the Italian language a questionnaire that could effectively assess perceived motivational climate in physical education. An Italian version of the Teacher-initiated Motivational Climate in Physical Education Questionnaire proposed by Papaioannou (1998) was administered to 1,681 young students, 840 girls and 841 boys, ages 11 to 14 years. Data were subjected to confirmatory factor analysis to assess the goodness of fit of the expected two-factor solution constituted by a Mastery Climate scale (six items) and a Performance Climate scale (six items). A good fit was indicated between the observed data and theoretical model and supported the two-dimensional structure of the test. In the total sample, the Mastery factor accounted for 33.6% of the variance and the Performance factor accounted for 15.4%. Cronbach alpha of the Mastery and Performance scales were .79 and .70, respectively.     

Cannabis use and the risk behavior syndrome in Italian university students: are they related to suicide risk?

The aim of this study was to examine the association of cannabis use with risky behaviors and suicide risk in university students. A convenience sample of 246 students was recruited from four universities in Rome during the 2004 academic year. Participants completed the Zung scales for anxiety and depression, the Suicide Score Scale, and an ad hoc questionnaire assessing risky behaviors. The findings indicated a widespread use of cannabis among students and its association with risky behaviors, anxiety and depression, and suicide risk. A regression tree analysis resulted in 3 splits indicating that the Zung Self-Rating Depression Scale is a good predictor of suicide risk, discriminating individuals at lower risk from those at higher risk. Individuals at higher risk for suicide could also be discriminated by self-reported lifetime drug use. Limitations of the study are related to the small sample size and use of a convenience sample.     

Time estimation in Alzheimer's disease and the role of the central executive

The aim of this study was to evaluate the role of short-term memory and attention in time estimation. For this purpose we studied prospective time verbal estimation in 21 patients with Alzheimer's disease (AD), and compared their performance with that of 21 matched normal controls in two different conditions: during a digit span task and during an attentional task. Results showed that the performance of AD patients was significantly worse than that of the controls; the interaction between group and condition was significant. We suggest a role of attentional-executive functions in prospective time estimation.     

Shaping Individuality: Human Inheritable Germ Line Gene Modification

In this paper I deal with ethical factors surrounding germline gene therapy. Such implications include intergenerational responsibility, human dignity, moral status of embryos and so on. I will explore the relevance of the above mentioned issues to discuss the ethical implication of human germline gene therapy (HGLT). We will see that most of arguments claimed by bioethicists do not provide valid reason to oppose HGLT. I will propose an alternative view, based on personal identity issues, to discuss the ethics of human inheritable gene modification. This revised version was published online in August 2006 with corrections to the Cover Date.     

Between Fears,Contacts and Family Dynamics: the Anti-Immigrant Attitudes in Italy

Empirical research on sources of prejudice and anti-immigrant hostility has grown considerably over the years, and the literature on the topic has become substantial firstly in classical receiving countries and in recent years also in Europe. This work analyses the anti-immigrant attitudes in Italy. The main results of this study are three. The first is the importance of individual characteristics in explaining anti-immigrant hostility: much of the variability in anti-immigrant hostility is due to individual characteristics, and in particular to the educational level achieved. Second, contacts have opposite effect on hostility: real contacts (i.e., real interpersonal contacts) decrease anti-immigrant hostility, while abstract contacts (i.e., contacts mediated by mass media) increase hostility towards migrants. Third, anti-immigrant hostility is lower among issues concerning family immigration dynamics.